CLTC - clathrin heavy chain Gene

中文名称：网格蛋白重链

种属: Homo sapiens

同用名: Hc; CHC; CHC17; MRD56; CLH-17; CLTCL2

基因 ID: 1213 | 基因类型: protein coding

关于 CLTC

Cytogenetic location: 17q23.1 Genomic coordinates (GRCh38): 17:59,619,895-59,696,956 (from NCBI)

This gene has 23 transcripts (splice variants), 298 orthologues, 2 paralogues and is associated with 93 phenotypes. Ubiquitous expression in brain (RPKM 67.0), thyroid (RPKM 49.4) and 25 other tissues.

功能概要

网格蛋白是细胞内细胞器细胞质面的主要蛋白质成分，称为包被囊泡和包被凹坑。这些专门的细胞器参与受体的细胞内运输和各种大分子的内吞作用。网格蛋白外套的基本亚基由三个重链和三个轻链组成。[RefSeq 提供，2008 年 7 月]

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three LIGHT chains. [provided by RefSeq, Jul 2008]

CLTC 基因产物(2)

mRNA	Protein	Name
NM_001288653.2	NP_001275582.1	clathrin heavy chain 1 isoform 2
NM_004859.4	NP_004850.1	clathrin heavy chain 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables clathrin light chain binding	IPI IPI: 通过物理相互作用推断	4066749	GOA
enables disordered domain specific binding	IPI IPI: 通过物理相互作用推断	11756460	GOA
enables double-stranded RNA binding	IDA IDA: 通过直接分析推断	21266579	GOA
enables low-density lipoprotein particle receptor binding	IPI IPI: 通过物理相互作用推断	26005850	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12429846	GOA
enables ubiquitin-specific protease binding	IPI IPI: 通过物理相互作用推断	26756164	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in amyloid-beta clearance by transcytosis	IMP IMP: 通过突变表型推断	26005850	GOA
involved in clathrin coat assembly	IMP IMP: 通过突变表型推断	11756460	GOA
involved in clathrin-dependent endocytosis	IMP IMP: 通过突变表型推断	26005850	GOA
involved in mitotic cell cycle	IMP IMP: 通过突变表型推断	15858577	GOA
involved in negative regulation of hyaluronan biosynthetic process	IDA IDA: 通过直接分析推断	24251095	GOA
involved in negative regulation of hyaluronan biosynthetic process	IMP IMP: 通过突变表型推断	23509262	GOA
involved in negative regulation of protein localization to plasma membrane	IMP IMP: 通过突变表型推断	19581412	GOA
involved in receptor internalization	IMP IMP: 通过突变表型推断	14985334	GOA
involved in receptor-mediated endocytosis	IMP IMP: 通过突变表型推断	15858577	GOA
involved in regulation of mitotic spindle organization	IMP IMP: 通过突变表型推断	21297582	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: 通过突变表型推断	20065094	GOA
involved in transferrin transport	IMP IMP: 通过突变表型推断	14985334	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of clathrin coat	IMP IMP: 通过突变表型推断	11756460	GOA
part of clathrin complex	IDA IDA: 通过直接分析推断	4066749	GOA
located in clathrin-coated vesicle	IDA IDA: 通过直接分析推断	19478182	GOA
located in mitotic spindle microtubule	IDA IDA: 通过直接分析推断	21297582	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	21266579	GOA
located in spindle	IDA IDA: 通过直接分析推断	15858577	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLTC 蛋白结构

Clathrin_propel

Clathrin-link

Clathrin_H_link

Clathrin

0
300
600
900
1200
1500
1675 a.a.

