2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. AVE-0118

AVE-0118 是一种非选择性 Kv1.5 阻滞剂，IC50 为1.1 μM。AVE-0118 是一种多通道抑制剂，对 Kv1.5 和其他离子通道具有弱的微摩尔活性。它对 IKs、IKATP 和 l 型 Ca+ 通道无活性。

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AVE-0118 Chemical Structure

AVE-0118 Chemical Structure

CAS No. : 498577-53-0

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规格 价格 是否有货 数量
1 mg ￥797
1 - 2 周
5 mg   询价  
10 mg   询价  

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Customer Review

AVE-0118 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AVE-0118 is a nonselective Kv1.5 blocker with an IC50 of 1.1 μM. AVE-0118 is a multichannel inhibitor with weak, micromolar activity against Kv1.5 and other ion channels. It is inactive against IKs, IKATP, and L-type Ca+ channels[1].

IC50 & Target

IC50: 1.1 μM (Kv1.5), 3.4 uM (Ito), 4.5 uM (IKAch), 8.4 uM (IKr)[1]
体外研究
(In Vitro)

AVE-0118 是一种 Kv1.5 阻滞剂 (IC50 = 1.1 uM)，对 Ito (3.4 uM)、IKr (8.4 uM) 和 IKAch (4.5 uM) 具有中等选择性，对IKs、IK1、IKATP 具有良好的选择性[1]。
AVE-0118 (10 μM) 显著增强电场刺激 (EFS) 诱导的神经源性收缩[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AVE-0118 相关抗体:
体内研究
(In Vivo)

在 3 mg/kg 剂量下，AVE-0118 降低了心房重构山羊 AF 的诱导性，在 5mg/kg 也并没有延长 QTc[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

479.57

Formula

C30H29N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AVE-0118 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AVE-0118498577-53-0AVE0118AVE 0118Potassium ChannelKcsAInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
AVE-0118
目录号：
HY-118387
需求量：

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