2. Gene
  3. ARRB2 - arrestin beta 2 Gene

ARRB2 - arrestin beta 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：抑制蛋白 2

种属: Homo sapiens

同用名: ARB2; ARR2; BARR2

基因 ID: 409 | 基因类型: protein coding

关于 ARRB2

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,710,632-4,721,497 (from NCBI)

This gene has 20 transcripts (splice variants), 247 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 69.2), appendix (RPKM 43.9) and 21 other tissues.

功能概要

Arrestin/beta-arrestin 蛋白家族的成员被认为参与激动剂介导的 G 蛋白偶联受体脱敏，并导致细胞对激素、神经递质或感觉信号等刺激的反应发生特异性抑制。 Arrestin beta 2 与 Arrestin beta 1 一样，在体外显示可抑制 β-肾上腺素能受体功能。它在中枢神经系统中以高水平表达，并可能在突触受体的调节中发挥作用。除大脑外，从甲状腺中分离出抑制蛋白 2 的 cDNA，因此它也可能参与 TSH 受体的激素特异性脱敏。已为该基因发现编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2012 年 3 月]

Members of Arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as Hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like Arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for Arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

ARRB2 基因产物(7)

mRNA Protein Name
NM_001257328.2 NP_001244257.1 beta-arrestin-2 isoform 3
NM_001257329.2 NP_001244258.1 beta-arrestin-2 isoform 4
NM_001257330.2 NP_001244259.1 beta-arrestin-2 isoform 5
NM_001257331.2 NP_001244260.1 beta-arrestin-2 isoform 6
NM_001330064.2 NP_001316993.1 beta-arrestin-2 isoform 7
NM_004313.4 NP_004304.1 beta-arrestin-2 isoform 1
NM_199004.2 NP_945355.1 beta-arrestin-2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D1 dopamine receptor binding IPI
IPI: 通过物理相互作用推断
33571431 GOA
enables G protein-coupled receptor binding IPI
IPI: 通过物理相互作用推断
10644702 GOA
enables angiotensin receptor binding IPI
IPI: 通过物理相互作用推断
15611106 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23382074 GOA
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
26839314 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12958365 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
18604210 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
15878855 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor internalization IDA
IDA: 通过直接分析推断
10644702 GOA
involved in G protein-coupled receptor internalization IMP
IMP: 通过突变表型推断
12582207 GOA
involved in cell chemotaxis IMP
IMP: 通过突变表型推断
15635042 GOA
involved in desensitization of G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
12582207 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
15125834 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
26839314 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
18604210 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
16378096 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
10644702 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
12582207 GOA
involved in positive regulation of receptor internalization IMP
IMP: 通过突变表型推断
22457824 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
15878855 GOA
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
15878855 GOA
involved in receptor internalization IDA
IDA: 通过直接分析推断
12958365 GOA
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16820410 GOA
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
12958365 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12958365 GOA
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
12958365 GOA
located in endocytic vesicle IDA
IDA: 通过直接分析推断
23341447 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16820410 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
18604210 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARRB2 蛋白结构

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (20 - 174)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (195 - 349)

