MYLIP - myosin regulatory light chain interacting protein Gene

中文名称：肌球蛋白调节轻链相互作用蛋白

种属: Homo sapiens

同用名: MIR; IDOL

基因 ID: 29116 | 基因类型: protein coding

关于 MYLIP

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:16,129,086-16,163,887 (from NCBI)

This gene has 2 transcripts (splice variants), 230 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 42.5), bone marrow (RPKM 32.5) and 23 other tissues.

功能概要

ERM 蛋白家族成员 ezrin、radixin 和 moesin 是细胞骨架效应蛋白，将肌动蛋白连接到细胞表面的膜结合蛋白。肌球蛋白调节轻链相互作用蛋白 (MYLIP) 是一种新型 ERM 样蛋白，可与肌球蛋白调节轻链相互作用并抑制神经突生长。[RefSeq 提供，2008 年 7 月]

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with Myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]

MYLIP 基因产物(1)

mRNA	Protein	Name
NM_013262.4	NP_037394.2	E3 ubiquitin-protein ligase MYLIP

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cytoskeletal protein binding	IDA IDA: 通过直接分析推断	10593918	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12826659	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	21685362	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	14550572	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of neuron projection development	IMP IMP: 通过突变表型推断	10593918	GOA
involved in nervous system development	IMP IMP: 通过突变表型推断	10593918	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	14550572	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYLIP 蛋白结构

FERM_N

FERM_M

zf-C3HC4_3

0
100
200
300
400
445 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase MYLIP

E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor

MYLIP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MYLIP	Q8WY64	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
种属内	MYLIP	Q8WY64	NR1D2	Homo sapiens	Q6NSM0	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	NR1D2	Homo sapiens	Q6NSM0	Y2H Array	32296183
种属内	MYLIP	Q8WY64	CNPY2	Homo sapiens	Q9Y2B0	Pull Down	12826659
种属内	MYLIP	Q8WY64	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
种属内	MYLIP	Q8WY64	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
种属内	MYLIP	Q8WY64	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
种属内	MYLIP	Q8WY64	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
种属内	MYLIP	Q8WY64	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
种属内	MYLIP	Q8WY64	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
种属内	MYLIP	Q8WY64	PAX9	Homo sapiens	P55771	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	PAX9	Homo sapiens	P55771	Y2H Array	32296183
种属内	MYLIP	Q8WY64	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
种属内	MYLIP	Q8WY64	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
种属内	MYLIP	Q8WY64	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	NHLRC4	Homo sapiens	P0CG21	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	NHLRC4	Homo sapiens	P0CG21	Y2H Array	32296183
种属内	MYLIP	Q8WY64	FAM217B	Homo sapiens	Q9NTX9	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	FAM217B	Homo sapiens	Q9NTX9	Y2H Array	32296183
种属内	MYLIP	Q8WY64	FAM217B	Homo sapiens	Q9NTX9	Validated Y2H	32296183
种属内	MYLIP	Q8WY64	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
种属内	MYLIP	Q8WY64	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
种属内	MYLIP	Q8WY64	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
种属内	MYLIP	Q8WY64	LNX2	Homo sapiens	Q8N448	Y2H Array	31515488
种属内	MYLIP	Q8WY64	LNX2	Homo sapiens	Q8N448	Y2H Array	29892012
种属内	MYLIP	Q8WY64	LNX2	Homo sapiens	Q8N448	Y2H	21516116
种属内	MYLIP	Q8WY64	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
种属内	MYLIP	Q8WY64	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
种属内	MYLIP	Q8WY64	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
种属内	MYLIP	Q8WY64	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	25416956
种属内	MYLIP	Q8WY64	ZBTB18	Homo sapiens	Q99592	Y2H Array	32296183
种属内	MYLIP	Q8WY64	ZBTB18	Homo sapiens	Q99592	Validated Y2H	32296183
种属内	MYLIP	Q8WY64	ZBTB18	Homo sapiens	Q99592	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	RASSF5	Homo sapiens	Q8WWW0	Validated Y2H	25416956
种属内	MYLIP	Q8WY64	RASSF5	Homo sapiens	Q8WWW0	Y2H Prey Pooling	25416956
种属内	MYLIP	Q8WY64	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
种属内	MYLIP	Q8WY64	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
种属内	MYLIP	Q8WY64	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
种属内	MYLIP	Q8WY64	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
种属内	MYLIP	Q8WY64	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
种属内	MYLIP	Q8WY64	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
种属内	MYLIP	Q8WY64	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
种属内	MYLIP	Q8WY64	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	MYLIP	Q8WY64	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	MYLIP	Q8WY64	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	MYLIP	Q8WY64	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
种属内	MYLIP	Q8WY64	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
种属内	MYLIP	Q8WY64	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
种属内	MYLIP	Q8WY64	ZBTB16	Homo sapiens	Q05516	Y2H Array	32296183
种属内	MYLIP	Q8WY64	ZBTB16	Homo sapiens	Q05516	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	INO80B	Homo sapiens	Q9C086	Validated Y2H	32296183
种属内	MYLIP	Q8WY64	INO80B	Homo sapiens	Q9C086	Y2H Array	32296183
种属内	MYLIP	Q8WY64	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	MYLIP	Q8WY64	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
种属内	MYLIP	Q8WY64	KANK4	Homo sapiens	Q5T7N3	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	KANK4	Homo sapiens	Q5T7N3	Y2H Array	32296183
种属内	MYLIP	Q8WY64	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
种属内	MYLIP	Q8WY64	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive	Arh
FHCL4	Autosomal Recessive Hypercholesterolemia
Arh1	Arh2
Autosomal Recessive Hypercholesterolemia 1	Autosomal Recessive Hypercholesterolemia 2
Fhcb1	Fhcb2
Hypercholesterolemia, Autosomal Recessive, 1, Formerly	Arh1, Formerly
Fhcb1, Formerly	Hypercholesterolemia, Autosomal Recessive, 2, Formerly
Arh2, Formerly	Fhcb2, Formerly
Familial Autosomal Recessive Hypercholesterolemia	Hypercholesterolemia, Familial, Autosomal Recessive
Hypercholesterolemia, Familial, Type 4

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08922	MYLIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MYLIP	VGNC	VGNC:75000
Mus musculus	MYLIP	MGD	MGI:2388271
Bos taurus	MYLIP	VGNC	VGNC:31805
Felis catus	MYLIP	VGNC	VGNC:63680
Rattus norvegicus	MYLIP	RGD	RGD:1305761
Canis familiaris	MYLIP	VGNC	VGNC:43548

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