2. Gene
  3. THAP12 - THAP domain containing 12 Gene

THAP12 - THAP domain containing 12 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 THAP 域 12

种属: Homo sapiens

同用名: DAP4; THAP0; PRKRIR; P52rIPK

基因 ID: 5612 | 基因类型: protein coding

关于 THAP12

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:76,349,956-76,381,132 (from NCBI)

This gene has 11 transcripts (splice variants), 295 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 20.3), thyroid (RPKM 16.8) and 25 other tissues.

功能概要

预测启用 DNA 结合活性；金属离子结合活性；和蛋白质二聚化活性。预计参与细胞群增殖和信号转导的负调控。预测位于核内。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA binding activity; metal ion binding activity; and protein dimerization activity. Predicted to be involved in negative regulation of cell population proliferation and signal transduction. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

THAP12 基因产物(1)

mRNA Protein Name
NM_004705.4 NP_004696.2 52 kDa repressor of the inhibitor of the protein kinase

THAP12 蛋白结构

THAP

THAP: THAP domain (4 - 88)

DUF4371

DUF4371: Domain of unknown function (DUF4371) (158 - 334)

Dimer_Tnp_hAT

Dimer_Tnp_hAT: hAT family C-terminal dimerisation region (636 - 728)

  • 0
  • 200
  • 400
  • 600
  • 761 a.a.
蛋白主名 其他名称

52 kDa repressor of the inhibitor of the protein kinase

58 kDa interferon-induced protein kinase-interacting protein

THAP12 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra THAP12 O43422 KIAA1958 Homo sapiens Q8N8K9
Y2H Array
32296183
Intra THAP12 O43422 KIAA1958 Homo sapiens Q8N8K9
Y2H Prey Pooling
32296183
Intra THAP12 O43422 KIAA1958 Homo sapiens Q8N8K9
Validated Y2H
32296183
Intra THAP12 O43422 ZNF526 Homo sapiens Q8TF50
Validated Y2H
32296183
Intra THAP12 O43422 ZNF526 Homo sapiens Q8TF50
Y2H Array
32296183
Intra THAP12 O43422 ZNF526 Homo sapiens Q8TF50
Y2H Prey Pooling
32296183
Intra THAP12 O43422 ZNF526 Homo sapiens Q8TF50
Anti Tag CoIP
33961781
Intra THAP12 O43422 TACC1 Homo sapiens O75410-7
Y2H Array
32296183
Intra THAP12 O43422 TACC1 Homo sapiens O75410-7
Y2H Prey Pooling
32296183
Intra THAP12 O43422 TACC1 Homo sapiens O75410-7
Validated Y2H
32296183
Intra THAP12 O43422 ZNF574 Homo sapiens Q6ZN55
Anti Tag CoIP
33961781
Intra THAP12 O43422 TACC1 Homo sapiens O75410
Y2H Prey Pooling
25416956
Intra THAP12 O43422 TACC1 Homo sapiens O75410
Validated Y2H
25416956
Intra THAP12 O43422 SELENBP1 Homo sapiens Q13228
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 58

RP58

Retinitis Pigmentosa, Type 58
Schimmelpenning-Feuerstein-Mims Syndrome

Nevus Sebaceus Of Jadassohn

Organoid Nevus Phakomatosis

Linear Nevus Sebaceous Syndrome

Sfm Syndrome

Jadassohn Nevus Phakomatosis

Jnp

Schimmelpenning Syndrome

Solomon Syndrome

SFM

Linear Sebaceous Nevus Syndrome

Schimmelpenning-Feuerstein-Mims Syndrome, Somatic Mosaic

Nevus Sebaceus Syndrome

Organoid Nevus Syndrome

Schimmelpenning Feuerstein Mims Syndrome

Sebaceous Nevus Syndrome, Linear

Epidermal Nevus Syndrome, Formerly

Sebaceous Nevus Syndrome Linear

Linear Nevus Sebaceus Syndrome

Epidermal Nevus Syndrome

Ss

Nevus Sebaceous
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14472 THAP12 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus THAP12 RGD RGD:1309679
Mus musculus THAP12 MGD MGI:1920231
Bos taurus THAP12 VGNC VGNC:35820
Felis catus THAP12 VGNC VGNC:81938
Macaca mulatta THAP12 VGNC VGNC:107650
Canis familiaris THAP12 VGNC VGNC:47326
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