2. Gene
  3. PDE4D - phosphodiesterase 4D Gene

PDE4D - phosphodiesterase 4D Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 4D

种属: Homo sapiens

同用名: DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2

基因 ID: 5144 | 基因类型: protein coding

关于 PDE4D

Cytogenetic location: 5q11.2-q12.1 Genomic coordinates (GRCh38): 5:58,969,038-60,522,128 (from NCBI)

This gene has 28 transcripts (splice variants), 243 orthologues, 20 paralogues and is associated with 5 phenotypes. Broad expression in bone marrow (RPKM 7.8), lung (RPKM 3.1) and 20 other tissues.

功能概要

该基因编码果蝇“dunce”基因的四个哺乳动物对应物之一。编码的蛋白质具有 3',5'-cyclic-AMP 磷酸二酯酶活性并降解 cAMP，cAMP 在多种细胞类型中充当信号转导分子。该基因使用不同的启动子来生成多个可变剪接的转录变体，这些变体编码功能性蛋白质。[RefSeq 提供，2009 年 9 月]

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

PDE4D 基因产物(18)

mRNA Protein Name
NM_001104631.2 NP_001098101.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D4
NM_001165899.2 NP_001159371.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7
NM_001197218.2 NP_001184147.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D5
NM_001197219.2 NP_001184148.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D8
NM_001197220.2 NP_001184149.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D9
NM_001197221.2 NP_001184150.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D2
NM_001197222.2 NP_001184151.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D1
NM_001197223.2 NP_001184152.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D6
NM_001349241.2 NP_001336170.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 10
NM_001349242.2 NP_001336171.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 11
NM_001349243.2 NP_001336172.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 12
NM_001364599.1 NP_001351528.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7
NM_001364600.2 NP_001351529.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 14
NM_001364601.1 NP_001351530.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 15
NM_001364602.2 NP_001351531.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 16
NM_001364603.1 NP_001351532.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D2
NM_001364604.1 NP_001351533.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 12
NM_006203.5 NP_006194.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
9371713 GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
IGI: 通过遗传相互作用推断
8413254 GOA
enables ATPase binding IPI
IPI: 通过物理相互作用推断
21903937 GOA
enables cAMP binding IDA
IDA: 通过直接分析推断
9371713 GOA
enables heterocyclic compound binding IPI
IPI: 通过物理相互作用推断
9371713 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17620599 GOA
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
15182229 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
16213210 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
17404263 GOA
involved in cellular response to cAMP IDA
IDA: 通过直接分析推断
12121997 GOA
involved in cellular response to epinephrine stimulus IDA
IDA: 通过直接分析推断
12121997 GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
20819076 GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
19252089 GOA
involved in positive regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
17404263 GOA
involved in positive regulation of interleukin-5 production IMP
IMP: 通过突变表型推断
17404263 GOA
involved in positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
17404263 GOA
involved in regulation of cell communication by electrical coupling involved in cardiac conduction IMP
IMP: 通过突变表型推断
16213210 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcium channel complex IDA
IDA: 通过直接分析推断
16213210 GOA
located in cytosol IDA
IDA: 通过直接分析推断
9371713 GOA
NOT located in membrane IDA
IDA: 通过直接分析推断
9371713 GOA
located in membrane IDA
IDA: 通过直接分析推断
9371713 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDE4D 蛋白结构

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (461 - 705)

  • 0
  • 200
  • 400
  • 600
  • 809 a.a.
蛋白主名 其他名称

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

cAMP-specific phosphodiesterase PDE4D6

PDE4D 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PDE4D Q08499 GOLGA8F Homo sapiens Q08AF8
Y2H Array
25416956
Intra PDE4D Q08499 GOLGA8DP Homo sapiens Q0D2H9
Y2H Array
25416956
Intra PDE4D Q08499 GOLGA8DP Homo sapiens Q0D2H9
Y2H Prey Pooling
25416956
Intra PDE4D Q08499 GOLGA8DP Homo sapiens Q0D2H9
Validated Y2H
25416956
Intra PDE4D Q08499 MAGEA6 Homo sapiens P43360
Validated Y2H
25416956
Intra PDE4D Q08499 PDE4B Homo sapiens Q07343
Anti Tag CoIP
33961781
Intra PDE4D Q08499 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra PDE4D Q08499 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra PDE4D Q08499 COIL Homo sapiens P38432
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acrodysostosis 2 With Or Without Hormone Resistance

