1. Gene
  2. SMCP - sperm mitochondria associated cysteine rich protein Gene

SMCP - sperm mitochondria associated cysteine rich protein Gene

中文名称:精子线粒体相关富半胱氨酸蛋白

种属: Homo sapiens

同用名: MCS; MCSP; HSMCSGEN1

基因 ID: 4184 | 基因类型: protein coding

关于 SMCP

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,878,322-152,885,047 (from NCBI)

This gene has 1 transcript (splice variant) and 29 orthologues. Restricted expression toward testis (RPKM 221.5).

功能概要

精子线粒体在形态和亚细胞定位方面与体细胞不同。它们被拉长、变平并沿圆周排列,在精子鞭毛的中段形成一个螺旋盘绕的鞘。由该基因编码的蛋白质定位于与线粒体外膜相关的囊膜,被认为在精子线粒体鞘的螺旋结构的组织和稳定中发挥作用。[RefSeq 提供,2008 年 7 月]

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]

SMCP 基因产物(1)

mRNA Protein Name
NM_030663.3 NP_109588.2 sperm mitochondrial-associated cysteine-rich protein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

sperm mitochondrial-associated cysteine-rich protein

testicular tissue protein Li 119

SMCP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SMCP P49901 KRTAP10-8 Homo sapiens P60410 32296183
种属内
SMCP P49901 KRTAP10-8 Homo sapiens P60410 32296183
种属内
SMCP P49901 KRTAP10-8 Homo sapiens P60410 32296183
种属内
SMCP P49901 KRTAP10-9 Homo sapiens P60411 32296183
种属内
SMCP P49901 KRTAP10-9 Homo sapiens P60411 25416956
种属内
SMCP P49901 KRTAP10-9 Homo sapiens P60411 32296183
种属内
SMCP P49901 KRTAP10-9 Homo sapiens P60411 32296183
种属内
SMCP P49901 KRTAP10-5 Homo sapiens P60370 25416956
种属内
SMCP P49901 KRTAP10-7 Homo sapiens P60409 32296183
种属内
SMCP P49901 KRTAP10-7 Homo sapiens P60409 25416956
种属内
SMCP P49901 KRTAP10-7 Homo sapiens P60409 32296183
种属内
SMCP P49901 KRTAP10-7 Homo sapiens P60409 25416956
种属内
SMCP P49901 KRTAP10-7 Homo sapiens P60409 32296183
种属内
SMCP P49901 KRTAP4-2 Homo sapiens Q9BYR5 32296183
种属内
SMCP P49901 KRTAP12-4 Homo sapiens P60329 32296183
种属内
SMCP P49901 KRTAP9-4 Homo sapiens Q9BYQ2 25416956
种属内
SMCP P49901 KRTAP9-4 Homo sapiens Q9BYQ2 25416956
种属内
SMCP P49901 KRTAP12-1 Homo sapiens P59990 32296183
种属内
SMCP P49901 KRTAP10-11 Homo sapiens P60412 32296183
种属内
SMCP P49901 LCE1B Homo sapiens Q5T7P3 32296183
种属内
SMCP P49901 LCE4A Homo sapiens Q5TA78 32296183
种属内
SMCP P49901 LCE4A Homo sapiens Q5TA78 25416956
种属内
SMCP P49901 LCE4A Homo sapiens Q5TA78 25416956
种属内
SMCP P49901 LCE4A Homo sapiens Q5TA78 25416956
种属内
SMCP P49901 LCE2D Homo sapiens Q5TA82 32296183
种属内
SMCP P49901 VASN Homo sapiens Q6EMK4 32296183
种属内
SMCP P49901 KRTAP5-6 Homo sapiens Q6L8G9 32296183
种属内
SMCP P49901 KRTAP5-6 Homo sapiens Q6L8G9 25416956
种属内
SMCP P49901 KRTAP5-6 Homo sapiens Q6L8G9 25416956
种属内
SMCP P49901 KRTAP5-6 Homo sapiens Q6L8G9 25416956
种属内
SMCP P49901 KRTAP4-11 Homo sapiens Q9BYQ6 25416956
种属内
SMCP P49901 KRTAP4-11 Homo sapiens Q9BYQ6 25416956
种属内
SMCP P49901 KRTAP4-11 Homo sapiens Q9BYQ6 32296183
