1. Gene
  2. TSKS - testis specific serine kinase substrate Gene

TSKS - testis specific serine kinase substrate Gene

中文名称:睾丸特异性丝氨酸激酶底物

种属: Homo sapiens

同用名: TSKS1; TSSKS; STK22S1; PPP1R161

基因 ID: 60385 | 基因类型: protein coding

关于 TSKS

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,739,760-49,763,306 (from NCBI)

This gene has 3 transcripts (splice variants) and 101 orthologues. Restricted expression toward testis (RPKM 31.5).

功能概要

该基因可能在睾丸生理学、精子发生或精子发生中发挥作用。编码蛋白的表达在睾丸中最高,在睾丸癌中表达下调。该基因位于相关 Ras 病毒致癌基因同系物 (RRAS) 和干扰素调节因子 3 (IRF3) 基因中的 19q13.3 区域,它们均参与肿瘤发生途径和进展。[RefSeq 提供,2008 年 7 月]

This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular Cancer. The gene is localized to the region 19q13.3 among the related Ras viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]

TSKS 基因产物(1)

mRNA Protein Name
NM_021733.2 NP_068379.1 testis-specific serine kinase substrate
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15044604 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
18533145 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centriole IDA
IDA: 通过直接分析推断
18495105 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TSKS 蛋白结构

TSKS

TSKS: Testis-specific serine kinase substrate (26 - 592)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
蛋白主名 其他名称

testis-specific serine kinase substrate

STK22 substrate 1

TSKS 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TSKS Q9UJT2 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
种属内
TSKS Q9UJT2 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
种属内
TSKS Q9UJT2 TPM3 Homo sapiens P06753
Y2H Array
32296183
种属内
TSKS Q9UJT2 TPM3 Homo sapiens P06753
Y2H Prey Pooling
32296183
种属内
TSKS Q9UJT2 TSSK1B Homo sapiens Q9BXA7
Y2H Array
32296183
种属内
TSKS Q9UJT2 TSSK1B Homo sapiens Q9BXA7
Y2H Prey Pooling
32296183
种属内
TSKS Q9UJT2 TSSK2 Homo sapiens Q96PF2
Y2H Array
32296183
种属内
TSKS Q9UJT2 TSSK2 Homo sapiens Q96PF2
Y2H
15044604
种属内
TSKS Q9UJT2 TSSK2 Homo sapiens Q96PF2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TSKS VGNC VGNC:47906
Bos taurus TSKS VGNC VGNC:36421
Rattus norvegicus TSKS RGD RGD:727784
Felis catus TSKS VGNC VGNC:66620
Macaca mulatta TSKS VGNC VGNC:79868
Mus musculus TSKS MGD MGI:1347560