1. Gene
  2. MSRA - methionine sulfoxide reductase A Gene

MSRA - methionine sulfoxide reductase A Gene

中文名称:甲硫氨酸亚砜还原酶 A

种属: Homo sapiens

同用名: PMSR

基因 ID: 4482 | 基因类型: protein coding

关于 MSRA

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:10,054,292-10,428,891 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 109 orthologues and 3 paralogues. Broad expression in kidney (RPKM 12.0), bone marrow (RPKM 3.1) and 21 other tissues.

功能概要

该基因编码一种普遍存在且高度保守的蛋白质,可将甲硫氨酸亚砜酶促还原为甲硫氨酸。人类和动物研究表明在肾脏和神经组织中的表达水平最高。该蛋白质在修复氧化损伤的蛋白质中发挥作用,以恢复生物活性。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 5 月]

This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

MSRA 基因产物(4)

mRNA Protein Name
NM_001135670.3 NP_001129142.1 mitochondrial peptide methionine sulfoxide reductase isoform b
NM_001135671.3 NP_001129143.1 mitochondrial peptide methionine sulfoxide reductase isoform c
NM_001199729.3 NP_001186658.1 mitochondrial peptide methionine sulfoxide reductase isoform d
NM_012331.5 NP_036463.1 mitochondrial peptide methionine sulfoxide reductase isoform a precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MSRA 蛋白结构

PMSR

PMSR: Peptide methionine sulfoxide reductase (67 - 220)

  • 0
  • 100
  • 200
  • 235 a.a.
蛋白主名 其他名称

mitochondrial peptide methionine sulfoxide reductase

cytosolic methionine-S-sulfoxide reductase

MSRA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MSRA Q9UJ68 UBASH3B Homo sapiens Q8TF42
Anti Tag CoIP
33961781
Intra MSRA Q9UJ68 FBXL3 Homo sapiens Q9UKT7
Validated Y2H
32296183
Intra MSRA Q9UJ68 HPCAL4 Homo sapiens Q9UM19
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease

PARK2

Pdj

Autosomal Recessive Juvenile Parkinson Disease 2

Epdf

Parkinson Disease, Juvenile, Type 2

Parkinson'S Disease 2

Autosomal Recessive Juvenile Parkinson Disease

Early-Onset Parkinson Disease

Parkinson Disease 2

Parkinson Disease, Juvenile, Autosomal Recessive

Parkinsonism, Early-Onset, With Diurnal Fluctuation

Autosomal Recessive Juvenile Parkinson'S Disease 2

Jp

Juvenile Parkinsonism

Parkinson Disease Autosomal Recessive, Early Onset

Parkinsonism, Early Onset, With Diurnal Fluctuation

Yopd

Autosomal Recessive Early-Onset Parkinson Disease Type 2

Chromosome 6-Linked Autosomal Recessive Parkinsonism

Early-Onset Parkinsonism With Diurnal Fluctuation

Parkinsonism Young Adult Onset

Parkinson Disease, Type 2

Parkinsonism, Juvenile

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus MSRA VGNC VGNC:31705
Mus musculus MSRA MGD MGI:106916
Rattus norvegicus MSRA RGD RGD:70979
Macaca mulatta MSRA VGNC VGNC:74940
Felis catus MSRA VGNC VGNC:68330
Canis familiaris MSRA VGNC VGNC:43449