ACRDYS2

Acrodysostosis 2, With Or Without Hormone Resistance

Acrodysostosis, With/Without Hormone Resistance, Type 2

Acrodysostosis
Acrodysostosis With Multiple Hormone Resistance
Acrodysostosis

Acrodysplasia

Arkless-Graham Syndrome

Maroteaux-Malamut Syndrome

Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome

Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Chromosome 5q12 Deletion Syndrome

Pde4d Haploinsufficiency Syndrome
Pseudohypoparathyroidism

Familial Pseudohypoparathyroidism

Parathyroid Hormone Resistant Hypoparathyroidism

Php - [Pseudohypoparathyroidism]

Constitutional Chronic Hypocalcaemia
Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident
Ocular Hypotension

Hypotony Of Eye
Spinal Stenosis

Lumbar Spinal Stenosis

Cervical Spinal Stenosis

Spinal Stenosis Of Lumbar Region

Spinal Stenosis In Cervical Region

Spinal Canal Stenosis
Brachydactyly
Hypertension And Brachydactyly Syndrome

Brachydactyly With Hypertension

Bilginturan Syndrome

HTNB

Brachydactyly-Arterial Hypertension Syndrome

Brachydactyly, Type E, With Short Stature And Hypertension

Bilginturan Brachydactyly

Brachydactyly Type E With Short Stature And Hypertension

Type E Brachydactyly With Short Stature And Hypertension

Brachydactyly Type E, With Short Stature And Hypertension

Hypertension With Brachydactyly
Hypothyroidism, Congenital, Nongoitrous, 1

Tsh Resistance

CHNG1

Hypothyroidism Due To Tsh Receptor Mutations

Thyrotropin Resistance

Thyroid-Stimulating Hormone

Rtsh

Hypothyroidism Due To Unresponsiveness To Thyrotropin

Congenital Nongoitrous Hypothyroidism 1

Thyroid-Stimulating Hormone, Resistance To

Hypothyroidism, Nonautoimmune

Hypothyroidism, Congenital, Due To Tsh Resistance

Hypothyroidism, Congenital, Non-Goitrous, 1

Congenital Hypothyroidism Due To Tsh Resistance

Non-Autoimmune Hypothyroidism

Thyroid-Stimulating Hormone Resistance

Hypothyroidism, Congenital, Nongoitrous, Type 1

Hypothyroidism, Congenital, Nongoitrous, 3

Thyroid Hormone Resistance Syndrome
Pseudohypoparathyroidism, Type Ia

Albright'S Hereditary Osteodystrophy

Albright Hereditary Osteodystrophy

Pseudohypoparathyroidism Type 1a

PHP1A

Albright Hereditary Osteodystrophy With Multiple Hormone Resistance

Pseudohypoparathyroidism Ia

AHO

Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy

Pseudo-Pseudohypoparathyroidism

Pseudohypoparathyroidism Type I A

Php Ia

Pseudopseudohypoparathyroidism

Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance

Pphp

Pseudopseudo-Hypoparathyroidism

Aho-Php Syndrome Ia

Albright Hereditary Osteodystrophy-Php Syndrome Ia

Pseudohypoparathyroidism 1a

Pseudohypoparathyroidism
Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event
Pseudopseudohypoparathyroidism

PPHP

Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance

Normocalcemic Pseudohypoparathyroidism

Aho-Pphp Syndrome

Albright Hereditary Osteodystrophy-Pphp Syndrome

Pseudohypoparathyroidism
Chondrodysplasia, Blomstrand Type

Chondrodysplasia Blomstrand Type

BOCD

Blomstrand Lethal Chondrodysplasia

Blomstrand Lethal Osteochondrodysplasia

Blomstrand'S Lethal Chondrodysplasia

Blc

Blomstrand Chondrodysplasia

Blomstrand Osteochondrodysplasia
Osseous Heteroplasia, Progressive

Progressive Osseous Heteroplasia

POH

Osteoma Cutis

Familial Ectopic Ossification

Ectopic Ossification Familial Type

Ectopic Ossification

Heterotopic Ossification

Ectopic Ossification, Familial

Cutaneous Ossification

Myositis Ossificans Progressiva

Osteodermia

Osteosis Cutis

Ossification Heterotopic

Heteroplasia, Osseous, Progressive

Fibrodysplasia Ossificans Progressiva
Chromosome 2q37 Deletion Syndrome

Albright Hereditary Osteodystrophy-Like Syndrome

2q37 Microdeletion Syndrome

Brachydactyly-Intellectual Disability Syndrome

Deletion 2q37

2q37 Deletion Syndrome

Brachydactyly-Mental Retardation Syndrome

Bdmr

Albright Hereditary Osteodystrophy Type 3

Del(2)(Q37)

