GEMIN4 - gem nuclear organelle associated protein 4 Gene

中文名称：宝石核细胞器相关蛋白 4

种属: Homo sapiens

同用名: p97; HC56; HCAP1; HHRF-1; NEDMCR

关于 GEMIN4

功能概要

该基因的产物是定位于细胞质、核仁和称为双子体 (宝石) 的离散核体的大型复合体的一部分。该复合物在细胞质中的剪接体 snRNP 组装中发挥作用，并再生细胞核中 pre-mRNA 剪接所需的剪接体。编码的蛋白质直接与 DEAD 盒蛋白和几个剪接体核心蛋白相互作用。已经描述了选择性剪接的转录本变体，但尚未确定它们的生物学有效性。[RefSeq 提供，2008 年 7 月]

The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]