2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Calcium Channel Reactive Oxygen Species Apoptosis
  4. Dantrolene

Dantrolene  (Synonyms: 丹曲洛林; F 368)

目录号: HY-12542 纯度: ≥98.0%
COA 产品使用指南 技术支持

Dantrolene 是一种具有口服活性的、非竞争性谷胱甘肽还原酶抑制剂，Ki 为 111.6 μM，IC50 为 52.3 μM。Dantrolene 也是一种钙通道蛋白抑制剂。Dantrolene 抑制 RyR1 和 RyR3 释放 Ca2+，对钙稳态破坏引起的各种病理 (如中风、缺血/再灌注损伤和神经退行性疾病) 有益。Dantrolene 还具有缓解肌肉痉挛、恶性高热和解毒、镇痛、抗炎功效。

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Dantrolene Chemical Structure

Dantrolene Chemical Structure

CAS No. : 7261-97-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥449
In-stock
1 mg ￥260
In-stock
5 mg ￥650
In-stock
10 mg ￥920
In-stock
25 mg ￥1300
In-stock
50 mg ￥1880
In-stock
100 mg ￥2500
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Dantrolene:

Dantrolene 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties[1][2][3][4][5][6][7][8][9][10][11].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.059 μM
Compound: Dantrolene
Inhibition of RyR1 harboring R2163C mutant (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as suppression in Ca2+ leakage from ER prestimulated with doxycycline for 24 to 28 hrs followed by compound addition at 100 secs
Inhibition of RyR1 harboring R2163C mutant (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as suppression in Ca2+ leakage from ER prestimulated with doxycycline for 24 to 28 hrs followed by compound addition at 100 secs
[PMID: 31299492]
体外研究
(In Vitro)

Dantrolene (50 μM) sodium 通过增加大鼠皮肤纤维中 ryanodine 受体 (RyR) 对 Mg2+ 的亲和力阻止过度活跃的 Ca2+ 释放，从而缓解恶性高热症[2]。
Dantrolene (30 μM, 1 h-3 days) sodium可改善阿尔茨海默病患者来源诱导多能干细胞的神经发生和突触生成障碍，同时恢复细胞内 2+ 稳态和生理性自噬、细胞存活和增殖[3]。
Dantrolene (40 μM, 12 h) sodium 可增强低温对大脑皮层神经元的保护作用，包括改善形态、提高存活率和线粒体膜电位、减少细胞内活性氧、细胞质组蛋白相关 DNA 断裂和细胞凋亡[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dantrolene 相关抗体:

Cell Differentiation Assay[3]

Cell Line: Induced pluripotent stem cells from patients with familiar and sporadic Alzheimer’s disease
Concentration: 30 μM
Incubation Time: 3 days
Result: Promoted differentiation of neuroprogenitor cell derived from sporadic Alzheimer’s disease/familial Alzheimer’s disease induced pluripotent stem cells into immature neurons at differentiation day 23.
Promoted the percentage of Trb1 positive cells.
Promoted differentiation into basal forebrain cholinergic neurons.
体内研究
(In Vivo)

Dantrolene (5-20 mg/kg, i.v.) sodium在 Digoxin (HY-B1049) 引起的心脏毒性大鼠模型中具有心脏保护作用[4]。
Dantrolene (5-10 mg/kg, i.p.) sodium减轻实验性自身免疫性脑脊髓炎 (EAE) 小鼠的脊髓炎症[5]。
Dantrolene (5 mg/kg, 鼻腔内或皮下, 每周 3 次) sodium可以改善 5XFAD 阿尔兹海默症小鼠认知功能障碍[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 male mice (EAE was induced by subcutaneous administration of a total of 300 μg in the flanks (each flank received 150 μg) of rodent myelin oligodendrocyte glycoprotein peptide 35–55 (MEVGWYRSPFSRVVHLYRNGK, New England Peptide) emulsified in the complete Freund’s adjuvant containing Mycobacterium tuberculosis H37Ra[5]
Dosage: 5, 10 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Reduced the severity of EAE clinical symptoms and dampened inflammation in the spinal cord
Caused skeletal muscle weakness at 5 mg/kg.
Did not display noticeable upright movement deficits on flat-surface at 5 mg/kg.
Clinical Trial
分子量

314.26

Formula

C14H10N4O5
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

丹曲洛林；丹曲林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 16.67 mg/mL (53.05 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1821 mL 15.9105 mL 31.8211 mL
5 mM 0.6364 mL 3.1821 mL 6.3642 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    Dantrolene is suspended in 50 μL of PBS with 2% corn flour[5].

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (286 KB) HNMR (131 KB)

产品使用指南 (1538 KB)
参考文献

Dantrolene 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1821 mL 15.9105 mL 31.8211 mL 79.5527 mL
5 mM 0.6364 mL 3.1821 mL 6.3642 mL 15.9105 mL
10 mM 0.3182 mL 1.5911 mL 3.1821 mL 7.9553 mL
15 mM 0.2121 mL 1.0607 mL 2.1214 mL 5.3035 mL
20 mM 0.1591 mL 0.7955 mL 1.5911 mL 3.9776 mL
25 mM 0.1273 mL 0.6364 mL 1.2728 mL 3.1821 mL
30 mM 0.1061 mL 0.5304 mL 1.0607 mL 2.6518 mL
40 mM 0.0796 mL 0.3978 mL 0.7955 mL 1.9888 mL
50 mM 0.0636 mL 0.3182 mL 0.6364 mL 1.5911 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dantrolene7261-97-4F 368丹曲洛林丹曲林F368F-368Calcium ChannelReactive Oxygen SpeciesApoptosisCa2+ channelsCa channelsorallynon-competitiveglutathione reductaseryanodine receptorRyRCa2+muscle spasticitymalignant hyperthermiaHuntington's diseaseneuroleptic malignant syndromeInhibitorinhibitorinhibit

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