2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Levobetaxolol

Levobetaxolol  (Synonyms: (S)-Betaxolol)

目录号: HY-121166
产品使用指南

摩尔计算器

Levobetaxolol 是一种有效且高亲和力的 β-adrenergic 拮抗剂，对豚鼠心房 β1、气管β2 和大鼠结肠 β3 受体的 IC50 值分别为 33.2, 2970, 709 nM。Levobetaxolol 可降低 IOP（眼内压）。Levobetaxolol 对 L 型 Ca21 通道具有微摩尔亲和力。Levobetaxolol 可降低大鼠缺血/再灌注损伤的影响。Levobetaxolol 具有青光眼研究潜力。

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Levobetaxolol Chemical Structure

Levobetaxolol Chemical Structure

CAS No. : 93221-48-8

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Levobetaxolol 的其他形式现货产品:

Customer Review

Other Forms of Levobetaxolol:

Levobetaxolol 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Levobetaxolol is a potent and high affinity β-adrenergic antagonist with IC50 values of 33.2, 2970, 709 nM for guinea pig atrial β1, tracheal β2 and rat colonic β3 receptors, respectively. Levobetaxolol reduces IOP (intraocular pressure). Levobetaxolol exhibits a micromolar affinity for L-type Ca21-channels. Levobetaxolol decreases the effects of ischaemia/reperfusion injury in rats. Levobetaxolol has the potential for the research of glaucoma[1][2].

IC50 & Target[1]

β1 adrenoceptor

33.2 nM (IC50)

β2 adrenoceptor

2970 nM (IC50)

β3 adrenoceptor

709 nM (IC50)

体外研究
(In Vitro)

Levobetaxolol shows a higher affinity at cloned human β1 and β2 receptor with Ki values of 0.76, 32.6 nM, respectively[1].
Levobetaxolol inhibits functional activities in cells expressing human recombinant β1 and β2 receptors with Kb values of 6, 39 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Levobetaxolol 相关抗体:
Clinical Trial
分子量

307.43

Formula

C18H29NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Levobetaxolol 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levobetaxolol93221-48-8(S)-BetaxololAdrenergic ReceptorBeta ReceptorIOPL-type Ca21-channelshigher affinityglaucomaInhibitorinhibitorinhibit

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