2. Gene
  3. SELENBP1 - selenium binding protein 1 Gene

SELENBP1 - selenium binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：硒结合蛋白 1

种属: Homo sapiens

同用名: MTO; LPSB; SP56; hSBP; EHMTO; SBP56; HEL-S-134P

基因 ID: 8991 | 基因类型: protein coding

关于 SELENBP1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,364,304-151,372,705 (from NCBI)

This gene has 19 transcripts (splice variants), 269 orthologues and is associated with 2 phenotypes. Broad expression in colon (RPKM 232.0), lung (RPKM 124.7) and 17 other tissues.

功能概要

该基因编码硒结合蛋白家族的一个成员。硒是一种具有强大抗癌特性的必需营养素，硒缺乏可能会导致某些神经系统疾病。硒在预防癌症和神经系统疾病方面的作用可能是由硒结合蛋白介导的，并且该基因的表达减少可能与多种类型的癌症有关。编码的蛋白质可能在泛素化/去泛素化介导的蛋白质降解中发挥硒依赖性作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 4 月]

This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing Cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of Cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

SELENBP1 基因产物(3)

mRNA Protein Name
NM_001258288.2 NP_001245217.1 methanethiol oxidase isoform 2
NM_001258289.2 NP_001245218.1 methanethiol oxidase isoform 3
NM_003944.4 NP_003935.2 methanethiol oxidase isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methanethiol oxidase activity IMP
IMP: 通过突变表型推断
29255262 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SELENBP1 蛋白结构

SBP56

SBP56: 56kDa selenium binding protein (SBP56) (7 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
蛋白主名 其他名称

methanethiol oxidase

56 kDa selenium-binding protein

SELENBP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SELENBP1 Q13228 MSRA Homo sapiens Q9UJ68
Y2H Array
32296183
Intra SELENBP1 Q13228 MSRA Homo sapiens Q9UJ68
Y2H Prey Pooling
32296183
Intra SELENBP1 Q13228 MSRA Homo sapiens Q9UJ68
Validated Y2H
32296183
Intra SELENBP1 Q13228 THAP12 Homo sapiens O43422
Y2H Prey Pooling
32296183
Intra SELENBP1 Q13228 THAP12 Homo sapiens O43422
Y2H Array
32296183
Intra SELENBP1 Q13228 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Intra SELENBP1 Q13228 TRIP13 Homo sapiens Q15645
Validated Y2H
32296183
Intra SELENBP1 Q13228 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra SELENBP1 Q13228 TRIP13 Homo sapiens Q15645
Y2H Pooling
16189514
Intra SELENBP1 Q13228 USP33 Homo sapiens Q8TEY7-2
Pull Down
19118533
Intra SELENBP1 Q13228 USP33 Homo sapiens Q8TEY7-2
ELISA
19118533
Intra SELENBP1 Q13228 USP33 Homo sapiens Q8TEY7-2
IF
19118533
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Extraoral Halitosis Due To Methanethiol Oxidase Deficiency

Methanethiol Oxidase Deficiency

Extraoral Halitosis Due To Mto Deficiency

EHMTO

Mto Deficiency

Extraoral Halitosis With Dimethylsulfoxiduria

Autosomal Recessive Extra-Oral Halitosis

Mto-Deficiency
Methionine Adenosyltransferase Deficiency

Mat Deficiency

Hepatic Methionine Adenosyltransferase Deficiency

Deficiency Of Acetyl-Coa Acetyltransferase
Tyrosinemia

Hypertyrosinemia

Tyrosinemias

Hereditary Tyrosinemia

Hypertyrosinaemia

Tyrosinaemia

Hereditary Hypertyrosinemia
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12633 SELENBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SELENBP1 VGNC VGNC:64981
Bos taurus SELENBP1 VGNC VGNC:34422
Canis familiaris SELENBP1 VGNC VGNC:45981
Macaca mulatta SELENBP1 VGNC VGNC:100137
Rattus norvegicus SELENBP1 RGD RGD:620571
Mus musculus SELENBP1 MGD MGI:96825
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