2. Gene
  3. KANK4 - KN motif and ankyrin repeat domains 4 Gene

KANK4 - KN motif and ankyrin repeat domains 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：KN 基序和锚蛋白重复结构域 4

种属: Homo sapiens

同用名: ANKRD38; dJ1078M7.1

基因 ID: 163782 | 基因类型: protein coding

关于 KANK4

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,236,165-62,319,434 (from NCBI)

This gene has 4 transcripts (splice variants), 296 orthologues and 3 paralogues. Biased expression in fat (RPKM 7.4), placenta (RPKM 5.9) and 10 other tissues.

功能概要

预计参与肌动蛋白丝聚合的负调控。位于胞质溶胶和微管细胞骨架中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in negative regulation of actin filament polymerization. Located in cytosol and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

KANK4 基因产物(2)

mRNA Protein Name
NM_001320269.2 NP_001307198.1 KN motif and ankyrin repeat domain-containing protein 4 isoform 2
NM_181712.5 NP_859063.3 KN motif and ankyrin repeat domain-containing protein 4 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25961457 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KANK4 蛋白结构

KN_motif

KN_motif: KN motif (24 - 62)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (815 - 864)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (870 - 951)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 995 a.a.
蛋白主名 其他名称

KN motif and ankyrin repeat domain-containing protein 4

ankyrin repeat domain 38

KANK4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KANK4 Q5T7N3 CUL5 Homo sapiens Q93034
Validated Y2H
32296183
Intra KANK4 Q5T7N3 MYLIP Homo sapiens Q8WY64
Validated Y2H
32296183
Intra KANK4 Q5T7N3 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis
Corneal Endothelial Dystrophy

Congenital Hereditary Endothelial Dystrophy Of Cornea

Chandler Syndrome

CHED

Chandler'S Syndrome

Endothelial Corneal Dystrophy

Ched2

Maumenee Corneal Dystrophy

Corneal Dystrophy, Congenital Hereditary Endothelial

Dystrophy Of Corneal Endothelium

Corneal Endothelial Dystrophy 2

Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly

Ched2, Formerly

Corneal Endothelial Dystrophy, Autosomal Recessive

Endothelial Dystrophy

Posterior Membrane Corneal Dystrophy

Corneal Endothelial Dystrophy Type 2

Congenital Hereditary Endothelial Dystrophy Of The Cornea

Congenital Hereditary Endothelial Dystrophy Type Ii

Autosomal Recessive Ched

Autosomal Recessive Congenital Hereditary Endothelial Dystrophy

Chedii

Congenital Hereditary Endothelial Dystrophy Type 2

Infantile Hereditary Endothelial Dystrophy

Congenital Hereditary Endothelial Corneal Dystrophy

Corneal Endothelial Dystrophy 2, Autosomal Recessive

Iridocorneal Endothelial Syndrome

Dystrophy, Corneal, Endothelial

Corneal Endothelial Dystrophy 1, Autosomal Dominant
Corneal Dystrophy And Perceptive Deafness

Corneal Dystrophy-Perceptive Deafness Syndrome

CDPD

Harboyan Syndrome

Cdpd1

Corneal Dystrophy And Sensorineural Deafness

Corneal Endothelial Dystrophy And Perceptive Deafness

Corneal Dystrophy With Progressive Deafness

Congenital Corneal Dystrophy, Progressive Sensorineural Deafness

Corneal Dystrophy With Progressive Hearing Loss

Corneal Dystrophy-Perceptive Hearing Loss Syndrome

Dystrophy, Corneal, Endothelial, And Perceptive Deafness
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
Hypertensive Encephalopathy

Encephalopathy, Hypertensive
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07066 KANK4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus KANK4 VGNC VGNC:55243
Canis familiaris KANK4 VGNC VGNC:42203
Mus musculus KANK4 MGD MGI:3043381
Rattus norvegicus KANK4 RGD RGD:1307635
Felis catus KANK4 VGNC VGNC:63017
Macaca mulatta KANK4 VGNC VGNC:73916
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