2. Gene
  3. NOLC1 - nucleolar and coiled-body phosphoprotein 1 Gene

NOLC1 - nucleolar and coiled-body phosphoprotein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核仁和卷曲体磷蛋白 1

种属: Homo sapiens

同用名: P130; Srp40; NOPP130; NOPP140; NS5ATP13

基因 ID: 9221 | 基因类型: protein coding

关于 NOLC1

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,152,389-102,163,870 (from NCBI)

This gene has 9 transcripts (splice variants) and 171 orthologues. Ubiquitous expression in brain (RPKM 23.0), thyroid (RPKM 22.8) and 25 other tissues.

功能概要

启用蛋白质异二聚化活性和蛋白质-大分子接头活性。参与神经嵴细胞发育；神经嵴形成；和翻译规则。位于纤维中心。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein heterodimerization activity and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]

NOLC1 基因产物(3)

mRNA Protein Name
NM_001284388.2 NP_001271317.1 nucleolar and coiled-body phosphoprotein 1 isoform 1
NM_001284389.2 NP_001271318.1 nucleolar and coiled-body phosphoprotein 1 isoform 3
NM_004741.5 NP_004732.2 nucleolar and coiled-body phosphoprotein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular function inhibitor activity EXP
EXP: 通过实验结果推断
22906532 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17620599 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
26399832 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
26399832 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in neural crest cell development IMP
IMP: 通过突变表型推断
26399832 GOA
involved in neural crest formation IMP
IMP: 通过突变表型推断
26399832 GOA
involved in regulation of translation IMP
IMP: 通过突变表型推断
26399832 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOLC1 蛋白结构

SRP40_C

SRP40_C: SRP40, C-terminal domain (624 - 696)

  • 0
  • 200
  • 400
  • 600
  • 699 a.a.
蛋白主名 其他名称

nucleolar and coiled-body phosphoprotein 1

140 kDa nucleolar phosphoprotein

NOLC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NOLC1 Q14978 ARRB2 Homo sapiens P32121
Anti Tag CoIP
17620599
Intra NOLC1 Q14978 ARRB1 Homo sapiens P49407
Anti Tag CoIP
17620599
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Treacher Collins Syndrome 1

Treacher Collins Syndrome

Mandibulofacial Dysostosis

Treacher Collins-Franceschetti Syndrome

Tcof

Tcs

Mfd1

Franceschetti-Klein Syndrome

TCS1

Franceschetti Syndrome

Franceschetti-Zwahlen-Klein Syndrome

Zygoauromandibular Dysplasia

Treacher-Collins Syndrome

Mandibulofacial Dysostosis Without Limb Anomalies

Bilateral And Symmetric Oto-Mandibular Dysplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09420 NOLC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NOLC1 VGNC VGNC:43885
Macaca mulatta NOLC1 VGNC VGNC:75178
Bos taurus NOLC1 VGNC VGNC:32161
Mus musculus NOLC1 MGD MGI:1918019
Rattus norvegicus NOLC1 RGD RGD:621578
Felis catus NOLC1 VGNC VGNC:63854
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