种属内
SMCP P49901 KRTAP4-11 Homo sapiens Q9BYQ6 25416956
种属内
SMCP P49901 KRTAP4-7 Homo sapiens Q9BYR0 25416956
种属内
SMCP P49901 KRTAP4-7 Homo sapiens Q9BYR0 25416956
种属内
SMCP P49901 KRTAP9-3 Homo sapiens Q9BYQ3 32296183
种属内
SMCP P49901 KRTAP9-3 Homo sapiens Q9BYQ3 32296183
种属内
SMCP P49901 KRTAP9-3 Homo sapiens Q9BYQ3 32296183
种属内
SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4 25416956
种属内
SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
种属内
SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
种属内
SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4 25416956
种属内
SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
种属内
SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4 25416956
种属内
SMCP P49901 KRT34 Homo sapiens O76011 32296183
种属内
SMCP P49901 KRT34 Homo sapiens O76011 32296183
种属内
SMCP P49901 SLC39A7 Homo sapiens Q92504 32296183
种属内
SMCP P49901 KRTAP1-5 Homo sapiens Q9BYS1 32296183
种属内
SMCP P49901 KRTAP1-5 Homo sapiens Q9BYS1 32296183
种属内
SMCP P49901 KRTAP1-5 Homo sapiens Q9BYS1 32296183
种属内
SMCP P49901 LCE1D Homo sapiens Q5T752 32296183
种属内
SMCP P49901 KRTAP1-3 Homo sapiens Q8IUG1 32296183
种属内
SMCP P49901 KRTAP1-3 Homo sapiens Q8IUG1 32296183
种属内
SMCP P49901 LCE1E Homo sapiens Q5T753 32296183
种属内
SMCP P49901 LCE5A Homo sapiens Q5TCM9 32296183
种属内
SMCP P49901 PCSK5 Homo sapiens Q92824-2 32296183
种属内
SMCP P49901 LCE1F Homo sapiens Q5T754 32296183
种属内
SMCP P49901 KRTAP4-4 Homo sapiens Q9BYR3 32296183
种属内
SMCP P49901 KRTAP4-4 Homo sapiens Q9BYR3 32296183
种属内
SMCP P49901 KRTAP4-4 Homo sapiens Q9BYR3 32296183
种属内
SMCP P49901 KRTAP5-2 Homo sapiens Q701N4 32296183
种属内
SMCP P49901 KRTAP5-2 Homo sapiens Q701N4 32296183
种属内
SMCP P49901 KRTAP5-2 Homo sapiens Q701N4 32296183
种属内
SMCP P49901 KRTAP9-8 Homo sapiens Q9BYQ0 32296183
种属内
SMCP P49901 KRTAP9-8 Homo sapiens Q9BYQ0 32296183
种属内
SMCP P49901 KRTAP9-8 Homo sapiens Q9BYQ0 32296183
种属内
SMCP P49901 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
SMCP P49901 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
SMCP P49901 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
SMCP P49901 LCE1A Homo sapiens Q5T7P2 32296183
种属内
SMCP P49901 KRTAP5-4 Homo sapiens Q6L8H1 32296183
种属内
SMCP P49901 LCE2C Homo sapiens Q5TA81 32296183
种属内
SMCP P49901 KRTAP5-3 Homo sapiens Q6L8H2 32296183
种属内
SMCP P49901 LCE3B Homo sapiens Q5TA77 32296183
种属内
SMCP P49901 GUCD1 Homo sapiens Q96NT3-2 32296183
种属内
SMCP P49901 KRTAP4-5 Homo sapiens Q9BYR2 32296183
种属内
SMCP P49901 KRTAP4-5 Homo sapiens Q9BYR2 32296183
种属内
SMCP P49901 KRTAP5-11 Homo sapiens Q6L8G4 32296183
种属内
SMCP P49901 NOTCH2NLC Homo sapiens P0DPK4 32296183
种属内
SMCP P49901 NOTCH2NLC Homo sapiens P0DPK4 32296183
种属内
SMCP P49901 MACO1 Homo sapiens Q8N5G2 32296183
种属内
