USP2 - ubiquitin specific peptidase 2 Gene

中文名称：泛素特异性肽酶 2

种属: Homo sapiens

同用名: USP9; UBP41

关于 USP2

功能概要

该基因编码去泛素化酶家族的一个成员，属于肽酶 C19 超家族。编码的蛋白质是一种泛素特异性蛋白酶，它是 TNF-α (肿瘤坏死因子 α) 诱导的 NF-kB (核因子 kB) 信号传导所必需的。这种蛋白质去泛素化多泛素化靶蛋白，如脂肪酸合酶、鼠双分钟 2 (MDM2) 、MDM4/MDMX 和细胞周期蛋白 D1。 MDM2 和 MDM4 是 p53 肿瘤抑制因子的负调节因子，细胞周期 G1/S 转换需要细胞周期蛋白 D1。已经鉴定出编码不同同种型的多个选择性剪接的转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the family of de-ubiquitinating Enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a Ubiquitin-Specific Protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]