1. Gene
  2. YEATS4 - YEATS domain containing 4 Gene

YEATS4 - YEATS domain containing 4 Gene

中文名称:含 YEATS 域 4

种属: Homo sapiens

同用名: YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik

基因 ID: 8089 | 基因类型: protein coding

关于 YEATS4

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,359,743-69,462,793 (from NCBI)

This gene has 5 transcripts (splice variants) and 207 orthologues. Broad expression in testis (RPKM 7.3), bone marrow (RPKM 4.6) and 25 other tissues.

功能概要

由该基因编码的蛋白质存在于核仁中。它与人 MLLT1 以及酵母和人 MLLT3 蛋白具有高度序列同源性。 MLLT1 和 MLLT3 蛋白都属于一类转录因子,表明编码的蛋白也可能代表转录因子。这种蛋白质被认为是 RNA 转录所必需的。该基因已被证明在肿瘤中被扩增。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2014 年 7 月]

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

YEATS4 基因产物(2)

mRNA Protein Name
NM_001300950.2 NP_001287879.1 YEATS domain-containing protein 4 isoform 2
NM_006530.4 NP_006521.1 YEATS domain-containing protein 4 isoform 1

YEATS4 蛋白结构

YEATS

YEATS: YEATS family (44 - 124)

  • 0
  • 100
  • 200
  • 227 a.a.
蛋白主名 其他名称

YEATS domain-containing protein 4

NuMA binding protein 1

YEATS4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
YEATS4 O95619 TPM1 Homo sapiens P09493-10 32296183
种属内
YEATS4 O95619 ANKK1 Homo sapiens Q8NFD2 32296183
种属内
YEATS4 O95619 TACC1 Homo sapiens O75410
Y2H
11903063
种属内
YEATS4 O95619 TACC1 Homo sapiens O75410 11903063
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Glioma
Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor

Atypical Lipoma

Alt

Wdls

Liposarcoma, Well Differentiated

Pleomorphic Lipoma

Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy

Patterned Macular Dystrophy 3

MDPT3

Mcrpe

Pleomorphic Liposarcoma

Pls

Liposarcoma Pleomorphic

Liposarcoma, Pleomorphic

Cellular Myxoid Liposarcoma

Round Cell Liposarcoma

Dedifferentiated Liposarcoma

Ddls

Liposarcoma Dedifferentiated

Liposarcoma, Dedifferentiated

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus YEATS4 MGD MGI:1927224
Felis catus YEATS4 VGNC VGNC:67135
Canis familiaris YEATS4 VGNC VGNC:48483
Rattus norvegicus YEATS4 RGD RGD:1305741
Bos taurus YEATS4 VGNC VGNC:37021