2. Neuronal Signaling Apoptosis
  3. Amyloid-β Apoptosis
  4. β-Amyloid (1-40) (rat)

β-Amyloid (1-40) (rat)  (Synonyms: β淀粉样肽(1-40)(鼠))

目录号: HY-P1387 纯度: 95.13%
COA 产品使用指南

摩尔计算器

β-Amyloid (1-40) (rat) 是一种大鼠形式的淀粉样 β-肽，它作为不溶性细胞外沉积物积聚在神经元周围，引起与阿尔茨海默病 (AD) 相关的老年斑。β-Amyloid (1-40) (rat) 增加 45Ca2+ 内流，诱导大鼠海马 CA1 亚区神经元变性。β-Amyloid (1-40) (rat) 诱导细胞凋亡 (apoptosis)。 β-Amyloid (1-40) (rat) 可以用于阿尔茨海默病的研究。

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Custom Peptide Synthesis

β-Amyloid (1-40) (rat) Chemical Structure

β-Amyloid (1-40) (rat) Chemical Structure

CAS No. : 144409-98-3

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2200
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Customer Review

β-Amyloid (1-40) (rat) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45Ca2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease[1][2].

体外研究
(In Vitro)

β-Amyloid (1-40) (rat) (1 μM; 1 h) increases 45Ca2+ influx and elevates Ca2+ in cortical synaptosomes[1].
β-Amyloid (1-40) (rat) (3 nM) induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield and induces apoptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Amyloid (1-40) (rat) 相关抗体:
体内研究
(In Vivo)

β-Amyloid (1-40) (rat) (1.7 mg; ICV, for 7 d; swiss and C57BL/6 mice) induces the learning and memory deficits in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss and C57BL/6 mice[3]
Dosage: 1.7 mg
Administration: Intracerebroventrical injection; for 7 days
Result: Presented spatial learning and memory impairments.
分子量

4233.76

Formula

C190H291N51O57S
CAS 号
性状

固体

颜色

White to off-white

Sequence

Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
Sequence Shortening

DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV
中文名称

β淀粉样肽(1-40)(鼠)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

β-Amyloid (1-40) (rat) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Amyloid (1-40) (rat)144409-98-3β淀粉样肽(1-40)(鼠)Amyloid-βApoptosisβ-amyloid peptideAβAbetaAlzheimer's diseaseapoptosisCa2+hippocampal neuronsInhibitorinhibitorinhibit

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