2. Gene
  3. PDE4B - phosphodiesterase 4B Gene

PDE4B - phosphodiesterase 4B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 4B

种属: Homo sapiens

同用名: DPDE4; PDEIVB

基因 ID: 5142 | 基因类型: protein coding

关于 PDE4B

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:65,792,510-66,374,579 (from NCBI)

This gene has 18 transcripts (splice variants), 290 orthologues and 20 paralogues. Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues.

功能概要

该基因是 IV 型环磷酸二酯酶 (cAMP) 特异性环核苷酸磷酸二酯酶 (PDE) 家族的成员。编码的蛋白质调节环核苷酸的细胞浓度，从而在信号转导中发挥作用。这种蛋白质的活性改变与精神分裂症和双相情感障碍有关。可变剪接和替代启动子的使用导致编码不同亚型的多个转录变体。[RefSeq 提供，2014 年 7 月]

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

PDE4B 基因产物(7)

mRNA Protein Name
NM_001037339.2 NP_001032416.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2
NM_001037340.3 NP_001032417.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 3
NM_001037341.2 NP_001032418.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1
NM_001297440.2 NP_001284369.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 4
NM_001297441.1 NP_001284370.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 5
NM_001297442.2 NP_001284371.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 6
NM_002600.4 NP_002591.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
17404263 GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
IGI: 通过遗传相互作用推断
8413254 GOA
enables cAMP binding IGI
IGI: 通过遗传相互作用推断
8413254 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
33961781 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
17404263 GOA
involved in positive regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
17404263 GOA
involved in positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
17404263 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDE4B 蛋白结构

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (405 - 649)

  • 0
  • 200
  • 400
  • 600
  • 736 a.a.
蛋白主名 其他名称

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

dunce-like phosphodiesterase E4

PDE4B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDE4B Q07343 CACNA1C Homo sapiens Q13936
Anti Bait CoIP
37207277
种属间: 跨种属相互作用 种属内: 同种属相互作用

PDE4B 抗体

目录号 产品名 应用 反应物种
HY-P83187 PDE4B Antibody (YA2932) WB, FC Human, Mouse

关联疾病

疾病名称 别名
Ocular Hypotension

Hypotony Of Eye
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Brugada Syndrome 3

BRGDA3

Brugada Syndrome, Type 3
Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event
Severe Congenital Neutropenia 8

Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities

Scn8

Sdsl

Shwachman-Diamond Syndrome-Like
Acrodysostosis

Acrodysplasia

Arkless-Graham Syndrome

Maroteaux-Malamut Syndrome

Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome

Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-153192 Nerandomilast Inhibitor 99.93% Phase 3
HY-153192A Nerandomilast dihydrate Inhibitor 99.93% Phase 3
HY-16900 Rolipram Inhibitor 99.47% Phase 2
HY-10469 GSK256066 Inhibitor 98.15% Phase 2
HY-117960 Orismilast Inhibitor 99.37% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-70069 GSK256066 Trifluoroacetate Inhibitor 99.54% Phase 2
HY-144683 PF-07038124 Inhibitor / Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1
Pre-clinical Phase
生物活性分子 (27)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128358 MR-L2 Activator 99.23% 否
HY-122942 Moracin M 98.90% 否
HY-115687 PDE4B-IN-2 Inhibitor 99.21% 否
HY-16900A (R)-(-)-Rolipram Inhibitor 99.89% 否
HY-147830 PDE4B-IN-3 Inhibitor 99.40% 否
HY-119190 PF-06445974 Inhibitor 98.23% 否
HY-103050 ML-030 Inhibitor 99.50% 否
HY-100246 CI-1044 Inhibitor 98.02% 否
HY-131707 LEO 39652 Inhibitor 99.51% 否
HY-117977 FCPR03 Inhibitor 99.82% 否
HY-115913 PDE4-IN-6 Inhibitor / 否
HY-121162 Mesembrine Inhibitor / 否
HY-144683A PF-07038124 hydrochloride Inhibitor / 否
HY-144684 PDE4-IN-8 Inhibitor / 否
HY-146201 PDE4B/7A-IN-1 / 否
HY-146202 PDE4B/7A-IN-2 / 否
HY-147950 PDE4-IN-10 Inhibitor / 否
HY-159654 PDE4-IN-19 Inhibitor / 否
HY-161851 MDL3 Inhibitor / 否
HY-162582 Z19153 Inhibitor / 否
HY-162583 PDE4-IN-17 Inhibitor / 否
HY-163604 PDE4B/D-IN-1 Inhibitor / 否
HY-163605 PDE4B/D-IN-2 Inhibitor / 否
HY-163606 PDE4B/D-IN-3 Inhibitor / 否
HY-168558 PDE4B/D-IN-4 Inhibitor / 否
HY-RS10223 PDE4B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-119799 UK-500001 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PDE4B VGNC VGNC:75916
Rattus norvegicus PDE4B RGD RGD:3280
Bos taurus PDE4B VGNC VGNC:32676
Felis catus PDE4B VGNC VGNC:82496
Mus musculus PDE4B MGD MGI:99557
Canis familiaris PDE4B VGNC VGNC:44354
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