RASSF5 - Ras association domain family member 5 Gene

中文名称：Ras 关联域家族成员 5

种属: Homo sapiens

同用名: RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3

基因 ID: 83593 | 基因类型: protein coding

关于 RASSF5

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,507,531-206,589,448 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 5 paralogues. Broad expression in bone marrow (RPKM 44.1), lymph node (RPKM 34.6) and 20 other tissues.

功能概要

该基因是 Ras 关联域家族的成员。它起到肿瘤抑制因子的作用，并在多种癌症中失活。编码的蛋白质定位于中心体和微管，并与 Ras、Rap1 和其他几种 Ras 样小 GTP 酶的 GTP 激活形式相关联。该蛋白调节淋巴细胞粘附并抑制细胞生长以响应激活的 Rap1 或 Ras。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several Other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RASSF5 基因产物(3)

mRNA	Protein	Name
NM_182663.4	NP_872604.1	ras association domain-containing protein 5 isoform A
NM_182664.4	NP_872605.1	ras association domain-containing protein 5 isoform B
NM_182665.4	NP_872606.1	ras association domain-containing protein 5 isoform C

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17517604	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9488663	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RASSF5 蛋白结构

C1_1

0
100
200
300
418 a.a.

蛋白主名

其他名称

ras association domain-containing protein 5

Rap1-binding protein

RASSF5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RASSF5	Q8WWW0	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
种属内	RASSF5	Q8WWW0	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
种属内	RASSF5	Q8WWW0	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
种属内	RASSF5	Q8WWW0	a8k940_human	Homo sapiens	A8K940	Validated Y2H	25416956
种属内	RASSF5	Q8WWW0	a8k940_human	Homo sapiens	A8K940	Y2H Array	25416956
种属内	RASSF5	Q8WWW0	VPS28	Homo sapiens	Q548N1	Y2H Prey Pooling	25416956
种属内	RASSF5	Q8WWW0	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
种属内	RASSF5	Q8WWW0	REL	Homo sapiens	Q04864	Validated Y2H	25416956
种属内	RASSF5	Q8WWW0	BTRC	Homo sapiens	Q9Y297	Y2H Array	31515488
种属内	RASSF5	Q8WWW0	SMAD4	Homo sapiens	Q13485	Validated Y2H	25416956
种属内	RASSF5	Q8WWW0	SMAD4	Homo sapiens	Q13485	Y2H Array	31515488
种属内	RASSF5	Q8WWW0	SMAD4	Homo sapiens	Q13485	Y2H	25502805
种属内	RASSF5	Q8WWW0	HRAS	Homo sapiens	P01112	Anti Bait CoIP	9488663
种属内	RASSF5	Q8WWW0	HRAS	Homo sapiens	P01112	Anti Tag CoIP	18596699
种属内	RASSF5	Q8WWW0	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
种属内	RASSF5	Q8WWW0	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
种属内	RASSF5	Q8WWW0	STK4	Homo sapiens	Q13043	CoIP	15109305
种属内	RASSF5	Q8WWW0	STK4	Homo sapiens	Q13043	Anti Tag CoIP	20562859
种属内	RASSF5	Q8WWW0	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24366813
种属内	RASSF5	Q8WWW0	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
种属内	RASSF5	Q8WWW0	MYLIP	Homo sapiens	Q8WY64	Y2H Array	31515488
种属内	RASSF5	Q8WWW0	MYLIP	Homo sapiens	Q8WY64	Y2H Array	25416956
种属内	RASSF5	Q8WWW0	GABARAP	Homo sapiens	O95166	Pull Down	20562859
种属内	RASSF5	Q8WWW0	RABIF	Homo sapiens	P47224	Y2H Array	25416956
种属内	RASSF5	Q8WWW0	RABIF	Homo sapiens	P47224	Y2H Prey Pooling	25416956
种属内	RASSF5	Q8WWW0	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
种属内	RASSF5	Q8WWW0	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
种属内	RASSF5	Q8WWW0	RAP2B	Homo sapiens	P61225	Y2H Array	25416956
种属内	RASSF5	Q8WWW0	RASSF2	Homo sapiens	P50749	Validated Y2H	25416956
种属内	RASSF5	Q8WWW0	RASSF2	Homo sapiens	P50749	Y2H Array	25416956
种属内	RASSF5	Q8WWW0	RASSF2	Homo sapiens	P50749	Y2H Prey Pooling	25416956
种属内	RASSF5	Q8WWW0	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24366813
种属内	RASSF5	Q8WWW0	STK3	Homo sapiens	Q13188	Anti Tag CoIP	20562859

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency	Leukocyte Adhesion Deficiency 1
LAD1	Lad
Lymphocyte Function-Associated Antigen 1 Immunodeficiency	Leukocyte Adhesion Deficiency Type I
Leukocyte Adhesion Deficiency Type 1	Linear Iga Bullous Dermatosis
Linear Iga Dermatosis	Leukocyte-Adhesion Deficiency Syndrome
Lfa1 Immunodeficiency	Congenital Leukocyte Adherence Deficiency
Lad-I	Linear Iga Disease
Leukocyte Adhesion Deficiency Syndrome	Lad 1
Lfa 1 Immunodeficiency	Linear Immunoglobulin A Dermatosis
Leucocyte Adhesion Deficiency Type 1	Leukocyte Adhesion Molecule Deficiency Type 1

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11705	RASSF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	RASSF5	VGNC	VGNC:100051
Rattus norvegicus	RASSF5	RGD	RGD:621694
Canis familiaris	RASSF5	VGNC	VGNC:45382
Mus musculus	RASSF5	MGD	MGI:1926375
Bos taurus	RASSF5	VGNC	VGNC:33761
Felis catus	RASSF5	VGNC	VGNC:64508

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