TACC1 - transforming acidic coiled-coil containing protein 1 Gene

中文名称：含转化酸性卷曲螺旋 1

种属: Homo sapiens

同用名: Ga55

基因 ID: 6867 | 基因类型: protein coding

关于 TACC1

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:38,728,582-38,853,028 (from NCBI)

This gene has 29 transcripts (splice variants), 264 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 59.1), endometrium (RPKM 38.3) and 24 other tissues.

功能概要

该基因座可能代表乳腺癌候选基因。它位于 8 号染色体区域的 FGFR1 附近，该区域在某些乳腺癌中被扩增。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2017 年 6 月]

This locus may represent a breast Cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

TACC1 基因产物(31)

mRNA	Protein	Name
NM_001122824.2	NP_001116296.1	transforming acidic coiled-coil-containing protein 1 isoform 2
NM_001146216.3	NP_001139688.1	transforming acidic coiled-coil-containing protein 1 isoform 3
NM_001330521.2	NP_001317450.1	transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352778.2	NP_001339707.1	transforming acidic coiled-coil-containing protein 1 isoform 5
NM_001352779.2	NP_001339708.1	transforming acidic coiled-coil-containing protein 1 isoform 6
NM_001352780.2	NP_001339709.1	transforming acidic coiled-coil-containing protein 1 isoform 7
NM_001352781.2	NP_001339710.1	transforming acidic coiled-coil-containing protein 1 isoform 8
NM_001352782.2	NP_001339711.1	transforming acidic coiled-coil-containing protein 1 isoform 9
NM_001352783.2	NP_001339712.1	transforming acidic coiled-coil-containing protein 1 isoform 10
NM_001352784.2	NP_001339713.1	transforming acidic coiled-coil-containing protein 1 isoform 11
NM_001352785.2	NP_001339714.1	transforming acidic coiled-coil-containing protein 1 isoform 12
NM_001352786.2	NP_001339715.1	transforming acidic coiled-coil-containing protein 1 isoform 13
NM_001352787.2	NP_001339716.1	transforming acidic coiled-coil-containing protein 1 isoform 14
NM_001352788.2	NP_001339717.1	transforming acidic coiled-coil-containing protein 1 isoform 15
NM_001352789.2	NP_001339718.1	transforming acidic coiled-coil-containing protein 1 isoform 3
NM_001352790.2	NP_001339719.1	transforming acidic coiled-coil-containing protein 1 isoform 3
NM_001352791.1	NP_001339720.1	transforming acidic coiled-coil-containing protein 1 isoform 3
NM_001352792.2	NP_001339721.1	transforming acidic coiled-coil-containing protein 1 isoform 16
NM_001352793.2	NP_001339722.1	transforming acidic coiled-coil-containing protein 1 isoform 17
NM_001352794.2	NP_001339723.1	transforming acidic coiled-coil-containing protein 1 isoform 17
NM_001352795.2	NP_001339724.1	transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352796.2	NP_001339725.1	transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352797.2	NP_001339726.1	transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352798.1	NP_001339727.1	transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352799.2	NP_001339728.1	transforming acidic coiled-coil-containing protein 1 isoform 18
NM_001352800.2	NP_001339729.1	transforming acidic coiled-coil-containing protein 1 isoform 19
NM_001352801.2	NP_001339730.1	transforming acidic coiled-coil-containing protein 1 isoform 20
NM_001352802.1	NP_001339731.1	transforming acidic coiled-coil-containing protein 1 isoform 21
NM_001352803.2	NP_001339732.1	transforming acidic coiled-coil-containing protein 1 isoform 22
NM_001352804.2	NP_001339733.1	transforming acidic coiled-coil-containing protein 1 isoform 23
NM_006283.3	NP_006274.2	transforming acidic coiled-coil-containing protein 1 isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables nuclear estrogen receptor binding	IDA IDA: 通过直接分析推断	20078863	GOA
enables nuclear glucocorticoid receptor binding	IDA IDA: 通过直接分析推断	20078863	GOA
enables nuclear receptor binding	IDA IDA: 通过直接分析推断	20078863	GOA
enables nuclear receptor coactivator activity	IMP IMP: 通过突变表型推断	20078863	GOA
enables nuclear retinoic acid receptor binding	IDA IDA: 通过直接分析推断	20078863	GOA
enables nuclear retinoid X receptor binding	IDA IDA: 通过直接分析推断	20078863	GOA
enables nuclear thyroid hormone receptor binding	IDA IDA: 通过直接分析推断	20078863	GOA
enables peroxisome proliferator activated receptor binding	IDA IDA: 通过直接分析推断	20078863	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11903063	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TACC1 蛋白结构

