2. Metabolic Enzyme/Protease
  3. Glucokinase
  4. GKA50 quarterhydrate

GKA50 quarterhydrate 是一种有效的葡萄糖激酶 (glucokinase) 激活剂 (EC50=33 nM)。GKA50 quarterhydrate 刺激小鼠胰岛分泌胰岛素。GKA50 quarterhydrate 是啮齿动物和人类胰岛中 β 细胞代谢的葡萄糖样激活剂，以及 Ca2+ 依赖性胰岛素分泌调节剂。GKA50 quarterhydrate 对高脂喂养的雌性大鼠血糖有显著的降低作用。

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GKA50 quarterhydrate Chemical Structure

GKA50 quarterhydrate Chemical Structure

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规格 价格 是否有货
1 mg ￥1850
询问价格 & 货期
5 mg ￥5500
询问价格 & 货期

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GKA50 quarterhydrate 的其他形式现货产品:

Customer Review

Other Forms of GKA50 quarterhydrate:

GKA50 quarterhydrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca2+-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats[1][2][3][4].

体外研究
(In Vitro)

GKA50 (0.01-100 μM; 24 hours) enhances INS-1 cell proliferation with EC50 values ranging from 1 to 2 μM[2].
GKA50 (1.2 μM+40 μM glucose; 2-4 days) treatment reduces apoptosis induced by chronic high glucose in INS-1 cells[2].
GKA50 activates human glucokinase enzymatic activity with an EC50 of 0.022 μM. GKA50 stimulates insulin secretion in the pancreatic insulinoma cell line, INS-1, with an EC50 of 0.065 μM. GKA50 reduces chronic-high-glucose-induced apoptosis via modulation of glucokinase and apoptotic protein BAD[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GKA50 quarterhydrate 相关抗体:

Cell Proliferation Assay[2]

Cell Line: INS-1 cells (starved overnight with 3 μM glucose)
Concentration: 0.01-100 μM
Incubation Time: 24 hours
Result: Stimulated cell proliferation in a dose-dependent manner, with EC50 values ranging from 1 to 2 μM.
体内研究
(In Vivo)

GKA50 (1-30 mg/kg; p.o.) gives significant glucose lowering in an oral glucose tolerance test[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat-fed obese female Zucker (fa/fa) rats[1]
Dosage: 1, 3, 10, 30 mg/kg
Administration: Oral administration
Result: Significant percentage glucose lowering.
分子量

469.01

Formula

C26H28N2O6.1/4H2O
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 46 mg/mL (98.08 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1322 mL 10.6608 mL 21.3215 mL
5 mM 0.4264 mL 2.1322 mL 4.2643 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (268 KB) 元素分析报告 (214 KB)

产品使用指南 (1538 KB)
参考文献

GKA50 quarterhydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1322 mL 10.6608 mL 21.3215 mL 53.3038 mL
5 mM 0.4264 mL 2.1322 mL 4.2643 mL 10.6608 mL
10 mM 0.2132 mL 1.0661 mL 2.1322 mL 5.3304 mL
15 mM 0.1421 mL 0.7107 mL 1.4214 mL 3.5536 mL
20 mM 0.1066 mL 0.5330 mL 1.0661 mL 2.6652 mL
25 mM 0.0853 mL 0.4264 mL 0.8529 mL 2.1322 mL
30 mM 0.0711 mL 0.3554 mL 0.7107 mL 1.7768 mL
40 mM 0.0533 mL 0.2665 mL 0.5330 mL 1.3326 mL
50 mM 0.0426 mL 0.2132 mL 0.4264 mL 1.0661 mL
60 mM 0.0355 mL 0.1777 mL 0.3554 mL 0.8884 mL
80 mM 0.0267 mL 0.1333 mL 0.2665 mL 0.6663 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GKA50 quarterhydrateGlucokinaseHexokinase IVHexokinase DglucoseinsulinMIN6highfatfedsecretionproliferationβ-cellsINS-1Inhibitorinhibitorinhibit

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产品名称：
GKA50 quarterhydrate
目录号：
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