SPRY3 - sprouty RTK signaling antagonist 3 Gene

中文名称：芽状 RTK 信号拮抗因子 3

种属: Homo sapiens

同用名: spry-3

基因 ID: 10251 | 基因类型: protein coding

关于 SPRY3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,612,586-155,782,459 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 3 paralogues. Low expression observed in reference dataset.

功能概要

参与 MAPK 级联的负调控。预测位于膜中。预计在胞质溶胶中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Involved in negative regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SPRY3 基因产物(5)

mRNA	Protein	Name
NM_001304990.2	NP_001291919.1	protein sprouty homolog 3
NM_001394353.1	NP_001381282.1	protein sprouty homolog 3
NM_001394354.1	NP_001381283.1	protein sprouty homolog 3
NM_001394355.1	NP_001381284.1	protein sprouty homolog 3
NM_005840.4	NP_005831.1	protein sprouty homolog 3

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17974561	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of MAPK cascade	IMP IMP: 通过突变表型推断	30878395	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPRY3 蛋白结构

Sprouty

0
100
200
288 a.a.

蛋白主名

其他名称

protein sprouty homolog 3

antagonist of FGF signaling

SPRY3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SPRY3	O43610	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	SPRY3	O43610	LCE3E	Homo sapiens	Q5T5B0	Validated Y2H	32296183
Intra	SPRY3	O43610	LCE1B	Homo sapiens	Q5T7P3	Validated Y2H	32296183
Intra	SPRY3	O43610	KRT34	Homo sapiens	O76011	Validated Y2H	32296183
Intra	SPRY3	O43610	SLC39A7	Homo sapiens	Q92504	Validated Y2H	32296183
Intra	SPRY3	O43610	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	SPRY3	O43610	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	SPRY3	O43610	LCE1F	Homo sapiens	Q5T754	Validated Y2H	32296183
Intra	SPRY3	O43610	LCE1A	Homo sapiens	Q5T7P2	Validated Y2H	32296183
Intra	SPRY3	O43610	GNE	Homo sapiens	Q9Y223-2	Validated Y2H	32296183
Intra	SPRY3	O43610	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SPRY3	O43610	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SPRY3	O43610	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	SPRY3	O43610	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	SPRY3	O43610	ZDHHC17	Homo sapiens	Q8IUH5	Validated Y2H	32296183
Intra	SPRY3	O43610	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	SPRY3	O43610	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	SPRY3	O43610	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	SPRY3	O43610	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	SPRY3	O43610	LCE3D	Homo sapiens	Q9BYE3	Validated Y2H	32296183
Intra	SPRY3	O43610	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	SPRY3	O43610	VSNL1	Homo sapiens	P62760	Validated Y2H	32296183
Intra	SPRY3	O43610	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	SPRY3	O43610	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	SPRY3	O43610	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	SPRY3	O43610	LCE3A	Homo sapiens	Q5TA76	Validated Y2H	32296183
Intra	SPRY3	O43610	MAPKBP1	Homo sapiens	O60336	Validated Y2H	32296183
Intra	SPRY3	O43610	CHRD	Homo sapiens	Q9H2X0	Validated Y2H	32296183
Intra	SPRY3	O43610	R3HDM2	Homo sapiens	Q9Y2K5	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome	Nfls
LGSS	Neurofibromatosis 1-Like Syndrome
Neurofibromatosis Type 1 Like Syndrome	Nf1-Like Syndrome
Neurofibromatosis, Type 1-Like Syndrome

Intellectual Developmental Disorder, X-Linked 108

MRX108	X-Linked Intellectual Developmental Disorder 108
Mental Retardation, X-Linked 108	Mental Retardation, X-Linked, Type 108

Colorblindness, Partial, Protan Series

Protanopia	Red Color Blindness
Protan Defect	CBP
Red Colorblindness	Colorblindness, Protan
Color Blindness, Red

Red-Green Color Blindness

Deutan Defect	Deuteranopia
Reduced Red-Green Discrimination	Color Blindness, Red-Green
Colorblindness, Partial, Deutan Series

Multiminicore Disease

Multiminicore Myopathy	Mmd
Minicore Disease	Minicore Myopathy
Multi-Core Congenital Myopathy	Multi-Core Disease
Multi-Minicore Disease	Multicore Disease
Multicore Myopathy	Minicore Myopathy With External Ophthalmoplegia

Malignant Hyperthermia

Anesthesia Related Hyperthermia	Malignant Hyperpyrexia Due To Anesthesia
Hyperpyrexia, Malignant	Hyperthermia, Malignant
Malignant Hyperpyrexia	Mhs
Malignant Fever

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13723	SPRY3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SPRY3	VGNC	VGNC:65651
Mus musculus	SPRY3	MGD	MGI:1345188
Bos taurus	SPRY3	VGNC	VGNC:35243
Rattus norvegicus	SPRY3	RGD	RGD:1562172

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SPRY3 - sprouty RTK signaling antagonist 3 Gene

关于 SPRY3

功能概要

SPRY3 基因产物(5)

SPRY3 蛋白结构

SPRY3 蛋白互作信息

关联疾病

直系同源

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SPRY3 - sprouty RTK signaling antagonist 3 Gene

关于 SPRY3

功能概要

SPRY3 基因产物(5)

SPRY3 蛋白结构

SPRY3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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Z