2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. JTV-519 hemifumarate

JTV-519 hemifumarate  (Synonyms: K201 hemifumarate)

目录号: HY-15293B 纯度: 98.69%
COA 产品使用指南

摩尔计算器

JTV-519 hemifumarate (K201 hemifumarate) 是 Ca2+ 依赖性的肌质网 Ca2+ 刺激的 ATP 酶 (SERCA) 阻断剂。JTV-519 hemifumarate (K201 hemifumarate) 也是横纹肌中兰尼碱受体 (ryanodine receptors) 的部分激动剂。JTV-519 hemifumarate (K201 hemifumarate) 是一种心脏保护剂，具有抗心律失常作用。

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JTV-519 hemifumarate Chemical Structure

JTV-519 hemifumarate Chemical Structure

CAS No. : 1435938-25-2

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规格 价格 是否有货 数量
5 mg ￥750
In-stock
10 mg ￥1200
In-stock
25 mg ￥2500
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50 mg ￥4200
In-stock
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Customer Review

Other Forms of JTV-519 hemifumarate:

JTV-519 hemifumarate 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2].

体外研究
(In Vitro)

JTV-519 (K201) inhibits inward Ca2+ movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca2+, 3 μM JTV-519 shows significant inhibition of Ca2+ movement due to annexin V, and 50% inhibition is achieved at 25 μM K201[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JTV-519 hemifumarate 相关抗体:
体内研究
(In Vivo)

JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP) [3]
Dosage: 0.5 mg/kg/h
Administration: Applied intraperitoneally 2 h before the surgery
Result: Improved cardiac function, where the EF and FS were significantly increased.
Clinical Trial
分子量

482.64

Formula

C25H32N2O2S.1/2C4H4O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (207.19 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0719 mL 10.3597 mL 20.7194 mL
5 mM 0.4144 mL 2.0719 mL 4.1439 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

JTV-519 hemifumarate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0719 mL 10.3597 mL 20.7194 mL 51.7984 mL
5 mM 0.4144 mL 2.0719 mL 4.1439 mL 10.3597 mL
10 mM 0.2072 mL 1.0360 mL 2.0719 mL 5.1798 mL
15 mM 0.1381 mL 0.6906 mL 1.3813 mL 3.4532 mL
20 mM 0.1036 mL 0.5180 mL 1.0360 mL 2.5899 mL
25 mM 0.0829 mL 0.4144 mL 0.8288 mL 2.0719 mL
30 mM 0.0691 mL 0.3453 mL 0.6906 mL 1.7266 mL
40 mM 0.0518 mL 0.2590 mL 0.5180 mL 1.2950 mL
50 mM 0.0414 mL 0.2072 mL 0.4144 mL 1.0360 mL
60 mM 0.0345 mL 0.1727 mL 0.3453 mL 0.8633 mL
80 mM 0.0259 mL 0.1295 mL 0.2590 mL 0.6475 mL
100 mM 0.0207 mL 0.1036 mL 0.2072 mL 0.5180 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JTV-519 hemifumarate1435938-25-2K201 hemifumarateCalcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-15293B
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