2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE4B-IN-2

PDE4B-IN-2 是一种具有口服活性，选择性 PDE4B 抑制剂，IC50 为 15 nM。PDE4B-IN-2 抑制 PDE4D (IC50=1.7 µM)。PDE4B-IN-2 表现出有效的抗炎作用。

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PDE4B-IN-2 Chemical Structure

PDE4B-IN-2 Chemical Structure

CAS No. : 915082-52-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥990
In-stock
1 mg ￥360
In-stock
5 mg ￥900
In-stock
10 mg ￥1400
In-stock
25 mg ￥2800
In-stock
50 mg ￥4500
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

PDE4B-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects[1].

IC50 & Target[1]

PDE4B

15 nM (IC50)

PDE4D

1.7 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf9 IC50
32 nM
Compound: 16; CHEMBL1782306
Inhibition of human N-terminal His6-tagged PDE4B1 catalytic domain (324 to 691 residues) expressed in baculovirus infected sf9 cells using cAMP as substrate preincubated for 15 mins followed by substrate addition measured for 10 mins in presence of NADH b
Inhibition of human N-terminal His6-tagged PDE4B1 catalytic domain (324 to 691 residues) expressed in baculovirus infected sf9 cells using cAMP as substrate preincubated for 15 mins followed by substrate addition measured for 10 mins in presence of NADH b
[PMID: 26908025]
体外研究
(In Vitro)

PDE4B-IN-2 (compound 33) does not inhibit CYP1A2, CYP3A4, CYP2C9, and CYP2D (IC50>10 µM)[1].
PDE4B-IN-2 inhibits LPS-induced TNF-aproduction in vitro from mouseperipheral blood mononuclear cell (PBMC; IC50=0.5 M)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PDE4B-IN-2 相关抗体:
体内研究
(In Vivo)

PDE4B-IN-2 (compound 33; 2 mg/kg; po) has a Cmax of 8.7 μg/mL and an AUC of 52.3 μg•h/mL in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

387.88

Formula

C19H18ClN3O2S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (64.45 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5781 mL 12.8906 mL 25.7812 mL
5 mM 0.5156 mL 2.5781 mL 5.1562 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

PDE4B-IN-2 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5781 mL 12.8906 mL 25.7812 mL 64.4529 mL
5 mM 0.5156 mL 2.5781 mL 5.1562 mL 12.8906 mL
10 mM 0.2578 mL 1.2891 mL 2.5781 mL 6.4453 mL
15 mM 0.1719 mL 0.8594 mL 1.7187 mL 4.2969 mL
20 mM 0.1289 mL 0.6445 mL 1.2891 mL 3.2226 mL
25 mM 0.1031 mL 0.5156 mL 1.0312 mL 2.5781 mL
30 mM 0.0859 mL 0.4297 mL 0.8594 mL 2.1484 mL
40 mM 0.0645 mL 0.3223 mL 0.6445 mL 1.6113 mL
50 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.2891 mL
60 mM 0.0430 mL 0.2148 mL 0.4297 mL 1.0742 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE4B-IN-2915082-52-9Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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