2. GPCR/G Protein
  3. CRFR
  4. Urocortin II, mouse

Urocortin II, mouse 是一种选择性的 2 型促肾上腺皮质激素释放因子 (CRF2) 受体内源性多肽激动剂，对 CRFR2 和 CRFR1 的 Ki 值分别为 0.66 nM 和 ﹥100 nM。Urocortin II, mouse 通过以 cAMP/PKA 和 Ca2+/CaMKII 依赖性方式激活 CRF2 受体。Urocortin II, mouse 在中枢神经系统的离散区域表达，并激活参与内脏感觉信息处理和调节自主神经外流的中枢神经元。

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Custom Peptide Synthesis

Urocortin II, mouse Chemical Structure

Urocortin II, mouse Chemical Structure

CAS No. : 330648-32-3

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Urocortin II, mouse 相关抗体

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CRFR1 CRFR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow[1][2][3].

IC50 & Target[2]

CRFR2

0.66 nM (Ki)

CRFR1

﹥100 nM (Ki)

体外研究
(In Vitro)

Urocortin II, mouse 通过激活 CRF2 受体在小鼠心室肌细胞中引起正性肌力和正性变性作用[1]。
Urocortin II, mouse 通过以 cAMP/PKA 和 Ca2+/CaMKII 依赖性方式激活 CRF2 受体[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Urocortin II, mouse 相关抗体:
体内研究
(In Vivo)

Urocortin II, mouse (1-10 μg; icv and i.v.; 成年雄性 SD 大鼠) 诱导 Fos 的表达[2]。
Urocortin II, mouse (1 μg; icv; 成年雄性 SD 大鼠) 参与中枢自主神经系统和食欲控制[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (250-300 g)[2]
Dosage: 1, 5, and 10 μg
Administration: Intracerebroventrical injection and intravenous injection; 1, 5, or 10 μg per animal in 2 μL of saline for i.c.v. injections or 200 μL for i.v. administration
Result: Induced Fos expression in a dose-dependent manner.
Animal Model: Adult male Sprague-Dawley rats (250-300 g)[2]
Dosage: 1 μg
Administration: Intracerebroventrical injection
Result: Reduced food intake over the 12-h interval.
分子量

4152.96

Formula

C187H320N56O50
CAS 号
Sequence

Val-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val-NH2
Sequence Shortening

VILSLDVPIGLLRILLEQARYKAARNQAATNAQILAHV-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Urocortin II, mouse 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Urocortin II, mouse330648-32-3CRFRCorticotropin-releasing Factor ReceptorCRHRendogenous peptidemouse ventricular myocytescentral nervous systemdiscrete areavisceral sensory informationInhibitorinhibitorinhibit

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