CKAP5 - cytoskeleton associated protein 5 Gene

中文名称：细胞骨架相关蛋白 5

种属: Homo sapiens

同用名: TOG; MSPS; TOGp; CHTOG; ch-TOG

关于 CKAP5

功能概要

该基因编码属于 TOG/XMAP215 家族的细胞骨架相关蛋白。该蛋白质的 N 端一半包含微管结合域，C 端一半包含用于结合微管蛋白二聚体的 KXGS 基序。这种蛋白质在纺锤体形成中有两个不同的作用；它保护着丝粒微管免于解聚，并在中心体微管组装中发挥重要作用。这种蛋白质可能是微管与细胞皮层正确相互作用以进行定向细胞运动所必需的。它还通过与与 MBP 相关的异质核核糖核蛋白 (hnRNP) A2 相互作用，在髓鞘碱性蛋白 (MBP) mRNA 的翻译中发挥作用。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]