2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. (17R,18S)-Epoxyeicosatetraenoic acid

(17R,18S)-Epoxyeicosatetraenoic acid  (Synonyms: 17(R),18(S)-EETeTr)

目录号: HY-113040A 纯度: ≥93.0%
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(17R,18S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EETeTr) 是二十碳五烯酸 (HY-B0660) 的细胞色素 P450 环氧化酶代谢物。(17R,18S)-Epoxyeicosatetraenoic acid具有负变时作用，可保护新生大鼠心肌细胞免受 Ca2+ 超载。(17R,18S)-Epoxyeicosatetraenoic acid 具有抗心律失常药物研究的潜力。

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(17R,18S)-Epoxyeicosatetraenoic acid Chemical Structure

(17R,18S)-Epoxyeicosatetraenoic acid Chemical Structure

CAS No. : 725246-18-4

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规格 价格 是否有货 数量
25 μg (314.02 μM * 250 μL in Ethanol) ￥1500
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(17R,18S)-Epoxyeicosatetraenoic acid 相关抗体

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生物活性

(17R,18S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EETeTr) is a cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid (HY-B0660). (17R,18S)-Epoxyeicosatetraenoic acid shows exerts negative chronotropic effects and protects neonatal rat cardiomyocytes against Ca2+ overload. (17R,18S)-Epoxyeicosatetraenoic acid has the potential for the research of antiarrhythmic agent[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Cardiac muscle cell EC50
1 nM
Compound: 2, [17(R),18(S)-EETeTr]
Negative chronotropic activity in neonatal Wistar rat Cardiomyocytes assessed as change in heart beating after 5 mins at 37 degC
Negative chronotropic activity in neonatal Wistar rat Cardiomyocytes assessed as change in heart beating after 5 mins at 37 degC
[PMID: 21591683]
分子量

318.45

Formula

C20H30O3
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥93.0%

COA (277 KB)

产品使用指南 (1538 KB)
参考文献

(17R,18S)-Epoxyeicosatetraenoic acid 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(17R,18S)-Epoxyeicosatetraenoic acid725246-18-417(R),18(S)-EETeTrCalcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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