2. Membrane Transporter/Ion Channel
  3. CRAC Channel
  4. Tanshinone IIA sulfonate sodium

Tanshinone IIA sulfonate sodium  (Synonyms: 丹参酮IIA磺酸盐; Sodium Tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate)

目录号: HY-N1370 纯度: 98.83%
COA 产品使用指南

摩尔计算器

Tanshinone IIA sulfonate sodium 是 tanshinone IIA 的衍生物，为 SOCE 的抑制剂，用于心血管疾病的研究。

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Tanshinone IIA sulfonate sodium Chemical Structure

Tanshinone IIA sulfonate sodium Chemical Structure

CAS No. : 69659-80-9

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10 mg ￥500
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25 mg ￥800
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Customer Review

Tanshinone IIA sulfonate sodium 相关抗体

Top Publications Citing Use of Products

    Tanshinone IIA sulfonate sodium purchased from MCE. Usage Cited in: Int Immunopharmacol. 2023 Apr 5;118:110111.  [Abstract]

    Tanshinone IIA sulfonate sodium (STS; 10-50 μM; 24 h) induces significant cell death in BV2 cells.

    Tanshinone IIA sulfonate sodium purchased from MCE. Usage Cited in: Int Immunopharmacol. 2023 Apr 5;118:110111.  [Abstract]

    Tanshinone IIA sulfonate sodium (STS; 5, 10 μM; 24 h) decreases the expression of iNOS in a dose-dependent manner in BV2 cells.

    Tanshinone IIA sulfonate sodium purchased from MCE. Usage Cited in: J Cell Mol Med. 2020 Mar;24(6):3328-3335.  [Abstract]

    STS improves the protein expressions of Aβ degrading enzymes in Aβ-treated SH-SY5Y cells. NEP (A) and IDE (B) protein levels are detected by Western blotting in SH-SY5Y cells. STS-L: 1 µmol/L, STS-M: 10 µmol/L, STS-H: 100 µmol/L.

    Tanshinone IIA sulfonate sodium purchased from MCE. Usage Cited in: J Cell Mol Med. 2020 Mar;24(6):3328-3335.  [Abstract]

    STS protects against Aβ-induced cell toxicity in SH-SY5Y cells. (A) MTS cell viability assay is performed in SH-SY5Y cells after exposure to different concentrations of Aβ (1.25, 2.5, 5, 10 and 20 µmol/L) for 24 h. (B) MTS cell viability of Aβ (10 µmol/L)-treated SY5Y cells after STS preprotection. STS-L: 1 µmol/L, STS-M: 10 µmol/L, STS-H: 100 µmol/L.

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.

    体外研究
    (In Vitro)

    Sodium Tanshinone IIA sulfonate (12.5 μM) inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs and distal pulmonary arteries of rats. The suppressive effects of Sodium Tanshinone IIA sulfonate on TRPC1 and TRPC6 expression in hypoxic PASMCs can be prevented by specific knockdown PKG or PPAR-γ. The suppressive effects of Sodium Tanshinone IIA sulfonate on basal calcium concentration and SOCE in hypoxic PASMCs can be reversed by specific knockdown of PKG or PPAR-γ. PKG-PPAR-γ signaling axis participates in the suppressive effects of Sodium Tanshinone IIA sulfonate on proliferation in hypoxic PASMCs. PPAR-γ agonist promotes the protective role of Sodium Tanshinone IIA sulfonate on basal [Ca2+]i and SOCE in hypoxic PASMCs[2]. Sodium tanshinone IIA sulfonate inhibits the activity of CYP3A4 in a dose-dependent manner by the HLMs and CYP3A4 isoform. The KM and Vmax values of STS are 54.8±14.6 µM and 0.9±0.1 nmol/mg protein/min, respectively, for the HLMs and 7.5±1.4 µM and 6.8±0.3 nmol/nmol P450/min, respectively, for CYP3A4. CYP1A2, CYP2A6, CYP2C9, CYP2D6, CYP2E1, and CYP2C19 show minimal or no effects on the metabolism of STS[3]. Sodium Tanshinone IIA sulfonate inhibits the activity of CYP3A4 in a dose-dependent manner in the HLMs and CYP3A4 isoform. Sodium Tanshinone IIA sulfonate primarily inhibits the activities of CYP3A4 in vitro, and Sodium Tanshinone IIA sulfonate has the potential to perpetrate drug-drug interactions with other CYP3A4 substrates[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Tanshinone IIA sulfonate sodium 相关抗体:
    体内研究
    (In Vivo)

    Sodium Tanshinone IIA sulfonate (10 mg/kg, 20 mg/kg) and Donepezil shorten escape latency, increase crossing times of the original position of the platform, and increase the time spent in the target quadrant. Sodium Tanshinone IIA sulfonate decreases the activity of acetylcholinesterase (AChE) and increases the activity of choline acetyltransferase (ChAT) in the hippocampus and cortex of SCOP-treated mice. Sodium Tanshinone IIA sulfonate increases the activity of superoxide dismutase (SOD) and decreases the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in hippocampus and cortex[1]. Sodium Tanshinone IIA sulfonate prevention (30 mg/kg/day) alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat model[2]. Sodium Tanshinone IIA sulfonate (20, 10, and 5 mg/kg, i.p.) effectively prevents peritoneal adhesion without affecting anastomotic healing in the rats. Compared with the adhesion model group, the Sodium Tanshinone IIA sulfonate-treated groups show increased peritoneal lavage fluid tPA activity and tPA/PAI-1 ratio in the ischemic tissues with loared TGF-β1 and collagen I expressions in the ischemic tissues[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    396.39

