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  4. KHS101

KHS101 是一种加速神经元分化的小分子。KHS101 可分布到脑内，导致神经元分化显著增加。

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KHS101 Chemical Structure

KHS101 Chemical Structure

CAS No. : 1262770-73-9

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KHS101 的其他形式现货产品:

Customer Review

Other Forms of KHS101:

KHS101 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
JIMT-1 IC50
32.98 μM
Compound: 7a
Antiproliferative activity against human JIMT-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human JIMT-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 36332551]
MDA-MB-231 IC50
31.13 μM
Compound: 7a
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 36332551]
SK-OV-3 IC50
21.44 μM
Compound: 7a
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 36332551]
U-251 IC50
49.13 μM
Compound: 7a
Cytotoxicity against human U251 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Cytotoxicity against human U251 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 36332551]
U-87MG ATCC IC50
37.85 μM
Compound: 7a
Antiproliferative activity against human U87 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36332551]
体外研究
(In Vitro)

KHS101 诱导贴壁培养大鼠 NPCs 神经元分化呈剂量依赖性 (EC50 ~ 1 μM)[1]。
KHS101 (5 μM) 抑制 NPCs 星形胶质细胞形成[1]。< br / > KHS101 (5 μM; 24-72 h) 对 NPCs 细胞周期进程和增殖有负面影响[1]。
KHS101 与 TACC3 蛋白特异性相互作用[1]。
KHS101 (0-15 μM; 24 h) 调控转录因子 ARNT2 的核定位[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KHS101 相关抗体:

RT-PCR[1]

Cell Line: Rat NPCs
Concentration: 0.6, 1.7 and 5 μM
Incubation Time: 24 h
Result: Showed a dose-dependent induction of Cdkn1 mRNA expression.

Cell Proliferation Assay[1]

Cell Line: Rat NPCs
Concentration: 5 μM
Incubation Time: 24, 48 and 72 h
Result: The vast majority of NPCs stop proliferating within 72 h, become mitotically inactive.
体内研究
(In Vivo)

KHS101 (6 mg/kg; s.c.; BID for 14 days) 在体内分布于大鼠脑内，显著促进神经元分化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Fisher 344 rats (∼10 wk old)[1]
Dosage: 6 mg/kg
Administration: SC, BID for 14 days
Result: Increased neuronal differentiation. Reduced proliferation of NPCs.
分子量

339.46

Formula

C18H21N5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KHS101 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KHS1011262770-73-9KHS 101KHS-101OthersNPCsastrocyteTACC3ARNT2Inhibitorinhibitorinhibit

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产品名称：
KHS101
目录号：
HY-10996
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