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  2. RAP2B - RAP2B, member of RAS oncogene family Gene

RAP2B - RAP2B, member of RAS oncogene family Gene

中文名称:RAP2B,RAS 致癌基因家族成员

种属: Homo sapiens

基因 ID: 5912 | 基因类型: protein coding

关于 RAP2B

Cytogenetic location: 3q25.2 Genomic coordinates (GRCh38): 3:153,162,226-153,170,627 (from NCBI)

This gene has 1 transcript (splice variant), 184 orthologues and 35 paralogues.

功能概要

这种无内含子的基因属于 Ras 相关基因家族。由这些基因编码的蛋白质与经典 Ras 蛋白质具有大约 50% 的氨基酸同一性,并且具有许多共同的结构特征。 RAP 和 Ras 蛋白之间最显着的区别在于它们的第 61 个氨基酸:RAS 中的谷氨酰胺被 RAP 蛋白中的苏氨酸取代。有证据表明该蛋白质可能被聚异戊二烯化和棕榈酰化。[RefSeq 提供,2008 年 7 月]

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical Ras proteins and have numerous structural features in common. The most striking difference between the RAP and Ras proteins resides in their 61st amino acid: glutamine in Ras is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

RAP2B 基因产物(1)

mRNA Protein Name
NM_002886.4 NP_002877.2 ras-related protein Rap-2b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP binding IDA
IDA: 通过直接分析推断
16213650 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
16213650 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in establishment of endothelial intestinal barrier IMP
IMP: 通过突变表型推断
23885123 GOA
NOT involved in microvillus assembly IMP
IMP: 通过突变表型推断
22797597 GOA
involved in platelet activation IDA
IDA: 通过直接分析推断
18582561 GOA
involved in platelet aggregation IDA
IDA: 通过直接分析推断
18582561 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in bicellular tight junction IDA
IDA: 通过直接分析推断
23885123 GOA
located in cell-cell contact zone IDA
IDA: 通过直接分析推断
23885123 GOA
located in cytosol IDA
IDA: 通过直接分析推断
18582561 GOA
located in extracellular exosome IDA
IDA: 通过直接分析推断
16540189 GOA
located in membrane IMP
IMP: 通过突变表型推断
18582561 GOA
located in membrane raft IMP
IMP: 通过突变表型推断
18582561 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16213650 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RAP2B 蛋白结构

Ras

Ras: Ras family (5 - 164)

  • 0
  • 100
  • 183 a.a.
蛋白主名 其他名称

ras-related protein Rap-2b

small GTP binding protein

RAP2B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAP2B P61225 CAMK2B Homo sapiens Q13554 25416956
种属内
RAP2B P61225 CAMK2B Homo sapiens Q13554-3 32296183
种属内
RAP2B P61225 CAMK2B Homo sapiens Q13554-3 32296183
种属内
RAP2B P61225 CAMK2B Homo sapiens Q13554-3 32296183
种属内
RAP2B P61225 RUNDC3A Homo sapiens Q59EK9-3 32296183
种属内
RAP2B P61225 RUNDC3A Homo sapiens Q59EK9-3 32296183
种属内
RAP2B P61225 RUNDC3A Homo sapiens Q59EK9-3 32296183
种属内
RAP2B P61225 RAP1GDS1 Homo sapiens P52306-5 32296183
种属内
RAP2B P61225 RAP1GDS1 Homo sapiens P52306-5 32296183
种属内
RAP2B P61225 RASSF5 Homo sapiens Q8WWW0 25416956
种属内
RAP2B P61225 RASSF5 Homo sapiens Q8WWW0 25416956
种属内
RAP2B P61225 RUNDC3A Homo sapiens Q59EK9 25416956
种属内
RAP2B P61225 RUNDC3A Homo sapiens Q59EK9 25416956
种属内
RAP2B P61225 RUNDC3A Homo sapiens Q59EK9 16189514
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia

SMC1

Smc

Smith Mccort Dysplasia

Smith-Mccort Dwarfism

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RAP2B VGNC VGNC:33720
Felis catus RAP2B VGNC VGNC:69238
Macaca mulatta RAP2B VGNC VGNC:76660
Mus musculus RAP2B MGD MGI:1921262
Canis familiaris RAP2B VGNC VGNC:52900
Rattus norvegicus RAP2B RGD RGD:620591