2. Gene
  3. HOOK1 - hook microtubule tethering protein 1 Gene

HOOK1 - hook microtubule tethering protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钩微管束缚蛋白 1

种属: Homo sapiens

同用名: HK1

基因 ID: 51361 | 基因类型: protein coding

关于 HOOK1

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:59,814,949-59,876,322 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 5 paralogues. Broad expression in testis (RPKM 15.7), colon (RPKM 10.0) and 21 other tissues.

功能概要

该基因编码卷曲螺旋蛋白 hook 家族的一个成员，它们分别通过 N 端和 C 端结构域与微管和细胞器结合。编码的蛋白质定位于离散的点状亚细胞结构，并与参与内吞作用的 Rab GTPase 家族的几个成员相互作用。人们认为将内吞膜运输与微管细胞骨架联系起来。已经确定了几种可变剪接的转录本变体，但尚未确定其中一些变体的全长性质。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule Cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

HOOK1 基因产物(1)

mRNA Protein Name
NM_015888.6 NP_056972.1 protein Hook homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18799622 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15471887 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
32073997 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in early endosome to late endosome transport IMP
IMP: 通过突变表型推断
18799622 GOA
involved in endosome organization IMP
IMP: 通过突变表型推断
18799622 GOA
involved in endosome to lysosome transport IMP
IMP: 通过突变表型推断
18799622 GOA
involved in lysosome organization IMP
IMP: 通过突变表型推断
18799622 GOA
involved in protein localization to perinuclear region of cytoplasm IMP
IMP: 通过突变表型推断
32073997 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FHF complex IDA
IDA: 通过直接分析推断
18799622 GOA
part of HOPS complex IDA
IDA: 通过直接分析推断
18799622 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15471887 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HOOK1 蛋白结构

HOOK

HOOK: HOOK protein (9 - 727)

  • 0
  • 200
  • 400
  • 600
  • 728 a.a.
蛋白主名 其他名称

protein Hook homolog 1

h-hook1

HOOK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra HOOK1 Q9UJC3 ZNF80 Homo sapiens P51504
Y2H Prey Pooling
32296183
Intra HOOK1 Q9UJC3 ZNF80 Homo sapiens P51504
Y2H Array
32296183
Intra HOOK1 Q9UJC3 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra HOOK1 Q9UJC3 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra HOOK1 Q9UJC3 HOOK3 Homo sapiens Q86VS8
Y2H
32073997
Intra HOOK1 Q9UJC3 CDK4 Homo sapiens P11802
Y2H Prey Pooling
32296183
Intra HOOK1 Q9UJC3 CDK4 Homo sapiens P11802
Y2H Array
31515488
Intra HOOK1 Q9UJC3 CDK4 Homo sapiens P11802
Validated Y2H
25416956
Intra HOOK1 Q9UJC3 CDK4 Homo sapiens P11802
Y2H Array
32296183
Intra HOOK1 Q9UJC3 TBC1D7 Homo sapiens Q9P0N9
Y2H Array
31515488
Intra HOOK1 Q9UJC3 TBC1D7 Homo sapiens Q9P0N9
Validated Y2H
25416956
Intra HOOK1 Q9UJC3 TBC1D7 Homo sapiens Q9P0N9
Y2H Array
25416956
Intra HOOK1 Q9UJC3 NCOR1 Homo sapiens O75376
Validated Y2H
32814053
Intra HOOK1 Q9UJC3 NCOR1 Homo sapiens O75376
Y2H Array
32814053
Intra HOOK1 Q9UJC3 NCOR1 Homo sapiens O75376
Y2H Pooling
32814053
Intra HOOK1 Q9UJC3 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra HOOK1 Q9UJC3 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra HOOK1 Q9UJC3 CDC5L Homo sapiens Q99459
Y2H
17043677
Intra HOOK1 Q9UJC3 ZNF785 Homo sapiens A8K8V0
Y2H Prey Pooling
25416956
Intra HOOK1 Q9UJC3 ZNF785 Homo sapiens A8K8V0
Validated Y2H
25416956
Intra HOOK1 Q9UJC3 ZNF785 Homo sapiens A8K8V0
Y2H Array
25416956
Intra HOOK1 Q9UJC3 ANKRD23 Homo sapiens Q86SG2
Y2H Array
32296183
Intra HOOK1 Q9UJC3 ANKRD23 Homo sapiens Q86SG2
Y2H Prey Pooling
32296183
Intra HOOK1 Q9UJC3 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra HOOK1 Q9UJC3 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra HOOK1 Q9UJC3 SYCE1 Homo sapiens Q8N0S2
Validated Y2H
25416956
Intra HOOK1 Q9UJC3 AKTIP Homo sapiens Q9H8T0
Y2H Array
25416956
Intra HOOK1 Q9UJC3 AKTIP Homo sapiens Q9H8T0
Y2H
32073997
Intra HOOK1 Q9UJC3 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra HOOK1 Q9UJC3 USP2 Homo sapiens O75604
Y2H Prey Pooling
25416956
Intra HOOK1 Q9UJC3 BSG Homo sapiens P35613
Anti Bait CoIP
29423001
Intra HOOK1 Q9UJC3 BSG Homo sapiens P35613
Confocal
29423001
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure 16

SPGF16

Acephalic Spermatozoa Syndrome

Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome
Metanephric Adenoma
Renal Adenoma

Renal Cell Adenoma
Cranioectodermal Dysplasia 1

Sensenbrenner Syndrome

CED1

Levin Syndrome I

Cranio-Ectodermal Dysplasia

Dysplasia, Cranioectodermal, Type 1

Cranioectodermal Dysplasia
Ceroid Lipofuscinosis, Neuronal, 3

Batten Disease

Juvenile Neuronal Ceroid Lipofuscinosis

Neuronal Ceroid Lipofuscinosis 3

CLN3

Jncl

Spielmeyer-Vogt Disease

Vogt-Spielmeyer Disease

Spielmeyer-Sjogren Disease

Cln3 Disease

Neuronal Ceroid Lipofuscinosis, Juvenile

Cln3 Disease, Juvenile

Spielmeyer Sjogren Disease

Vogt Spielmeyer Disease

Batten-Mayou Disease

Batten-Spielmeyer-Vogt Disease

Cln3-Related Neuronal Ceroid-Lipofuscinosis

Juvenile Batten Disease

Juvenile Cerebroretinal Degeneration

Classic Juvenile Ncl

Classic Juvenile Neuronal Ceroid Lipofuscinosis

Juvenile Ncl

Lipofuscinosis, Ceroid, Neuronal, Type 3
Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-168619 DNA crosslinker 6 Inhibitor / 否
HY-RS06287 HOOK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HOOK1 MGD MGI:1925213
Rattus norvegicus HOOK1 RGD RGD:1309987
Canis familiaris HOOK1 VGNC VGNC:41740
Macaca mulatta HOOK1 VGNC VGNC:73424
Bos taurus HOOK1 VGNC VGNC:29905
Felis catus HOOK1 VGNC VGNC:62832
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