2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. GB-110

GB-110 是一种有效的，具有口服活性的，非肽类的 protease activated receptor 2 (PAR2) 激动剂，选择性诱导 PAR2 介导的 HT29 细胞内 Ca2+ 释放，EC50 值为 0.28 μM。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 GB-110 hydrochloride 通常具有更好的水溶性和稳定性。

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GB-110 Chemical Structure

GB-110 Chemical Structure

CAS No. : 1252806-70-4

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     可免费申领三个不同产品的试用装。

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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GB-110 的其他形式现货产品:

Customer Review

Other Forms of GB-110:

GB-110 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Protease Activated Receptor (PAR) 亚型特异性产品:

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PAR1 PAR2 PAR4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM[1].

IC50 & Target

PAR2

.28 μM (EC50)

体外研究
(In Vitro)

In an intracellular Ca2+ (iCa2+) mobilization assay using HT29 colon cancer cells, GB110 (EC50 240±20 nM; pEC50 6.7±0.05) is equipotent with the peptide agonist 2f-LIGRLO-NH2 (EC50 210±30 nM; pEC50 6.6±0.05), 10-fold more potent than SLIGRL-NH2, but ~35-fold less potent than trypsin (EC50 6±0.5 nM; pEC50 8.2±0.8)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GB-110 相关抗体:
分子量

608.77

Formula

C33H48N6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GB-110 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GB-1101252806-70-4GB110GB 110Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-120528
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