UFL1 - UFM1 specific ligase 1 Gene

中文名称：UFM1 特异性连接酶 1

种属: Homo sapiens

同用名: NLBP; RCAD; Maxer; KIAA0776

基因 ID: 23376 | 基因类型: protein coding

关于 UFL1

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:96,521,806-96,555,276 (from NCBI)

This gene has 2 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in thyroid (RPKM 19.4), prostate (RPKM 15.2) and 25 other tissues.

功能概要

启用 UFM1 连接酶活性和蛋白激酶结合活性。参与多个过程，包括细胞蛋白质修饰过程；调节信号转导；和网状噬菌体。作用于多个过程的上游或内部，包括细胞群增殖的正向调节；蛋白酶体泛素依赖性蛋白质分解代谢过程的调节；和对内质网应激的反应。位于内质网膜；核;和双链断裂位点。部分含蛋白质复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables UFM1 Ligase activity and protein kinase binding activity. Involved in several processes, including cellular protein modification process; regulation of signal transduction; and reticulophagy. Acts upstream of or within several processes, including positive regulation of cell population proliferation; regulation of proteasomal ubiquitin-dependent protein catabolic process; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; nucleus; and site of double-strand break. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

UFL1 基因产物(1)

mRNA	Protein	Name
NM_015323.5	NP_056138.1	E3 UFM1-protein ligase 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables UFM1 ligase activity	IDA IDA: 通过直接分析推断	20018847	GOA
enables UFM1 ligase activity	IMP IMP: 通过突变表型推断	37036982	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20018847	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	30886146	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage checkpoint signaling	IDA IDA: 通过直接分析推断	30886146	GOA
involved in DNA damage response	IDA IDA: 通过直接分析推断	30783677	GOA
involved in negative regulation of IRE1-mediated unfolded protein response	IDA IDA: 通过直接分析推断	32160526	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	20164180	GOA
involved in negative regulation of T cell activation	IDA IDA: 通过直接分析推断	38377992	GOA
involved in negative regulation of T cell mediated immune response to tumor cell	IDA IDA: 通过直接分析推断	38377992	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	20164180	GOA
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	20531390	GOA
involved in positive regulation of proteolysis involved in protein catabolic process	IDA IDA: 通过直接分析推断	36543799	GOA
involved in positive regulation of reticulophagy	IDA IDA: 通过直接分析推断	36543799	GOA
involved in protein K69-linked ufmylation	IDA IDA: 通过直接分析推断	25219498	GOA
involved in protein stabilization	IDA IDA: 通过直接分析推断	32807901	GOA
involved in protein ufmylation	IDA IDA: 通过直接分析推断	20018847	GOA
acts upstream of or within protein ufmylation	IMP IMP: 通过突变表型推断	23152784	GOA
involved in protein ufmylation	IMP IMP: 通过突变表型推断	37036982	GOA
involved in regulation of intracellular estrogen receptor signaling pathway	IDA IDA: 通过直接分析推断	25219498	GOA
acts upstream of or within regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	20228063	GOA
acts upstream of or within regulation of protein localization	IMP IMP: 通过突变表型推断	20531390	GOA
involved in rescue of stalled ribosome	IDA IDA: 通过直接分析推断	37595036	GOA
involved in rescue of stalled ribosome	IMP IMP: 通过突变表型推断	37036982	GOA
acts upstream of or within response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	23152784	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	32160526	GOA
involved in reticulophagy	IDA IDA: 通过直接分析推断	32160526	GOA
involved in ribosome disassembly	IDA IDA: 通过直接分析推断	38383785	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	20164180	GOA
is active in endoplasmic reticulum	IDA IDA: 通过直接分析推断	37795761	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	20018847	GOA
is active in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	36543799	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	20531390	GOA
is active in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	20164180	GOA
located in nucleus	IDA IDA: 通过直接分析推断	30886146	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	20531390	GOA
located in site of double-strand break	IDA IDA: 通过直接分析推断	30886146	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UFL1 蛋白结构

E3_UFM1_ligase

0
200
400
600
794 a.a.