SMCP P49901 KRTAP4-1 Homo sapiens Q9BYQ7 32296183
种属内
SMCP P49901 KRTAP4-1 Homo sapiens Q9BYQ7 32296183
种属内
SMCP P49901 DYNLL1 Homo sapiens P63167 32296183
种属内
SMCP P49901 DYNLL1 Homo sapiens P63167 32296183
种属内
SMCP P49901 DYNLL1 Homo sapiens P63167 32296183
种属内
SMCP P49901 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
SMCP P49901 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
SMCP P49901 MT1M Homo sapiens Q8N339 32296183
种属内
SMCP P49901 RGS17 Homo sapiens Q9UGC6 25416956
种属内
SMCP P49901 RGS17 Homo sapiens Q9UGC6 25416956
种属内
SMCP P49901 RGS17 Homo sapiens Q9UGC6 25416956
种属内
SMCP P49901 KRTAP5-9 Homo sapiens P26371 32296183
种属内
SMCP P49901 KRTAP5-9 Homo sapiens P26371 25416956
种属内
SMCP P49901 KRTAP5-9 Homo sapiens P26371 25416956
种属内
SMCP P49901 KRTAP5-9 Homo sapiens P26371 32296183
种属内
SMCP P49901 KRTAP5-9 Homo sapiens P26371 25416956
种属内
SMCP P49901 PPP1R27 Homo sapiens Q86WC6 32296183
种属内
SMCP P49901 TRIM42 Homo sapiens Q8IWZ5 32296183
种属内
SMCP P49901 TCF4 Homo sapiens P15884 25416956
种属内
SMCP P49901 UBL5 Homo sapiens Q9BZL1 32296183
种属内
SMCP P49901 C14orf119 Homo sapiens Q9NWQ9 32296183
种属内
SMCP P49901 CALCOCO2 Homo sapiens Q13137 25416956
种属内
SMCP P49901 CALCOCO2 Homo sapiens Q13137 25416956
种属内
SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66 25416956
种属内
SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66 16189514
种属内
SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66 32296183
种属内
SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66 32296183
种属内
SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66 32296183
种属内
SMCP P49901 DYNLL2 Homo sapiens Q96FJ2 32296183
种属内
SMCP P49901 DYNLL2 Homo sapiens Q96FJ2 32296183
种属内
SMCP P49901 DYNLL2 Homo sapiens Q96FJ2 32296183
种属内
SMCP P49901 PLSCR3 Homo sapiens Q9NRY6 32296183
种属内
SMCP P49901 LCE3A Homo sapiens Q5TA76 32296183
种属内
SMCP P49901 NOTCH2NLA Homo sapiens Q7Z3S9 31515488
种属内
SMCP P49901 KRT31 Homo sapiens Q15323 32296183
种属内
SMCP P49901 KRT31 Homo sapiens Q15323 32296183
种属内
SMCP P49901 KRT31 Homo sapiens Q15323 32296183
种属内
SMCP P49901 KRT31 Homo sapiens Q15323 25416956
种属内
SMCP P49901 PLEKHG4 Homo sapiens Q58EX7 32296183
种属内
SMCP P49901 PLEKHG4 Homo sapiens Q58EX7 32296183
种属内
SMCP P49901 PLEKHG4 Homo sapiens Q58EX7 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure 21

SPGF21

Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility

Corneal Dystrophy, Subepithelial Mucinous

Subepithelial Mucinous Corneal Dystrophy

SMCD

Infertility
Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome

Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SMCP RGD RGD:3069
Canis familiaris SMCP VGNC VGNC:46552
Mus musculus SMCP MGD MGI:96945
Macaca mulatta SMCP VGNC VGNC:77816
Bos taurus SMCP VGNC VGNC:59191