2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. BBMP

BBMP  (Synonyms: 5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone)

目录号: HY-108984
产品使用指南

摩尔计算器

BBMP 是一种通透性转换孔 (PTP) 抑制剂。BBMP 可防止 Ca2+ 诱导的通透性转换和线粒体去极化。BBMP 具有神经退行性疾病研究的潜力。

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BBMP Chemical Structure

BBMP Chemical Structure

CAS No. : 97120-13-3

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BBMP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca2+-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research[1].

体外研究
(In Vitro)

BBMP 在肿胀和膜电位测定中均有效，pIC50 值分别为 5.5 和 5.6。BBMP 剂量依赖性地防止小脑颗粒神经元中 KCl 25/5 mM 转移和血清剥夺引起的 DNA 碎片化，pIC50 为 5.7。在 10 和 100 μM 时观察到的分离线粒体中 PTP 介导的细胞色素 c 释放的抑制可能解释了其体外神经保护特性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BBMP 相关抗体:
分子量

343.20

Formula

C12H11BrN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BBMP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BBMP97120-13-35-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinoneMitochondrial Metabolismpermeability transition pore inhibitormitochondrial depolarizationeurodegenerative disordersInhibitorinhibitorinhibit

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