MIPOL1 - mirror-image polydactyly 1 Gene

中文名称：镜样多指畸形 1

种属: Homo sapiens

同用名: CCDC193

基因 ID: 145282 | 基因类型: protein coding

关于 MIPOL1

Cytogenetic location: 14q13.3-q21.1 Genomic coordinates (GRCh38): 14:37,197,937-37,585,618 (from NCBI)

This gene has 30 transcripts (splice variants) and 177 orthologues. Broad expression in prostate (RPKM 1.7), testis (RPKM 0.6) and 20 other tissues.

功能概要

该基因编码含有卷曲螺旋结构域的蛋白质。所编码的蛋白质可能起到肿瘤抑制因子的作用。导致由该位点编码的蛋白质截断的易位与镜像多指畸形有关，也称为 Laurin-Sandrow 综合症。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2010 年 9 月]

This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2010]

MIPOL1 基因产物(14)

mRNA	Protein	Name
NM_001195296.2	NP_001182225.1	mirror-image polydactyly gene 1 protein isoform 1
NM_001195297.2	NP_001182226.1	mirror-image polydactyly gene 1 protein isoform 1
NM_001388067.1	NP_001374996.1	mirror-image polydactyly gene 1 protein isoform 1
NM_001388068.1	NP_001374997.1	mirror-image polydactyly gene 1 protein isoform 1
NM_001388069.1	NP_001374998.1	mirror-image polydactyly gene 1 protein isoform 2
NM_001388070.1	NP_001374999.1	mirror-image polydactyly gene 1 protein isoform 3
NM_001388071.1	NP_001375000.1	mirror-image polydactyly gene 1 protein isoform 3
NM_001388072.1	NP_001375001.1	mirror-image polydactyly gene 1 protein isoform 3
NM_001388073.1	NP_001375002.1	mirror-image polydactyly gene 1 protein isoform 4
NM_001388074.1	NP_001375003.1	mirror-image polydactyly gene 1 protein isoform 5
NM_001388075.1	NP_001375004.1	mirror-image polydactyly gene 1 protein isoform 5
NM_001388077.1	NP_001375006.1	mirror-image polydactyly gene 1 protein isoform 6
NM_001412440.1	NP_001399369.1	mirror-image polydactyly gene 1 protein isoform 7
NM_138731.7	NP_620059.1	mirror-image polydactyly gene 1 protein isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	19667180	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

