Diphenidol 

Diphenidol is a non-selective muscarinic M₁-M₄ receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na⁺, K⁺, and Ca²⁺) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea^{[1][2][3][4][5]}.

Diphenidol 可抑制钠电流并产生脊髓麻醉，在 -70 和 -100 mV 保持电位下，对小鼠神经母细胞瘤 N2A 细胞 IC₅₀ 分别为 0.77 和 62.6 μM^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diphenidol (2, 10 μmoL/kg, 腹腔注射) 可降低慢性收缩损伤后大鼠的神经性异常痛和 TNF-α 过表达^[4]。
Diphenidol (30 mg/kg, 静脉注射) 对运动和阿吗啡诱导的异食癖大鼠呕吐具有抑制作用^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

309.45

C₂₁H₂₇NO

972-02-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44.  [Content Brief]

  [2]. Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52.  [Content Brief]

  [3]. Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52.  [Content Brief]

  [4]. Chen YW, et al. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27;552:62-5.  [Content Brief]

  [5]. Takeda N, et al. Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats. Methods Find Exp Clin Pharmacol. 1995 Nov;17(9):589-90.  [Content Brief]