Monosomy 2q37qter

Albright'S Hereditary Osteodystrophy-Like Syndrome

Monosomy 2q37

Chromosome Deletion Syndrome 2q37
Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease

COPD

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Chronic Obstructive Lung Disease

Chronic Obstructive Airway Disease

Pulmonary Disease, Chronic Obstructive, Susceptibility To

Cold

Severe Early-Onset Chronic Obstructive Pulmonary Disease

Pulmonary Disease Chronic Obstructive

Pulmonary Disease, Obstructive, Chronic, Susceptibility To

Chronic Obstructive Pulmonary Disease Of Horses

Common Cold

Upper Respiratory Infections

Copd - [Chronic Obstructive Pulmonary Disease]

Coad - [Chronic Obstructive Airways Disease]

Cold - [Chronic Obstructive Lung Disease]

Chronic Airway Disease Nos

Chronic Airways Limitation, Unspecified

Chronic Obstructed Airway, Unspecified

Chronic Obstructive Airway Disease, Unspecified

Chronic Obstructive Airway, Unspecified

Obstructive Lung Disease Nos

Chronic Obstructive Lung Disease Nos

Chronic Obstructive Lung Nos

Obstructive Pulmonary Disease Nos

Exacerbation Copd Nos

Acute Exacerbation Copd
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Pseudohypoparathyroidism, Type Ib

Pseudohypoparathyroidism Type 1b

PHP1B

Pseudohypoparathyroidism Ib

Pseudohypoparathyroidism Type Ib

Php Ib

Pseudohypoparathyroidism 1b
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-117571 Zatolmilast Inhibitor 98.98% Phase 3
HY-16900 Rolipram Inhibitor 99.47% Phase 2
HY-117960 Orismilast Inhibitor 99.37% Phase 2
HY-15178 Oglemilast Inhibitor 98.00% Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1
Pre-clinical Phase
生物活性分子 (29)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128358 MR-L2 Activator 99.23% 否
HY-122942 Moracin M 98.90% 否
HY-15444 D159687 Inhibitor 98.34% 否
HY-115687 PDE4B-IN-2 Inhibitor 99.21% 否
HY-16900A (R)-(-)-Rolipram Inhibitor 99.89% 否
HY-119190 PF-06445974 Inhibitor 98.23% 否
HY-103050 ML-030 Inhibitor 99.50% 否
HY-131707 LEO 39652 Inhibitor 99.51% 否
HY-100246 CI-1044 Inhibitor 98.02% 否
HY-117977 FCPR03 Inhibitor 99.82% 否
HY-RS10225 PDE4D Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-131340 LASSBio-1632 Inhibitor / 否
HY-130262 PDE1-IN-3 Inhibitor / 否
HY-115913 PDE4-IN-6 Inhibitor / 否
HY-121037 Eggmanone Inhibitor / 否
HY-147846 AChE/PDE4-IN-1 Inhibitor / 否
HY-154957 mTOR inhibitor-11 Inhibitor / 否
HY-159654 PDE4-IN-19 Inhibitor / 否
HY-161772 (S)-Gebr32a Inhibitor / 否
HY-161936 Z21115 Inhibitor / 否
HY-162582 Z19153 Inhibitor / 否
HY-162583 PDE4-IN-17 Inhibitor / 否
HY-163604 PDE4B/D-IN-1 Inhibitor / 否
HY-163605 PDE4B/D-IN-2 Inhibitor / 否
HY-163606 PDE4B/D-IN-3 Inhibitor / 否
HY-168558 PDE4B/D-IN-4 Inhibitor / 否
HY-N3180 Norbraylin Inhibitor / 否
HY-119799 UK-500001 Inhibitor / 否
HY-112704 PDE5-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PDE4D VGNC VGNC:32677
Felis catus PDE4D VGNC VGNC:68759
Macaca mulatta PDE4D VGNC VGNC:75917
Canis familiaris PDE4D VGNC VGNC:44355
Rattus norvegicus PDE4D RGD RGD:3281
Mus musculus PDE4D MGD MGI:99555
Others PDE4D NCBI
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