2. Gene
  3. ANKK1 - ankyrin repeat and kinase domain containing 1 Gene

ANKK1 - ankyrin repeat and kinase domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锚蛋白重复序列和激酶结构域 1

种属: Homo sapiens

同用名: PKK2; sgK288

基因 ID: 255239 | 基因类型: protein coding

关于 ANKK1

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,387,779-113,400,416 (from NCBI)

This gene has 2 transcripts (splice variants), 155 orthologues and 1 paralogue. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白属于 Ser/Thr 蛋白激酶家族，参与信号转导通路的蛋白激酶超家族。该基因与 chr 11 上的 DRD2 基因 (GeneID:1813) 密切相关，经过充分研究的限制性片段长度多态性 (RFLP) 命名为 TaqIA，最初与 DRD2 基因相关，但后来确定位于外显子 8 ANKK1 基因 (PMID：18621654、15146457) ，它会导致非保守氨基酸取代。目前尚不清楚该基因是否在先前与 Taq1A RFLP 相关的神经精神疾病中发挥作用。[RefSeq 提供，2009 年 9 月]

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]

ANKK1 基因产物(1)

mRNA Protein Name
NM_178510.2 NP_848605.1 ankyrin repeat and protein kinase domain-containing protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within regulation of cell cycle process IDA
IDA: 通过直接分析推断
27166167 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
27166167 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANKK1 蛋白结构

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (28 - 282)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (363 - 425)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (427 - 489)

Ank

Ank: Ankyrin repeat (494 - 523)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (531 - 619)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (626 - 689)

Ank

Ank: Ankyrin repeat (692 - 722)

  • 0
  • 200
  • 400
  • 600
  • 765 a.a.
蛋白主名 其他名称

ankyrin repeat and protein kinase domain-containing protein 1

X-kinase

ANKK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ANKK1 Q8NFD2 C12orf57 Homo sapiens Q99622
Validated Y2H
32296183
种属内
ANKK1 Q8NFD2 C12orf57 Homo sapiens Q99622
Y2H Prey Pooling
32296183
种属内
ANKK1 Q8NFD2 C12orf57 Homo sapiens Q99622
Y2H Array
32296183
种属内
ANKK1 Q8NFD2 YEATS4 Homo sapiens O95619
Y2H Array
32296183
种属内
ANKK1 Q8NFD2 YEATS4 Homo sapiens O95619
Pull Down
32707033
种属内
ANKK1 Q8NFD2 YEATS4 Homo sapiens O95619
Y2H Prey Pooling
32296183
种属内
ANKK1 Q8NFD2 CHN2 Homo sapiens P52757
Y2H Prey Pooling
32296183
种属内
ANKK1 Q8NFD2 CHN2 Homo sapiens P52757
Y2H Array
32296183
种属内
ANKK1 Q8NFD2 CHN1 Homo sapiens P15882
Y2H Prey Pooling
32296183
种属内
ANKK1 Q8NFD2 CHN1 Homo sapiens P15882
Y2H Array
32296183
种属内
ANKK1 Q8NFD2 HIF1AN Homo sapiens Q9NWT6
Anti Tag CoIP
33961781
种属内
ANKK1 Q8NFD2 HIF1AN Homo sapiens Q9NWT6
Validated Y2H
32296183
种属内
ANKK1 Q8NFD2 HIF1AN Homo sapiens Q9NWT6
Y2H Array
32296183
种属内
ANKK1 Q8NFD2 HIF1AN Homo sapiens Q9NWT6
Pull Down
32707033
种属内
ANKK1 Q8NFD2 HIF1AN Homo sapiens Q9NWT6
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Antisocial Personality Disorder

Dissocial Personality Disorder

Asocial Personality

Psychopath.Personality

Psychopathic Personality

Psychopathic Personality Disorder

Sociopathic Personality
Heroin Dependence
Drug Dependence
Pathological Gambling

Compulsive Gambling

Gambling

Gambling, Pathological

Addiction

Betting

Addiction

Gambling

Betting

Pathological

Gambling

Dependence
Neuroleptic Malignant Syndrome
Pyromania

Firesetting Behavior

Pathological Firesetting

Pathological Fire-Setting
Personality Disorder

Personality Disorders

Character Disorder

Personality

Specific Personality Disorders

Enduring Personality Change After Psychiatric Illness
Eating Disorder

Eating Disorders

Feeding And Eating Disorders
Kleptomania

Pathological Stealing
Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders
Alexithymia
Chromosome 17q23.1-Q23.2 Deletion Syndrome

17q23.1q23.2 Microdeletion Syndrome

17q23.1-Q23.2 Microdeletion Syndrome

Del(17)(Q23.1q23.2)

Monosomy 17q23.1q23.2

Monosomy 17q23.1-Q23.2
Opiate Dependence

Opioid Dependence

Opioid Addiction

Opiate Addiction

Opioid Type Dependence

Opioid-Related Disorders

Opium Dependence

Narcotic Dependence

Intravenous Narcotism

Narcotism Nos

Oral Narcotism Nos
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Substance Dependence
Premenstrual Tension

Premenstrual Syndrome

Pmt - [Premenstrual Tension]

Premenstrual Tension Nos

Syndrome Of Menstruation
Oppositional Defiant Disorder

Disorder

Oppositional Defiance

Behavioural Disorder

Oppositional Defiance

Disruptive Mood Dysregulation Disorder
Cannabis Dependence

Marijuana Abuse

Cannabinoid Addiction

Cannabinoid Dependence

Cannabis Addiction
Hallucinogen Dependence

Hallucinogen Addiction
Cocaine Dependence
Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome
Cannabis Abuse

Marijuana Abuse
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Substance Abuse

Substance-Related Disorders

Substance Abuse Problem
Alcohol Use Disorder

Alcohol Abuse

Alcoholism

Ethanol Abuse

Alcohol Addiction

Alcohol Dependence

Alcoholic Intoxication, Chronic

Alcohol-Related Disorders
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00708 ANKK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ANKK1 MGD MGI:3045301
Canis familiaris ANKK1 VGNC VGNC:37874
Rattus norvegicus ANKK1 RGD RGD:1305538
Bos taurus ANKK1 VGNC VGNC:54855
Felis catus ANKK1 VGNC VGNC:102736
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