蛋白主名

其他名称

E3 UFM1-protein ligase 1

E3 UFM1-protein transferase 1

UFL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	UFL1	O94874	UFC1	Homo sapiens	Q9Y3C8	Anti Tag CoIP	33961781
Intra	UFL1	O94874	UFC1	Homo sapiens	Q9Y3C8	Anti Tag CoIP	37595036
Intra	UFL1	O94874	UFC1	Homo sapiens	Q9Y3C8	ITC	37595036
Intra	UFL1	O94874	DDRGK1	Homo sapiens	Q96HY6	Anti Tag CoIP	37595036
Intra	UFL1	O94874	CDK5RAP3	Homo sapiens	Q96JB5	Y2H Array	32296183
Intra	UFL1	O94874	CDK5RAP3	Homo sapiens	Q96JB5	Anti Tag CoIP	37595036
Intra	UFL1	O94874	CDK5RAP3	Homo sapiens	Q96JB5	Y2H Prey Pooling	32296183
Intra	UFL1	O94874	CDK5RAP3	Homo sapiens	Q96JB5	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Renal Cysts And Diabetes Syndrome

RCAD	Mody5
Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes	Cakut With Diabetes
Maturity-Onset Diabetes Of The Young Type 5	Tubulointerstitial Kidney Disease, Autosomal Dominant, 3
Adtkd3	Atypical Familial Juvenile Hyperuricemic Nephropathy
Atypical Fjhn	Familial Hypoplastic Glomerulocystic Kidney
Maturity-Onset Diabetes Of The Young, Type 5	Hyperuricemic Nephropathy, Familial Juvenile, Atypical
Fjhn, Atypical	Glomerulocystic Kidney Disease, Hypoplastic Type
Glomerulocystic Kidney, Familial Hypoplastic	Hypoplastic Type Glomerulocystic Kidney Disease
Glomerulocystic Kidney Disease Hypoplastic Type	Renal-Diabetes Mody5 Syndrome

Beukes Hip Dysplasia

Hip Dysplasia, Beukes Type	Beukes Familial Hip Dysplasia
BFHD	Cilliers-Beighton Syndrome
Osteoarthropathy, Premature Degenerative, Of Hip	Premature Degenerative Osteoarthropathy Of The Hip
BHD	Beukes Type Hip Dysplasia
Hip Dysplasia Beukes Type	Premature Degenerative Osteoarthropathy
Dysplasia, Hip, Beukes Type

Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24	Autosomal Recessive Spinocerebellar Ataxia 24
Spinocerebellar Ataxia, Autosomal Recessive, 24	Ataxia, Spinocerebellar, Autosomal Recessive, Type 24

Meier-Gorlin Syndrome 8

MGORS8

Deafness, Autosomal Dominant 70

DFNA70	Autosomal Dominant Nonsyndromic Deafness 70
Autosomal Dominant Deafness 70	Deafness, Autosomal Dominant, 70

Developmental And Epileptic Encephalopathy 44

DEE44	Epileptic Encephalopathy, Early Infantile, 44
Eiee44	Developmental And Epileptic Encephalopathy, 44
Early Infantile Epileptic Encephalopathy 44	Encephalopathy, Epileptic, Early Infantile, Type 44

Hairy Tongue

Overgrowth Of Filiform Papillae

Tongue, Hairy

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15415	UFL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	UFL1	MGD	MGI:1914740
Rattus norvegicus	UFL1	RGD	RGD:1309308
Bos taurus	UFL1	VGNC	VGNC:36646
Canis familiaris	UFL1	VGNC	VGNC:48115
Macaca mulatta	UFL1	VGNC	VGNC:79370
Felis catus	UFL1	VGNC	VGNC:66803

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UFL1 - UFM1 specific ligase 1 Gene

关于 UFL1

功能概要

UFL1 基因产物(1)

UFL1 蛋白结构

UFL1 蛋白互作信息

关联疾病

直系同源

热门区域

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UFL1 - UFM1 specific ligase 1 Gene

关于 UFL1

功能概要

UFL1 基因产物(1)

UFL1 蛋白结构

UFL1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z