2. Gene
  3. PPM1B - protein phosphatase, Mg2+/Mn2+ dependent 1B Gene

PPM1B - protein phosphatase, Mg2+/Mn2+ dependent 1B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶，Mg2+/Mn2+ 依赖性 1B

种属: Homo sapiens

同用名: PP2CB; PP2CBETA; PP2C-beta; PPC2BETAX; PP2C-beta-X

基因 ID: 5495 | 基因类型: protein coding

关于 PPM1B

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:44,168,875-44,246,928 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues, 16 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 9.6), brain (RPKM 8.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是 Ser/Thr 蛋白磷酸酶 PP2C 家族的成员。已知 PP2C 家族成员是细胞应激反应途径的负调节剂。这种磷酸酶已被证明可以使细胞周期蛋白依赖性激酶 (CDK) 去磷酸化，因此可能参与细胞周期控制。据报道，这种磷酸酶的过度表达会导致细胞生长停滞或细胞死亡。可变剪接导致编码不同异构体的多个转录变体。已经描述了其他转录变体，但目前不代表全长序列。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this Phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

PPM1B 基因产物(4)

mRNA Protein Name
NM_001033557.3 NP_001028729.1 protein phosphatase 1B isoform 5
NM_002706.6 NP_002697.1 protein phosphatase 1B isoform 1
NM_177968.4 NP_808907.1 protein phosphatase 1B isoform 2
NM_177969.4 NP_808908.1 protein phosphatase 1B isoform 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16872604 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
20801214 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
18930133 GOA
involved in negative regulation of defense response to virus IMP
IMP: 通过突变表型推断
22750291 GOA
involved in negative regulation of interferon-beta production IMP
IMP: 通过突变表型推断
22750291 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
18930133 GOA
involved in peptidyl-threonine dephosphorylation IDA
IDA: 通过直接分析推断
20801214 GOA
involved in protein dephosphorylation IMP
IMP: 通过突变表型推断
18930133 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPM1B 蛋白结构

PP2C

PP2C: Protein phosphatase 2C (23 - 288)

PP2C_C

PP2C_C: Protein serine/threonine phosphatase 2C, C-terminal domain (289 - 369)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
蛋白主名 其他名称

protein phosphatase 1B

protein phosphatase 2C-like protein

关联疾病

疾病名称 别名
Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease

2p21 Microdeletion Syndrome

HCS

Homozygous 2p16 Deletion Syndrome, Formerly

2p21 Deletion Syndrome

Del(2)(P21)

Monosomy 2p21

Atypical Hypotonia-Cystinuria Syndrome

Atypical Hcs
Cystinuria

CSNU

Cystinuria Type B

Cystinuria Type A

Cystinuria, Type I, Formerly

Csnu1, Formerly

Cystinuria, Type Ii, Formerly

Cystinuria, Type Iii, Formerly

Csnu3, Formerly

Cystinuria, Type Non-I, Formerly

Cystinuria-Lysinuria

Cystinuria-Lysinuria Syndrome

Csnu1

Csnu3

Cystinuria 1

Cystinuria Type A/B

Cystinuria Type I

Cystinuria Type Ii

Cystinuria Type Iii

Cystinuria Type Non-I

Cystinuria, Type A/B

Cystinuria Type 1

Cystinuria - Lysinuria

Csnu - [Cystinuria]

Cystine Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-159521 HN252 98.54% 否
HY-RS10961 PPM1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PPM1B VGNC VGNC:68993
Bos taurus PPM1B VGNC VGNC:33209
Mus musculus PPM1B MGD MGI:101841
Macaca mulatta PPM1B VGNC VGNC:76241
Rattus norvegicus PPM1B RGD RGD:3374
Canis familiaris PPM1B VGNC VGNC:44863
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