2. Gene
  3. TSSK2 - testis specific serine kinase 2 Gene

TSSK2 - testis specific serine kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：睾丸特异性丝氨酸激酶 2

种属: Homo sapiens

同用名: TSK2; DGS-G; SPOGA2; STK22B

基因 ID: 23617 | 基因类型: protein coding

关于 TSSK2

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:19,131,308-19,132,622 (from NCBI)

This gene has 1 transcript (splice variant), 177 orthologues and 17 paralogues.

功能概要

TSSK2 属于在睾丸中高度表达的丝氨酸/苏氨酸激酶家族 (Hao 等人，2004 [PubMed 15044604]) 。[OMIM 提供，2008 年 3 月]

TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]

TSSK2 基因产物(1)

mRNA Protein Name
NM_053006.5 NP_443732.3 testis-specific serine/threonine-protein kinase 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables magnesium ion binding IDA
IDA: 通过直接分析推断
20729278 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15044604 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18533145 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
20729278 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TSSK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (17 - 272)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
蛋白主名 其他名称

testis-specific serine/threonine-protein kinase 2

TSK-2

TSSK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TSSK2 Q96PF2 FAM229B Homo sapiens Q4G0N7
Y2H Prey Pooling
32296183
种属内
TSSK2 Q96PF2 FAM229B Homo sapiens Q4G0N7
Y2H Array
32296183
种属内
TSSK2 Q96PF2 HSP90AB1 Homo sapiens P08238
Lumier
22939624
种属内
TSSK2 Q96PF2 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
TSSK2 Q96PF2 TSEN15 Homo sapiens Q8WW01
Y2H Array
32296183
种属内
TSSK2 Q96PF2 TSEN15 Homo sapiens Q8WW01
Y2H Prey Pooling
32296183
种属内
TSSK2 Q96PF2 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
种属内
TSSK2 Q96PF2 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
种属内
TSSK2 Q96PF2 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
种属内
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2
Y2H Prey Pooling
32296183
种属内
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2
Pull Down
15044604
种属内
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2
Y2H Array
32296183
种属内
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2
Validated Y2H
32296183
种属内
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2-2
Protein Kinase Assay
15044604
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hyperprolinemia, Type I

Proline Oxidase Deficiency

Hyperprolinemia Type 1

HYRPRO1

Hpi

Hyperprolinemia Type I

Hyperprolinemia 1

Proline Dehydrogenase Deficiency
Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome

DGS

Hypoplasia Of Thymus And Parathyroids

Third And Fourth Pharyngeal Pouch Syndrome

22q11.2 Deletion Syndrome

Digeorge Sequence

Digeorge'S Syndrome

Pharyngeal Pouch Syndrome

Di-George Syndrome

Shprintzen Syndrome
Van Den Ende-Gupta Syndrome

VDEGS

Blepharophimosis, Arachnodactyly, And Congenital Contractures

Marden-Walker-Like Syndrome

Marden-Walker-Like Syndrome Without Psychomotor Retardation

Marden Walker Like Syndrome

Marden-Walker-Like Syndrome Without Psychmotor Retardation

Van Den Ende Gupta Syndrome

Marden Walker Like Syndrome Without Psychomotor Retardation

Blepharophimosis Arachnodactyly And Congenital Contractures
Combined D-2- And L-2-Hydroxyglutaric Aciduria

D,L-2-Hydroxyglutaric Aciduria

D2L2AD

Combined D-2-Hydroxyglutaric Acidemia And L-2-Hydroxyglutaric Acidemia

Combined D-2-Hydroxyglutaric Aciduria And L-2-Hydroxyglutaric Aciduria

D,L-2-Hga

D,L-2-Hydroxyglutaric Acidemia

Combined D,L-2-Hydroxyglutaric Aciduria
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15358 ALK inhibitor 2 Inhibitor 99.57% 否
HY-15357 ALK inhibitor 1 Inhibitor 99.62% 否
HY-RS15188 TSSK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TSSK2 VGNC VGNC:78557
Mus musculus TSSK2 MGD MGI:1347559
Felis catus TSSK2 VGNC VGNC:66644
Rattus norvegicus TSSK2 RGD RGD:1304951
Canis familiaris TSSK2 VGNC VGNC:103714
Bos taurus TSSK2 VGNC VGNC:49975
Others TSSK2 NCBI
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