2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Nemadipine-A

Nemadipine-A 是 EGL-19 Ca2+ 通道 (Ca2+ channel) 的特异性抑制剂。Nemadipine-A 是一种细胞渗透性 L 型钙通道抑制剂，可使对 TRAIL 抗性的癌细胞对该配体敏感。

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Nemadipine-A Chemical Structure

Nemadipine-A Chemical Structure

CAS No. : 54280-71-6

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5 mg ￥1426
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Nemadipine-A 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel[1]. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand[2].

体外研究
(In Vitro)

Nemadipine-A is a specific and highly effective inhibitor of EGL-19. Nemadipine-A (µM) is sufficient to abolish the enhanced level of paralysis observed in egl-19(ad695); crIs4 mutants[1].
Nemadipine-A strongly potentiates TRAIL-induced apoptosis in TRAIL-resistant lung cancer cells via the down-regulation of the anti-apoptotic protein survivin[2]. Nemadipine-A sensitizes H1299 lung cancer cells towards TRAIL-induced cytotoxicity[2]. Combination of Nemadipine-A (20 μM) with TRAIL (20 ng/mL) induces caspase-mediated apoptotic cell death[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nemadipine-A 相关抗体:

Cell Viability Assay[2]

Cell Line: H1299 lung adenocarcinoma cells
Concentration: 0, 5, 10, 20, and 30 μM
Incubation Time: 8 hours
Result: H1299 cells were resistant to the apoptotic effects of TRAIL, but the co-administration of Nemadipine-A and TRAIL in these cells resulted in notably increased cytotoxicity in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: H1299 cells
Concentration: 20 μM
Incubation Time: 8 hours
Result: Co-treated with TRAIL and Nemadipine-A (T/N; 20 ng/mL and 20 μM respectively) induced cell death in H1299 cells.
分子量

419.34

Formula

C19H18F5NO4
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 20 mg/mL (47.69 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3847 mL 11.9235 mL 23.8470 mL
5 mM 0.4769 mL 2.3847 mL 4.7694 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.0%

COA (289 KB)

产品使用指南 (1538 KB)
参考文献

Nemadipine-A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3847 mL 11.9235 mL 23.8470 mL 59.6175 mL
5 mM 0.4769 mL 2.3847 mL 4.7694 mL 11.9235 mL
10 mM 0.2385 mL 1.1923 mL 2.3847 mL 5.9617 mL
15 mM 0.1590 mL 0.7949 mL 1.5898 mL 3.9745 mL
20 mM 0.1192 mL 0.5962 mL 1.1923 mL 2.9809 mL
25 mM 0.0954 mL 0.4769 mL 0.9539 mL 2.3847 mL
30 mM 0.0795 mL 0.3974 mL 0.7949 mL 1.9872 mL
40 mM 0.0596 mL 0.2981 mL 0.5962 mL 1.4904 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemadipine-A54280-71-6Calcium ChannelCa2+ channelsCa channelsEGL-19L-typeCa2+channelcalciumTRAILresistantcancerSensitizationH1299Inhibitorinhibitorinhibit

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