2. Metabolic Enzyme/Protease Apoptosis
  3. Carbonic Anhydrase Apoptosis
  4. hCAIX/XII-IN-5

hCAIX/XII-IN-5 (Coumarin 9a) 是一种碳酸酐酶 (CA) 抑制剂，并表现出比对 hCA I 和 hCA II 极佳的 hCA IX/XII 选择性 (Ki 分别为 93.9 和 85.7 nM)。hCAIX/XII-IN-5 对癌细胞显示出抗增殖活性。hCAIX/XII-IN-5 能延迟细胞周期并诱导细胞的凋亡。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

hCAIX/XII-IN-5 Chemical Structure

hCAIX/XII-IN-5 Chemical Structure

CAS No. : 2421127-99-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

hCAIX/XII-IN-5 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (Ki=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis[1].

IC50 & Target

hCA XII

85.7 nM (Ki)

hCA IX

93.9 nM (Ki)

体外研究
(In Vitro)

hCAIX/XII-IN-5 (2.36-32.17 μM) treatment shows both anti-proliferative activities to MCF-7 and PANC-1 cells under the normoxic and hypoxic condition[1].
hCAIX/XII-IN-5 (2.69 μM; 24 h) treatment shows accumulation of MCF-7 cells in the Sub-G1 phase and cell arrest in G2-M phase[1].
hCAIX/XII-IN-5 (2.69 μM; 24 h) treatment increases the percent of annexin V-FITC-positive apoptotic cells, including both the early and late apoptotic cells (UR+LR) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCAIX/XII-IN-5 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7 and PANC-1 cells
Concentration: 2.36-32.17 μM
Incubation Time:
Result: Exerted anti-proliferative activities to MCF-7 and PANC-1 cells (IC50=2.69 μM and 32.17 μM, respectively) under the normoxic condition, and moderate activitits against both MCF-7 and PANC-1 cells (IC50=16.36 μM and 11.78 μM, respectively) under the hypoxic condition.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2.69 μM
Incubation Time: 24 hours
Result: Resulted in a significant increase in the percentage of cells at Sub-G1 by 14-folds with significant increase in cell percentage in the G1-M phase by 2.3-folds compared to the control.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2.69 μM
Incubation Time: 24 hours
Result: Resulted in a significant increase in the percent of annexin V-FITC-positive apoptotic cells, including both the early (from 0.61% to 6.77%) and late apoptotic (from 0.27% to 14.84%) cells (UR+LR), about 11- and 55-fold increase, respectively, as compared with the control.
分子量

291.30

Formula

C18H13NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCAIX/XII-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX/XII-IN-52421127-99-1Carbonic AnhydraseApoptosisCarbonate dehydrataseanti-proliferative activityMCF-7PANC-1delay cell cycleapoptosisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
hCAIX/XII-IN-5
目录号：
HY-150695
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z