2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. AP14145

AP14145 是小电导钙激活的钾离子通道 (small conductance calcium-activated potassium channel) 的抑制剂，抑制 KCa2.2 通道 (KCa2.2 channel) 和 KCa2.3 通道 (KCa2.3 channel)，IC50 分别为 1.1 μM 和 1.1 μM。AP14145 可延长大鼠心房有效不应期 (AERP)，在猪左心室功能障碍模型中可将房颤转化为窦性心律，并表现出抗心律失常作用。

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AP14145 Chemical Structure

AP14145 Chemical Structure

CAS No. : 1446770-54-2

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AP14145 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa channel with IC50 of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect[1][2].

分子量

362.35

Formula

C18H17F3N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AP14145 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

AP141451446770-54-2AP 14145AP-14145Potassium ChannelKcsAPorcinepigleft ventricular dysfunctionLVDsinus rhythmatrial fibrillationInhibitorinhibitorinhibit

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