1. Gene
  2. PRPF4B - pre-mRNA processing factor 4B Gene

PRPF4B - pre-mRNA processing factor 4B Gene

中文名称:pre-mRNA 加工因子 4B

种属: Homo sapiens

同用名: PR4H; PRP4; PRP4H; PRP4K; dJ1013A10.1

基因 ID: 8899 | 基因类型: protein coding

关于 PRPF4B

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:4,021,300-4,064,983 (from NCBI)

This gene has 9 transcripts (splice variants), 240 orthologues and 26 paralogues. Ubiquitous expression in bone marrow (RPKM 15.0), lymph node (RPKM 13.5) and 25 other tissues.

功能概要

Pre-mRNA 剪接发生在两个连续的酯交换步骤中,并且该基因编码的蛋白质被认为参与了 pre-mRNA 剪接和信号转导。这种蛋白质属于激酶家族,包括富含丝氨酸/精氨酸的蛋白质特异性激酶和细胞周期蛋白依赖性激酶 (CDK) 。这种蛋白质被认为是一种 CDK 样激酶 (CLK) ,与丝裂原活化蛋白激酶 (MAPK) 具有同源性。[RefSeq 提供,2008 年 7 月]

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (CLK) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

PRPF4B 基因产物(1)

mRNA Protein Name
NM_003913.5 NP_003904.3 serine/threonine-protein kinase PRP4 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15452250 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10799319 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of hippo signaling IDA
IDA: 通过直接分析推断
29695716 GOA
involved in positive regulation of protein export from nucleus IDA
IDA: 通过直接分析推断
29695716 GOA
involved in regulation of mitotic cell cycle spindle assembly checkpoint IDA
IDA: 通过直接分析推断
17998396 GOA
involved in spliceosomal snRNP assembly IDA
IDA: 通过直接分析推断
12077342 GOA
involved in spliceosomal tri-snRNP complex assembly IDA
IDA: 通过直接分析推断
20118938 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
17998396 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
12077342 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
29695716 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20118938 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PRPF4B 蛋白结构

Pkinase

Pkinase: Protein kinase domain (691 - 1003)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1007 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PRP4 homolog

PRP4 kinase

PRPF4B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRP4K Q13523 KLF13 Homo sapiens Q9Y2Y9
Imaging
17513757
Intra PRP4K Q13523 KLF13 Homo sapiens Q9Y2Y9
Anti Bait CoIP
17513757
Intra PRP4K Q13523 KLF13 Homo sapiens Q9Y2Y9
Y2H
17513757
Cross PRP4K Q13523 gag Human immunodeficiency virus P04590
Protein Kinase Assay
15452250
Cross PRP4K Q13523 gag Human immunodeficiency virus P04590
Anti Tag CoIP
15452250
Cross PRP4K Q13523 gag Human immunodeficiency virus P04590
Pull Down
15452250
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Felis catus PRPF4B VGNC VGNC:64377
Canis familiaris PRPF4B VGNC VGNC:45028
Rattus norvegicus PRPF4B RGD RGD:1307784
Bos taurus PRPF4B VGNC VGNC:33381
Macaca mulatta PRPF4B VGNC VGNC:76276
Mus musculus PRPF4B MGD MGI:109584
Others PRPF4B NCBI