2. Gene
  3. TSEN15 - tRNA splicing endonuclease subunit 15 Gene

TSEN15 - tRNA splicing endonuclease subunit 15 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：tRNA 剪接核酸内切酶亚基 15

种属: Homo sapiens

同用名: PCH2F; sen15; C1orf19

基因 ID: 116461 | 基因类型: protein coding

关于 TSEN15

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:184,051,730-184,097,485 (from NCBI)

This gene has 20 transcripts (splice variants), 191 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 5.4), brain (RPKM 4.2) and 25 other tissues.

功能概要

该基因编码 tRNA 剪接核酸内切酶的一个亚基，该酶催化从 tRNA 前体中去除内含子。可变剪接导致多个转录本变体。该基因在 17 号染色体上有一个假基因。[RefSeq 提供，2014 年 7 月]

This gene encodes a subunit of the tRNA splicing Endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014]

TSEN15 基因产物(5)

mRNA Protein Name
NM_001127394.4 NP_001120866.1 tRNA-splicing endonuclease subunit Sen15 isoform 2
NM_001300764.2 NP_001287693.1 tRNA-splicing endonuclease subunit Sen15 isoform 3
NM_001300766.2 NP_001287695.1 tRNA-splicing endonuclease subunit Sen15 isoform 4
NM_001363643.2 NP_001350572.1 tRNA-splicing endonuclease subunit Sen15 isoform 5
NM_052965.4 NP_443197.1 tRNA-splicing endonuclease subunit Sen15 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TSEN15 蛋白结构

Sen15

Sen15: Sen15 protein (65 - 164)

  • 0
  • 100
  • 171 a.a.
蛋白主名 其他名称

tRNA-splicing endonuclease subunit Sen15

TSEN15 tRNA splicing endonuclease subunit

TSEN15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TSEN15 Q8WW01 DNAAF6 Homo sapiens Q9NQM4
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 DNAAF6 Homo sapiens Q9NQM4
Validated Y2H
32296183
Intra TSEN15 Q8WW01 DNAAF6 Homo sapiens Q9NQM4
Y2H Array
32296183
Intra TSEN15 Q8WW01 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
Intra TSEN15 Q8WW01 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra TSEN15 Q8WW01 PLB1 Homo sapiens Q6P1J6-2
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 PLB1 Homo sapiens Q6P1J6-2
Y2H Array
32296183
Intra TSEN15 Q8WW01 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra TSEN15 Q8WW01 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra TSEN15 Q8WW01 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra TSEN15 Q8WW01 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra TSEN15 Q8WW01 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra TSEN15 Q8WW01 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra TSEN15 Q8WW01 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra TSEN15 Q8WW01 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 AIF1L Homo sapiens Q9BQI0-4
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 AIF1L Homo sapiens Q9BQI0-4
Validated Y2H
32296183
Intra TSEN15 Q8WW01 AIF1L Homo sapiens Q9BQI0-4
Y2H Array
32296183
Intra TSEN15 Q8WW01 ASB12 Homo sapiens Q8WXK4-2
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 ASB12 Homo sapiens Q8WXK4-2
Validated Y2H
32296183
Intra TSEN15 Q8WW01 ASB12 Homo sapiens Q8WXK4-2
Y2H Array
32296183
Intra TSEN15 Q8WW01 ZNF554 Homo sapiens Q86TJ5
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 ZNF554 Homo sapiens Q86TJ5
Y2H Array
32296183
Intra TSEN15 Q8WW01 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra TSEN15 Q8WW01 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 MIPOL1 Homo sapiens Q8TD10
Y2H Array
32296183
Intra TSEN15 Q8WW01 MIPOL1 Homo sapiens Q8TD10
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
32296183
Intra TSEN15 Q8WW01 ZMAT2 Homo sapiens Q96NC0
Y2H Array
32296183
Intra TSEN15 Q8WW01 ZMAT2 Homo sapiens Q96NC0
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 POLR2G Homo sapiens P62487
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 POLR2G Homo sapiens P62487
Y2H Array
32296183
Intra TSEN15 Q8WW01 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra TSEN15 Q8WW01 LRIF1 Homo sapiens Q5T3J3
Y2H Array
32296183
Intra TSEN15 Q8WW01 LRIF1 Homo sapiens Q5T3J3
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra TSEN15 Q8WW01 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra TSEN15 Q8WW01 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra TSEN15 Q8WW01 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra TSEN15 Q8WW01 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra TSEN15 Q8WW01 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra TSEN15 Q8WW01 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra TSEN15 Q8WW01 ENKD1 Homo sapiens Q9H0I2
Y2H Array
32296183
Intra TSEN15 Q8WW01 TASOR2 Homo sapiens Q5VWN6
Y2H Array
32296183
Intra TSEN15 Q8WW01 TASOR2 Homo sapiens Q5VWN6
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra TSEN15 Q8WW01 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra TSEN15 Q8WW01 TSSK2 Homo sapiens Q96PF2
Validated Y2H
32296183
Intra TSEN15 Q8WW01 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra TSEN15 Q8WW01 ARID5A Homo sapiens Q03989
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 2f

