Absinthin  (Synonyms: 洋艾素)

Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46^[1][2][3].

Absinthin (10 μM, 60 s)通过 hTAS2R46 抑制气道平滑肌 (ASM) 细胞中组胺诱导的 Ca²⁺ 增加^[3]。
Absinthin (1 和 10 μM，1 h 或 18 h) 显示抗氧化活性，并抑制 BEAS-2B 细胞中 PMA (HY-18739) 诱导的超氧阴离子产生(1 小时)和 iNOS 表达 (18 小时)^{[5 ]}。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Absinthin (20-80mg/kg, 口服) 可缓解 LPS 引起的急性肺损伤 (减少炎症细胞浸润并改善 小鼠的肺结构)^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

496.64

C₃₀H₄₀O₆

1362-42-1

固体

White to off-white

洋艾素

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Zhang W, et al. Total synthesis of absinthin. J Am Chem Soc. 2005 Jan 12;127(1):18-9.  [Content Brief]

  [2]. Lachenmeier DW, et al. Absinthe--a review. Crit Rev Food Sci Nutr. 2006;46(5):365-77.  [Content Brief]

  [3]. Talmon M, et al. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event. J Biol Chem. 2019 Aug 16;294(33):12472-12482.  [Content Brief]

  [4]. Guo N, et al. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration. Exp Lung Res. 2015;41(9):514-24.  [Content Brief]

  [5]. Talmon M, et al. Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells. J Nat Prod. 2020 Jun 26;83(6):1740-1750.  [Content Brief]