TACC

0
200
400
600
805 a.a.

蛋白主名

其他名称

transforming acidic coiled-coil-containing protein 1

gastric cancer antigen Ga55

TACC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TACC1	O75410	MEMO1	Homo sapiens	Q9Y316	Y2H Prey Pooling	25416956
种属内	TACC1	O75410	MEMO1	Homo sapiens	Q9Y316	Y2H Array	25416956
种属内	TACC1	O75410	THAP12	Homo sapiens	O43422	Y2H Array	25416956
种属内	TACC1	O75410	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	33961781
种属内	TACC1	O75410	BTRC	Homo sapiens	Q9Y297	Y2H Array	31515488
种属内	TACC1	O75410	CKAP5	Homo sapiens	Q14008	Y2H	11903063
种属内	TACC1	O75410	CKAP5	Homo sapiens	Q14008	Anti Tag CoIP	14603251
种属内	TACC1	O75410	YEATS4	Homo sapiens	O95619	IF	11903063
种属内	TACC1	O75410	YEATS4	Homo sapiens	O95619	Y2H	11903063
种属内	TACC1	O75410	TDRD7	Homo sapiens	Q8NHU6	Anti Bait CoIP	14603251
种属内	TACC1	O75410	TDRD7	Homo sapiens	Q8NHU6	Pull Down	14603251
种属内	TACC1	O75410	TDRD7	Homo sapiens	Q8NHU6	Y2H	14603251
种属内	TACC1	O75410	STX5	Homo sapiens	Q13190	Y2H Prey Pooling	25416956
种属内	TACC1	O75410	STX5	Homo sapiens	Q13190	Validated Y2H	25416956
种属内	TACC1	O75410	SH2D4A	Homo sapiens	Q9H788	Y2H Array	25416956
种属内	TACC1	O75410	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	25416956
种属内	TACC1	O75410	SH2D4A	Homo sapiens	Q9H788	Y2H Array	31515488
种属内	TACC1	O75410	SH2D4A	Homo sapiens	Q9H788	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Giant Cell Glioblastoma

Monstrocellular Sarcoma

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Neurofibrosarcoma

Neurosarcoma

Malignant Peripheral Nerve Sheath Tumor

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Dysembryoplastic Neuroepithelial Tumor

Dysembryoplastic Neuroepithelial Tumour	Dysembryoplastic Neuroepithelial Neoplasm
Dnet

Cerebellar Astrocytoma

Astrocytoma Of Cerebellum

Pilocytic Astrocytoma Of Cerebellum

Cerebellar Pilocytic Astrocytoma

Pilomyxoid Astrocytoma

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14139	TACC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TACC1	RGD	RGD:1303120
Felis catus	TACC1	VGNC	VGNC:65918
Bos taurus	TACC1	VGNC	VGNC:35557
Canis familiaris	TACC1	VGNC	VGNC:47063
Mus musculus	TACC1	MGD	MGI:2443510
Macaca mulatta	TACC1	VGNC	VGNC:78080

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TACC1 - transforming acidic coiled-coil containing protein 1 Gene

关于 TACC1

功能概要

TACC1 基因产物(31)

TACC1 蛋白结构

TACC1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

TACC1 - transforming acidic coiled-coil containing protein 1 Gene

关于 TACC1

功能概要

TACC1 基因产物(31)

TACC1 蛋白结构

TACC1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z