2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 根据产品特点分类
  6. 线粒体毒性化合物库
线粒体毒性化合物库 - Mitochondrial Toxicity Compound Library

Cat. No.: HY-L155

线粒体作为生命体提供能量的主要场所，对维持正常的生命活动是至关重要的。线粒体功能障碍与常见疾病息息相关，如心血管疾病、神经退行性疾病、糖尿病和癌症。心脏、大脑和肝脏严重依赖线粒体功能从而作为药物代谢的主要器官。此外，线粒体也是许多药物的靶点，一些药物通过诱导线粒体毒性从而引发器官毒性。

MCE 收录了 486 种线粒体毒性化合物，可作为新药研发以及疾病机制研究的工具化合物。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 线粒体毒性化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，476 个产品以 10 mM 浓度提供，9 个产品以 2 mM 浓度提供，1 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 486 mitochondrial toxicity compounds for high throughput screening (HTS) and high content screening (HCS).

•   Including autophagy, apoptosis, cell cycle, DNA damge and DNA/RNA synthesis-regulating agent, etc.

•   Including antibiotics, anti-cancer drugs, cardiac medications and anti-inflammatory agent, etc.

•   Structurally diverse, bioactive and cell permeable.

•   More detailed compound information with structure, IC50 and brief introduction.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 486 mitochondrial toxicity compounds supplied as pre-dissolved Solutions or Solid.
Solution: 476 compounds supplied in 10 mM solution, 9 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

COX (29)

HIV (20)

PPAR (15)

AMPK (5)

EGFR (5)

HBV (5)

Akt (4)

HSV (4)

mTOR (4)

PKC (4)

COMT (3)

JNK (3)

MEK (3)

MMP (3)

STAT (3)

FGFR (2)

FKBP (2)

HSP (2)

PARP (2)

PDHK (2)

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Mitochondrial Toxicity Compound Library
    目录号：
    HY-L155
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