2. Gene
  3. SLC39A7 - solute carrier family 39 member 7 Gene

SLC39A7 - solute carrier family 39 member 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 39 成员 7

种属: Homo sapiens

同用名: KE4; AGM9; HKE4; ZIP7; RING5; H2-KE4; D6S115E; D6S2244E

基因 ID: 7922 | 基因类型: protein coding

关于 SLC39A7

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,200,867-33,204,437 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 175 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 58.8), placenta (RPKM 52.4) and 25 other tissues.

功能概要

该基因编码的蛋白质将锌从高尔基体和内质网转运至细胞质。这种转运可能对酪氨酸激酶的激活很重要，其中一些可能与癌症进展有关。因此，编码蛋白的调节可用作抗癌治疗剂。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 1 月]

The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in Cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

SLC39A7 基因产物(3)

mRNA Protein Name
NM_001077516.2 NP_001070984.1 zinc transporter SLC39A7 isoform 1 precursor
NM_001288777.2 NP_001275706.1 zinc transporter SLC39A7 isoform 2
NM_006979.3 NP_008910.2 zinc transporter SLC39A7 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22317921 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
14525538 GOA
enables zinc ion transmembrane transporter activity IMP
IMP: 通过突变表型推断
30718914 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell differentiation IMP
IMP: 通过突变表型推断
30718914 GOA
involved in intracellular zinc ion homeostasis IMP
IMP: 通过突变表型推断
29980658 GOA
involved in regulation of ferroptosis IMP
IMP: 通过突变表型推断
33608508 GOA
involved in zinc ion transmembrane transport IDA
IDA: 通过直接分析推断
14525538 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
14525538 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
29980658 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC39A7 蛋白结构

Zip

Zip: ZIP Zinc transporter (133 - 466)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
蛋白主名 其他名称

zinc transporter SLC39A7

HLA class II region expressed gene KE4

SLC39A7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC39A7 Q92504 LCE4A Homo sapiens Q5TA78
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 LCE4A Homo sapiens Q5TA78
Y2H Array
32296183
Intra SLC39A7 Q92504 LCE2D Homo sapiens Q5TA82
Y2H Array
32296183
Intra SLC39A7 Q92504 LCE2D Homo sapiens Q5TA82
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra SLC39A7 Q92504 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra SLC39A7 Q92504 TNFRSF10D Homo sapiens Q9UBN6
Validated Y2H
32296183
Intra SLC39A7 Q92504 TNFRSF10D Homo sapiens Q9UBN6
Y2H Array
32296183
Intra SLC39A7 Q92504 TNFRSF10D Homo sapiens Q9UBN6
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra SLC39A7 Q92504 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 LCE5A Homo sapiens Q5TCM9
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 LCE5A Homo sapiens Q5TCM9
Y2H Array
32296183
Intra SLC39A7 Q92504 LCE1F Homo sapiens Q5T754
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 LCE1F Homo sapiens Q5T754
Y2H Array
32296183
Intra SLC39A7 Q92504 WFDC12 Homo sapiens Q8WWY7
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 WFDC12 Homo sapiens Q8WWY7
Y2H Array
32296183
Intra SLC39A7 Q92504 LCE1A Homo sapiens Q5T7P2
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra SLC39A7 Q92504 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra SLC39A7 Q92504 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 RSPO2 Homo sapiens Q6UXX9-2
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 RSPO2 Homo sapiens Q6UXX9-2
Y2H Array
32296183
Intra SLC39A7 Q92504 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra SLC39A7 Q92504 SPRY3 Homo sapiens O43610
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 SPRY3 Homo sapiens O43610
Y2H Array
32296183
Intra SLC39A7 Q92504 SLC34A2 Homo sapiens O95436-2
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 SLC34A2 Homo sapiens O95436-2
Y2H Array
32296183
Intra SLC39A7 Q92504 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra SLC39A7 Q92504 UNC93A Homo sapiens Q86WB7-2
Y2H Array
32296183
Intra SLC39A7 Q92504 UNC93A Homo sapiens Q86WB7-2
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra SLC39A7 Q92504 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
Intra SLC39A7 Q92504 LELP1 Homo sapiens Q5T871
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 LELP1 Homo sapiens Q5T871
Y2H Array
32296183
Intra SLC39A7 Q92504 CSNK2A1 Homo sapiens P68400
IF
22317921
Intra SLC39A7 Q92504 CSNK2A1 Homo sapiens P68400
Anti Bait CoIP
22317921
Intra SLC39A7 Q92504 RGS17 Homo sapiens Q9UGC6
Validated Y2H
32296183
Intra SLC39A7 Q92504 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 RGS17 Homo sapiens Q9UGC6
Y2H Array
32296183
Intra SLC39A7 Q92504 KCNF1 Homo sapiens Q9H3M0
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 KCNF1 Homo sapiens Q9H3M0
Validated Y2H
32296183
Intra SLC39A7 Q92504 KCNF1 Homo sapiens Q9H3M0
Y2H Array
32296183
Intra SLC39A7 Q92504 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra SLC39A7 Q92504 CRCT1 Homo sapiens Q9UGL9
Validated Y2H
32296183
Intra SLC39A7 Q92504 CRCT1 Homo sapiens Q9UGL9
Y2H Array
32296183
Intra SLC39A7 Q92504 CRCT1 Homo sapiens Q9UGL9
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
Intra SLC39A7 Q92504 SMCP Homo sapiens P49901
Y2H Array
32296183
Intra SLC39A7 Q92504 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra SLC39A7 Q92504 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra SLC39A7 Q92504 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Agammaglobulinemia 9, Autosomal Recessive

AGM9

Agammaglobulinemia, Autosomal Recessive, Due To Slc39a7 Defect
Agammaglobulinemia 9
Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica

AEZ

Enteropathica

Brandt Syndrome

Ae

Acrodermatitis Enteropathica Zinc Deficiency Type

Danbolt-Cross Syndrome

Acrodermatitis Enteropathica, Zinc Deficiency Type

Inherited Zinc Deficiency

Acrodermatitis Enteropathica, Zinc Deficiency

Danbolt-Closs Syndrome

Primary Zinc Malabsorption Syndrome
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like

Scd-Eds

EDSSPD3

Ehlers-Danlos Syndrome Spondylodysplastic Type 3

Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type

Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome

Slc39a13-Related Speds

Slc39a13-Related Spondylodysplastic Eds

Spondylocheirodysplastic Ehlers-Danlos Syndrome

Speds-Slc39a13

Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia

Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Enophthalmos
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114395 NVS-ZP7-4 Inhibitor 98.85% 否
HY-114395A (R)-NVS-ZP7-4 98.80% 否
HY-RS13238 SLC39A7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SLC39A7 VGNC VGNC:46406
Mus musculus SLC39A7 MGD MGI:95909
Macaca mulatta SLC39A7 VGNC VGNC:77592
Rattus norvegicus SLC39A7 RGD RGD:1593280
Bos taurus SLC39A7 VGNC VGNC:34867
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