2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. SR33805 oxalate

SR33805 oxalate 是一种有效的 Ca2+ 通道拮抗剂，在去极化和极化条件下的 EC50 值分别为 4.1 nM 和 33 nM。SR33805 oxalate 阻止 L 型而不是 T 型 Ca2+ 通道。SR33805 oxalate 可用于研究急性或慢性心脏衰竭。

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SR33805 oxalate Chemical Structure

SR33805 oxalate Chemical Structure

CAS No. : 121346-33-6

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Other Forms of SR33805 oxalate:

SR33805 oxalate 相关抗体

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SR33805 oxalate is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 oxalate blocks L-type but not T-type Ca2+ channels. SR33805 oxalate can be used for the research of acute or chronic failing hearts[1][2].

体外研究
(In Vitro)

SR33805 (0.01-10 µM；3天) oxalate 以剂量依赖的方式抑制生长因子诱导的SMC增殖 (0.20< IC50<0.46 µM)[2]。
SR33805 (10 µM；10分钟) oxalate 恢复心肌梗死 (MI) 改变的细胞收缩，而不影响Ca2+ 瞬态幅度[2]。
SR33805 (10 µM) oxalate降低重组PKA的活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SR33805 oxalate 相关抗体:

Cell Viability Assay[3]

Cell Line: Smooth muscle cells (SMC).
Concentration: 0.01, 0.1, 1, 10 µM.
Incubation Time: 3 days.
Result: Inhibited in a dose-dependent manner FCS-, bFGF and PDGF-induced proliferation of porcine SMC with IC50s of 0.26±0.08, 0.46±0.1 and 0.20±0.04 µM, respectively.
体内研究
(In Vivo)

SR33805 (20 mg/kg；单次腹腔注射) 改善大鼠心肌梗死 (MI) 心脏的收缩末期应变和短轴缩短分数[2]。
SR33805 (5 mg/kg/天；口服38天) 显著减少猪的内膜增生[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (5 weeks) are subjected to coronary artery ligature[2].
Dosage: 0.2, 2, 20 mg/kg.
Administration: A single i.p. injection.
Result: Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg
Did not affect other contractile parameters.
分子量

654.77

Formula

C34H42N2O9S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SR33805 oxalate 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR33805121346-33-6SR 33805SR-33805Calcium ChannelCa2+ channelsCa channelsCa2+channeldepolarizedpolarizedL-typeacutechronicfailingheartsInhibitorinhibitorinhibit

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产品名称：
SR33805 oxalate
目录号：
HY-103313
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