PCH2F

Pontocerebellar Hypoplasia Type 2f

Pontocerebellar Hypoplasia 2f

Doid:0112329

Hypoplasia, Pontocerebellar, Type 2f
Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2

Pontocerebellar Hypoplasia Type 2e

Pch2

PCH2E

Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy

Pontocerebellar Hypoplasia 2e

Pcca2

Progressive Cerebello-Cerebral Atrophy Type 2

Doid:0112328

Hypoplasia, Pontocerebellar, Type 2e

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2a
Primary Microcephaly

True Microcephaly

Microcephaly, Primary
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Acromesomelic Dysplasia 2b

Fibular Hypoplasia And Complex Brachydactyly

Du Pan Syndrome

AMD2B

Dupans

Acromesomelic Dysplasia-2b

Fibular Aplasia-Complex Brachydactyly Syndrome
Pontocerebellar Hypoplasia, Type 1d

PCH1D

Pontocerebellar Hypoplasia Type 1d

Pontocerebellar Hypoplasia 1d

Doid:0112323

Hypoplasia, Pontocerebellar, Type 1d
Pontocerebellar Hypoplasia, Type 4

Pontocerebellar Hypoplasia Type 4

PCH4

Olivopontocerebellar Hypoplasia

Encephalopathy Fatal Infantile With Olivopontocerebellar Hypoplasia

Encephalopathy, Fatal Infantile, With Olivopontocerebellar Hypoplasia

Fatal Infantile Encephalopathy With Olivopontocerebellar Hypoplasia

Pontocerebellar Hypoplasia 4

Young Mckeever Squier Syndrome

Hypoplasia, Pontocerebellar, Type 4
Pontocerebellar Hypoplasia, Type 10

Pontocerebellar Hypoplasia Type 10

PCH10

Clp1-Related Pontocerebellar Hypoplasia

Pontocerebellar Hypoplasia 10

Hypoplasia, Pontocerebellar, Type 10
Immunodeficiency 36

IMD36

Activated Phosphoinositide 3-Kinase Delta Syndrome 2

Immunodeficiency, Type 36
Pontocerebellar Hypoplasia, Type 3

Pontocerebellar Hypoplasia Type 3

Cerebellar Atrophy With Progressive Microcephaly

PCH3

Clam

Pch With Optic Atrophy

Pontocerebellar Hypoplasia 3

Hypoplasia, Pontocerebellar, Type 3
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15137 TSEN15 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TSEN15 MGD MGI:1913887
Felis catus TSEN15 VGNC VGNC:107958
Bos taurus TSEN15 VGNC VGNC:36410
Macaca mulatta TSEN15 VGNC VGNC:106525
Rattus norvegicus TSEN15 RGD RGD:1308584
Canis familiaris TSEN15 VGNC VGNC:47895
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