mirror-image polydactyly gene 1 protein

MIPOL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MIPOL1	Q8TD10	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	RTP5	Homo sapiens	Q14D33	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	FBF1	Homo sapiens	Q8TES7-6	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	FBF1	Homo sapiens	Q8TES7-6	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	FBF1	Homo sapiens	Q8TES7-6	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	TTC12	Homo sapiens	Q9H892-2	Y2H Prey Pooling	26871637
种属内	MIPOL1	Q8TD10	TTC12	Homo sapiens	Q9H892-2	Validated Y2H	26871637
种属内	MIPOL1	Q8TD10	TTC12	Homo sapiens	Q9H892-2	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	TTC12	Homo sapiens	Q9H892-2	Y2H Array	26871637
种属内	MIPOL1	Q8TD10	SSX3	Homo sapiens	Q99909	Y2H Array	31515488
种属内	MIPOL1	Q8TD10	SSX3	Homo sapiens	Q99909	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	SSX3	Homo sapiens	Q99909	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	FAM124B	Homo sapiens	Q9H5Z6-2	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	SNAP91	Homo sapiens	O60641-3	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	SNAP91	Homo sapiens	O60641-3	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	PRPF31	Homo sapiens	Q8WWY3	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	SNTG2	Homo sapiens	Q9NY99-2	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	SNTG2	Homo sapiens	Q9NY99-2	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	SNTG2	Homo sapiens	Q9NY99-2	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	NEBL	Homo sapiens	O76041	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	ZGPAT	Homo sapiens	Q8N5A5	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	ATP5PO	Homo sapiens	P48047	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	ATP5PO	Homo sapiens	P48047	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	MCM7	Homo sapiens	P33993	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	MCM7	Homo sapiens	P33993	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	CCT3	Homo sapiens	P49368	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	TSEN15	Homo sapiens	Q8WW01	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	GADD45GIP1	Homo sapiens	Q8TAE8	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	EIF4E2	Homo sapiens	O60573	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	UBE2K	Homo sapiens	P61086	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	UBE2K	Homo sapiens	P61086	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	ANKRD23	Homo sapiens	Q86SG2	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	ANKRD23	Homo sapiens	Q86SG2	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	MYLIP	Homo sapiens	Q8WY64	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	MYLIP	Homo sapiens	Q8WY64	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	STMN3	Homo sapiens	Q9NZ72	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	STMN3	Homo sapiens	Q9NZ72	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	STMN3	Homo sapiens	Q9NZ72	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	LENG1	Homo sapiens	Q96BZ8	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	RBM41	Homo sapiens	Q96IZ5	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	RBM41	Homo sapiens	Q96IZ5	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	RBM41	Homo sapiens	Q96IZ5	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	TCHP	Homo sapiens	Q9BT92	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	TCHP	Homo sapiens	Q9BT92	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	MMTAG2	Homo sapiens	Q9BU76	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	RCOR3	Homo sapiens	Q9P2K3	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	CCDC120	Homo sapiens	Q96HB5	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	CCDC120	Homo sapiens	Q96HB5	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	BEX2	Homo sapiens	Q9BXY8	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	BEX2	Homo sapiens	Q9BXY8	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	CDK18	Homo sapiens	Q07002	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	CDK18	Homo sapiens	Q07002	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	CDK18	Homo sapiens	Q07002	Y2H Array	25416956
种属内	MIPOL1	Q8TD10	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	PAX6	Homo sapiens	P26367	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	UTP25	Homo sapiens	Q68CQ4	Validated Y2H	25416956
种属内	MIPOL1	Q8TD10	UTP25	Homo sapiens	Q68CQ4	Y2H Array	29892012
种属内	MIPOL1	Q8TD10	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	EAF1	Homo sapiens	Q96JC9	Y2H Prey Pooling	25416956
种属内	MIPOL1	Q8TD10	DAXX	Homo sapiens	Q9UER7	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
种属内	MIPOL1	Q8TD10	TTC23	Homo sapiens	Q5W5X9-3	Y2H Array	32296183
种属内	MIPOL1	Q8TD10	TTC23	Homo sapiens	Q5W5X9-3	Y2H Prey Pooling	32296183
种属内	MIPOL1	Q8TD10	USH1C	Homo sapiens	Q9Y6N9	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Polydactyly

Non-Syndromic Polydactyly	Polydactyly, Postaxial
Postaxial Polydactyly	Supernumerary Digit
Extra Digits	Hyperdactyly
Polydactylia	Polydactylism
Supernumerary Digits

Laurin-Sandrow Syndrome

Sandrow Syndrome	Tetramelic Mirror-Image Polydactyly
Mirror-Image Polydactyly	Mirror Hands And Feet With Nasal Defects
Tmip	LSS
Mip	Mirror Hands And Feets-Nasal Defects Syndrome
Fibula And Ulna, Duplication Of, With Absence Of Tibia And Radius	Miccor Hands And Feet With Nasal Defects
Mipduplication Of Fibuland Ulna With Absence Of Tibia And Radius	Fibula Ulna Duplication Tibia Radius Absence
Laurin Sandrow Syndrome	Duplication Of Fibula And Ulna With Absence Of Tibia And Radius
Segmental Laurin-Sandrow Syndrome	Laurin-Sandrow Syndrome, Segmental

Bronchus Adenoma

Bronchial Adenoma

Adenoma Of The Bronchus

Acute Laryngitis

Acute Laryngitis Nos	Laryngeal Inflammation
Laryngitis Nos	Larynx Inflammation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08462	MIPOL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MIPOL1	VGNC	VGNC:106823
Canis familiaris	MIPOL1	VGNC	VGNC:43243
Felis catus	MIPOL1	VGNC	VGNC:80911
Rattus norvegicus	MIPOL1	RGD	RGD:6504372
Mus musculus	MIPOL1	MGD	MGI:1920740
Macaca mulatta	MIPOL1	VGNC	VGNC:74801

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