2. Gene
  3. UFC1 - ubiquitin-fold modifier conjugating enzyme 1 Gene

UFC1 - ubiquitin-fold modifier conjugating enzyme 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素折叠修饰结合酶 1

种属: Homo sapiens

同用名: NEDSG; HSPC155

基因 ID: 51506 | 基因类型: protein coding

关于 UFC1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,153,978-161,158,856 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and is associated with 2 phenotypes. Ubiquitous expression in urinary bladder (RPKM 37.2), ovary (RPKM 36.8) and 25 other tissues.

功能概要

UFC1 是泛素折叠修饰符 1 的 E2 样结合酶 (UFM1；MIM 610553) (Komatsu 等人，2004 年 [PubMed 15071506]) 。[OMIM 提供，2008 年 3 月]

UFC1 is an E2-like conjugating Enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]

UFC1 基因产物(1)

mRNA Protein Name
NM_016406.4 NP_057490.2 ubiquitin-fold modifier-conjugating enzyme 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables UFM1 conjugating enzyme activity IDA
IDA: 通过直接分析推断
15071506 GOA
enables UFM1 conjugating enzyme activity IMP
IMP: 通过突变表型推断
37036982 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20018847 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in brain development IMP
IMP: 通过突变表型推断
29868776 GOA
involved in protein K69-linked ufmylation IDA
IDA: 通过直接分析推断
25219498 GOA
involved in protein ufmylation IDA
IDA: 通过直接分析推断
15071506 GOA
acts upstream of or within protein ufmylation IMP
IMP: 通过突变表型推断
23152784 GOA
involved in protein ufmylation IMP
IMP: 通过突变表型推断
29868776 GOA
acts upstream of or within response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
23152784 GOA
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
32160526 GOA
involved in reticulophagy IMP
IMP: 通过突变表型推断
32160526 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UFC1 蛋白结构

UFC1

UFC1: Ubiquitin-fold modifier-conjugating enzyme 1 (5 - 164)

  • 0
  • 100
  • 167 a.a.
蛋白主名 其他名称

ubiquitin-fold modifier-conjugating enzyme 1

Ufm1-conjugating enzyme 1

UFC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra UFC1 Q9Y3C8 UFL1 Homo sapiens O94874
Pull Down
37595036
Intra UFC1 Q9Y3C8 UFL1 Homo sapiens O94874
Anti Tag CoIP
37595036
Intra UFC1 Q9Y3C8 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra UFC1 Q9Y3C8 GEMIN4 Homo sapiens P57678
Y2H Prey Pooling
32296183
Intra UFC1 Q9Y3C8 GEMIN4 Homo sapiens P57678
Y2H Array
32296183
Intra UFC1 Q9Y3C8 CDK5RAP3 Homo sapiens Q96JB5
Anti Tag CoIP
37595036
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Spasticity And Poor Growth

NEDSG
Osteoarthritis

Osteoarthrosis

Degenerative Joint Disease

Hypertrophic Arthritis

Arthropathy

Degenerative Polyarthritis

Degenerative Arthritis

Osteoarthrosis And Allied Disorder

Arthritis, Degenerative

Oa

Osteoarthritis Deformans

Osteoarthrosis Deformans

Kashin-Beck Disease
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24

Autosomal Recessive Spinocerebellar Ataxia 24

Spinocerebellar Ataxia, Autosomal Recessive, 24

Ataxia, Spinocerebellar, Autosomal Recessive, Type 24
Beukes Hip Dysplasia

Hip Dysplasia, Beukes Type

Beukes Familial Hip Dysplasia

BFHD

Cilliers-Beighton Syndrome

Osteoarthropathy, Premature Degenerative, Of Hip

Premature Degenerative Osteoarthropathy Of The Hip

BHD

Beukes Type Hip Dysplasia

Hip Dysplasia Beukes Type

Premature Degenerative Osteoarthropathy

Dysplasia, Hip, Beukes Type
Developmental And Epileptic Encephalopathy 44

DEE44

Epileptic Encephalopathy, Early Infantile, 44

Eiee44

Developmental And Epileptic Encephalopathy, 44

Early Infantile Epileptic Encephalopathy 44

Encephalopathy, Epileptic, Early Infantile, Type 44
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15413 UFC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus UFC1 MGD MGI:1913405
Canis familiaris UFC1 VGNC VGNC:48113
Rattus norvegicus UFC1 RGD RGD:1303313
Bos taurus UFC1 VGNC VGNC:36644
Felis catus UFC1 VGNC VGNC:103758
Macaca mulatta UFC1 VGNC VGNC:79643
Others UFC1 NCBI
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