  • 0
  • 100
  • 200
  • 300
  • 409 a.a.
蛋白主名 其他名称

beta-arrestin-2

arrestin 3

ARRB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARRB2 P32121 PPM1B Homo sapiens O75688
Anti Tag CoIP
17620599
Intra ARRB2 P32121 ZRANB2 Homo sapiens O95218
Anti Tag CoIP
17620599
Intra ARRB2 P32121 S100A9 Homo sapiens P06702
Anti Tag CoIP
17620599
Intra ARRB2 P32121 INSR Homo sapiens P06213-1
Anti Bait CoIP
19122674
Intra ARRB2 P32121 PDE4D Homo sapiens Q08499
Anti Bait CoIP
19955404
Intra ARRB2 P32121 PDE4D Homo sapiens Q08499
Anti Tag CoIP
17620599
Cross ARRB2 P32121 Akt1 Mus musculus P31750
Pull Down
16051150
Intra ARRB2 P32121 NCL Homo sapiens P19338
Anti Tag CoIP
17620599
Intra ARRB2 P32121 GSN Homo sapiens P06396
Anti Tag CoIP
17620599
Intra ARRB2 P32121 HSPA8 Homo sapiens P11142
Anti Tag CoIP
17620599
Intra ARRB2 P32121 PKM Homo sapiens P14618
Anti Tag CoIP
17620599
Intra ARRB2 P32121 CLTC Homo sapiens Q00610
FPS
37100772
Intra ARRB2 P32121 YWHAQ Homo sapiens P27348
Anti Tag CoIP
17620599
Intra ARRB2 P32121 PRP4K Homo sapiens Q13523
Anti Tag CoIP
17620599
Intra ARRB2 P32121 TCOF1 Homo sapiens Q13428
Anti Tag CoIP
17620599
Intra ARRB2 P32121 TCOF1 Homo sapiens Q13428
Anti Bait CoIP
17353931
Intra ARRB2 P32121 NOLC1 Homo sapiens Q14978
Anti Bait CoIP
17353931
Intra ARRB2 P32121 NOLC1 Homo sapiens Q14978
Anti Tag CoIP
17620599
Intra ARRB2 P32121 NOLC1 Homo sapiens Q14978
Anti Tag CoIP
33961781
Intra ARRB2 P32121 STK38 Homo sapiens Q15208
Anti Tag CoIP
17620599
Intra ARRB2 P32121 MAP3K5 Homo sapiens Q99683
Peptide Array
19782076
Intra ARRB2 P32121 ADRB2 Homo sapiens P07550
Anti Tag CoIP
23208550
Intra ARRB2 P32121 ADRB2 Homo sapiens P07550
IF
23208550
Intra ARRB2 P32121 SRC Homo sapiens P12931
Anti Bait CoIP
19202075
Cross ARRB2 P32121 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra ARRB2 P32121 EDNRA Homo sapiens P25101
Anti Bait CoIP
19202075
Intra ARRB2 P32121 MAPK9 Homo sapiens P45984
Y2H Array
31515488
Intra ARRB2 P32121 MAPK9 Homo sapiens P45984
Y2H Pooling
19060904
Intra ARRB2 P32121 MAPK9 Homo sapiens P45984
Y2H Array
19060904
Intra ARRB2 P32121 MAPK9 Homo sapiens P45984
Validated Y2H
32296183
Intra ARRB2 P32121 MAPK9 Homo sapiens P45984
Y2H Array
25416956
Intra ARRB2 P32121 MAPK9 Homo sapiens P45984
Y2H Prey Pooling
25416956
Intra ARRB2 P32121 PDE4D Homo sapiens Q08499-2
Anti Tag CoIP
19955404
Intra ARRB2 P32121 PPM1A Homo sapiens P35813
Anti Tag CoIP
17620599
Cross ARRB2 P32121 rl Drosophila melanogaster P40417
Anti Tag CoIP
20802461
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium
Cecum Lymphoma

Cecal Lymphoma
Placenta Praevia

Placenta Previa

Haemorrhage From Placenta Previa

Placenta Previa Haemorrhage

Lateral Placenta

Low Implantation Of Placenta Nos Or With Haemorrhage

Total Placenta Previa

Total Placenta Praevia Nos Or With Haemorrhage

Placental Previa Haemorrhage

Pp - [Placenta Previa]

Placenta Previa Marginalis

Placenta Previa Partialis

Partial Placenta Previa

Placenta Previa Centralis

Low Implantation Of Placenta

Low Implantation Or Insertion Of Placenta

Low Insertion Of Placenta

Low Lying Placenta

Marginal Placenta

Marginal Placenta Praevia Nos Or With Haemorrhage

Marginal Placenta Previa

Marginal Placental Haemorrhage

Partial Placenta Praevia Nos Or With Haemorrhage
Retinal Degeneration

Degeneration Of Retina
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson
Whim Syndrome 1

Whim Syndrome

Whims

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

WHIMS1

Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

Myelokathexis, Isolated

Wilm

Warts-Infections-Leukopenia-Myelokatexis Syndrome

Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Opioid Abuse

Opioid-Related Disorders
Pain Agnosia

Analgesia
Nephrogenic Syndrome Of Inappropriate Antidiuresis

NSIAD
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Morphine Dependence
Marfan Syndrome

MFS

Mfs1

Marfan'S Syndrome

Marfan Syndrome Type 1

Marfan Syndrome, Type I

Mass Phenotype

Contractural Arachnodactyly

Mass Syndrome

Octd

Overlap Connective Tissue Disease

Marfanoid Hypermobility Syndrome

Marfan Disease
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Constipation
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01029 ARRB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ARRB2 VGNC VGNC:70022
Canis familiaris ARRB2 VGNC VGNC:38137
Bos taurus ARRB2 VGNC VGNC:26170
Felis catus ARRB2 VGNC VGNC:97355
Mus musculus ARRB2 MGD MGI:99474
Rattus norvegicus ARRB2 RGD RGD:2157
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