蛋白主名

其他名称

clathrin heavy chain 1

clathrin heavy chain on chromosome 17

CLTC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CLTC	Q00610	CLTA	Homo sapiens	P09496	Anti Tag CoIP	35271311
Intra	CLTC	Q00610	CLTA	Homo sapiens	P09496	Crosslink	30021884
Intra	CLTC	Q00610	MYB	Homo sapiens	P10242	Anti Bait CoIP	18548008
Intra	CLTC	Q00610	TNK2	Homo sapiens	Q07912	Pull Down	19798056
Intra	CLTC	Q00610	TNK2	Homo sapiens	Q07912	Anti Tag CoIP	26496610
Intra	CLTC	Q00610	OCRL	Homo sapiens	Q01968	SPR	19536138
Intra	CLTC	Q00610	OCRL	Homo sapiens	Q01968	Anti Tag CoIP	26496610
Intra	CLTC	Q00610	OCRL	Homo sapiens	Q01968	Pull Down	16902405
Intra	CLTC	Q00610	ARRB2	Homo sapiens	P32121	FPS	37100772
Intra	CLTC	Q00610	ARRB2	Homo sapiens	P32121	Phage Display	35044719
Intra	CLTC	Q00610	PAAT	Homo sapiens	Q9H8K7	Anti Tag CoIP	26496610
Intra	CLTC	Q00610	DLGAP5	Homo sapiens	Q15398	X-Ray Diffraction	37219487
Intra	CLTC	Q00610	DLGAP5	Homo sapiens	Q15398	Anti Tag CoIP	37219487
Intra	CLTC	Q00610	DLGAP5	Homo sapiens	Q15398	FPS	37219487
Intra	CLTC	Q00610	DLGAP5	Homo sapiens	Q15398	ITC	37219487
Cross	CLTC	Q00610	poln_eeev8	Eastern equine encephalitis virus	Q306W8	Phage Display	37100772
Cross	CLTC	Q00610	poln_eeev8	Eastern equine encephalitis virus	Q306W8	X-Ray Diffraction	37100772
Cross	CLTC	Q00610	poln_eeev1	Eastern equine encephalitis virus	Q306W6	FPS	37219487

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, Autosomal Dominant 56

Mental Retardation, Autosomal Dominant 56	MRD56
Autosomal Dominant Mental Retardation 56	Autosomal Dominant Intellectual Developmental Disorder 56
Autosomal Dominant Intellectual Developmental Disorder-56

Autosomal Dominant Non-Syndromic Intellectual Disability

Renal Cell Carcinoma, Xp11-Associated

RCCX1	Mit Family Translocation Renal Cell Carcinoma
Renal Cell Carcinoma, Papillary, 1	Carcinoma Associated With Mitf/Tfe Translocation
Translocation Renal Cell Carcinoma	Renal Cell Carcinoma Xp11-Associated
Renal Cell Carcinoma Papillary 1	Carcinoma, Renal Cell, Xp11-Associated

Noonan Syndrome 3

NS3	Noonan Syndrome, Type 3

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy	Non-Specific Eoee
Undetermined Eoee

Pulmonary Plasma Cell Granuloma

Plasma Cell Granuloma, Pulmonary	Granuloma, Plasma Cell, Pulmonary
Lymphocytic Pseudotumor Of Lung	Sclerosing Hemangiocytoma Of Lung

Epithelioid Inflammatory Myofibroblastic Sarcoma

Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive	Arh
FHCL4	Autosomal Recessive Hypercholesterolemia
Arh1	Arh2
Autosomal Recessive Hypercholesterolemia 1	Autosomal Recessive Hypercholesterolemia 2
Fhcb1	Fhcb2
Hypercholesterolemia, Autosomal Recessive, 1, Formerly	Arh1, Formerly
Fhcb1, Formerly	Hypercholesterolemia, Autosomal Recessive, 2, Formerly
Arh2, Formerly	Fhcb2, Formerly
Familial Autosomal Recessive Hypercholesterolemia	Hypercholesterolemia, Familial, Autosomal Recessive
Hypercholesterolemia, Familial, Type 4

Childhood Kidney Cell Carcinoma

Pediatric Renal Cell Carcinoma

Childhood Renal Cell Carcinoma

Alveolar Soft Part Sarcoma

ASPS	Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part	Alveolar Soft Tissue Sarcoma
Sarcoma Alveolar Soft Part	Adult Alveolar Soft-Part Sarcoma
Childhood Alveolar Soft-Part Sarcoma

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor	Mesenchymal Tumor
Mesenchymal Tumors

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02845	CLTC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CLTC	VGNC	VGNC:39367
Mus musculus	CLTC	MGD	MGI:2388633
Bos taurus	CLTC	VGNC	VGNC:27471
Rattus norvegicus	CLTC	RGD	RGD:2364
Felis catus	CLTC	VGNC	VGNC:60984
Macaca mulatta	CLTC	VGNC	VGNC:97754

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CLTC - clathrin heavy chain Gene

关于 CLTC

功能概要

CLTC 基因产物(2)

CLTC 蛋白结构

CLTC 蛋白互作信息

关联疾病

直系同源

热门区域

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CLTC - clathrin heavy chain Gene

关于 CLTC

功能概要

CLTC 基因产物(2)

CLTC 蛋白结构

CLTC 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

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