    Formula

    C19H17NaO6S
    CAS 号
    性状

    固体

    颜色

    Pink to red

    中文名称

    丹参酮IIA磺酸盐
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 62.5 mg/mL (157.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    H2O 中的溶解度 : 2 mg/mL (5.05 mM; 超声助溶 (<60°C))

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.5228 mL 12.6138 mL 25.2277 mL
    5 mM 0.5046 mL 2.5228 mL 5.0455 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    请根据您的 实验动物和给药方式 选择适当的溶解方案。

    以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
    以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 方案 一

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (5.25 mM); 澄清溶液

      此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

      20% SBE-β-CD in Saline 的配制（4°C，储存一周）：2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
    • 方案 二

      请依序添加每种溶剂： 10% DMSO    90% Corn Oil

      Solubility: 2.08 mg/mL (5.25 mM); 悬浊液; 超声助溶

      此方案可获得 2.08 mg/mL的均匀悬浊液，悬浊液可用于口服和腹腔注射。

      以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    请输入您的动物体内配方组成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
    方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
    计算结果
    工作液所需浓度 : mg/mL
    储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。

    *该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
    动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
    连续给药周期超过半月以上，请谨慎选择该方案。
    请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
    纯度 & 产品资料

    纯度: 98.83%

    COA (213 KB) HNMR (280 KB) LCMS (98 KB)

    产品使用指南 (1538 KB)
    参考文献
    Animal Administration
    [1][2]

    Mice[1]
    Male Kunming mice (KM, weighing 35-40 g) are maintained on standard laboratory conditions with free access to water and food. Mice are randomly divided into five groups: vehicle control group (CON, 0.9% saline, n=10), scopolamine group (SCOP, n=10), low dose Sodium Tanshinone IIA sulfonate group (Sodium Tanshinone IIA sulfonate L, SCOP 3 mg/kg + Sodium Tanshinone IIA sulfonate 10 mg/kg, n=10), high dose Sodium Tanshinone IIA sulfonate group (Sodium Tanshinone IIA sulfonate H, SCOP 3 mg/kg + Sodium Tanshinone IIA sulfonate 20 mg/kg, n=10), and Donepezil group (DON, SCOP 3 mg/kg + ARI 3 mg/kg, n=10). Mice are treated with saline, Sodium Tanshinone IIA sulfonate, and Donepezil, respectively, by gavage, once per day for two weeks. SCOP is injected from the eighth day for one week (intraperitoneally, IP). The SCOP is injected 0.5 h before the Morris water maze test.
    Rats[2]
    Male Sprague-Dawley rats (200-250 g) are randomly divided into four groups by the random number table: 1) normoxia control group, 2) normoxia + Sodium Tanshinone IIA sulfonate group, 3) hypoxia control group, and 4) hypoxia + Sodium Tanshinone IIA sulfonate group. Groups 1 and 2 are placed in normoxic condition and groups 3 and 4 in a hypoxic cabin with normal pressure, as previously reported, where the oxygen concentration is maintained at 10±1%, in a sustained hypoxic condition for 21 days. Groups 2 and 4, starting from the first day of hypoxia, are, respectively, intraperitoneally injected with 30 mg/kg tanshinone IIA sulfonate; meanwhile, groups 1 and 3 receive the same dose of saline.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Tanshinone IIA sulfonate sodium 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.5228 mL 12.6138 mL 25.2277 mL 63.0692 mL
    5 mM 0.5046 mL 2.5228 mL 5.0455 mL 12.6138 mL
    DMSO 10 mM 0.2523 mL 1.2614 mL 2.5228 mL 6.3069 mL
    15 mM 0.1682 mL 0.8409 mL 1.6818 mL 4.2046 mL
    20 mM 0.1261 mL 0.6307 mL 1.2614 mL 3.1535 mL
    25 mM 0.1009 mL 0.5046 mL 1.0091 mL 2.5228 mL
    30 mM 0.0841 mL 0.4205 mL 0.8409 mL 2.1023 mL
    40 mM 0.0631 mL 0.3153 mL 0.6307 mL 1.5767 mL
    50 mM 0.0505 mL 0.2523 mL 0.5046 mL 1.2614 mL
    60 mM 0.0420 mL 0.2102 mL 0.4205 mL 1.0512 mL
    80 mM 0.0315 mL 0.1577 mL 0.3153 mL 0.7884 mL
    100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.6307 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tanshinone IIA sulfonate69659-80-9Sodium Tanshinone IIA sulfonate Tanshinone IIA sodium sulfonate丹参酮IIA磺酸盐CRAC ChannelCalcium release-activated channelsCa2+ release-activated Ca2+ channelsInhibitorinhibitorinhibit

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